Meis1
Gene Detail

Symbol Name ID

Meis1 Meis homeobox 1 MGI:104717

Synonyms

C530044H18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

11.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:18880430-19018958 bp, - strand From VEGA annotation of GRCm38   138529 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Meis1

Human homologs

Human Homolog		MEIS1, Meis homeobox 1
NCBI Gene ID		4211
neXtProt AC		NX_O00470
Human Chr (Location)		2p14; chr2:66662532-66799891 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(3)
 

Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	angiogenesis, blood vessel morphogenesis, ...
Component	nucleus, transcription factor complex
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (60 records)
Data Summary: Results (563)    Tissues (283)    Images (62)
Theiler Stages: 2, 3, 4, 5, 10, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	500
Northern blot	11
Western blot	1
RT-PCR	51

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(9) cDNA(30) Primer pair(3) Other(7)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005212 (Evidence)
Ensembl Gene Model	ENSMUSG00000020160 (Evidence)
Entrez Gene	17268 (Evidence)
DFCI	TC1581887, TC1583508, TC1595585, TC1621369, TC1623565
DoTS	DT.101274595, DT.101368555, DT.101725292, DT.40142709, DT.55124736, DT.87048994, DT.87068412, DT.91420178, DT.94338053
NIA Mouse Gene Index	U032546
Consensus CDS Project	CCDS24453.1, CCDS56760.1
International Mouse Knockout Project Status	Meis1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005212	VEGA Gene Model | MGI Sequence Detail	138529	C57BL/6J
transcript	OTTMUST00000011636	VEGA | MGI Sequence Detail	1890	Not Applicable
polypeptide	OTTMUSP00000005402	VEGA | MGI Sequence Detail	465	Not Applicable

All sequences(69) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(544 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000010316	homeobox protein Meis1

References

(Earliest) J:28792 Moskow JJ, et al., Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol. 1995 Oct;15(10):5434-43
(Latest) J:195126 Yang Z, et al., De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr;140(8):1774-84
All references(108)

Other accession IDs

MGD-MRK-27080, MGI:2443806