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Meis1
Gene Detail
 Symbol
Name
ID
Meis1
Meis homeobox 1
MGI:104717
Synonyms C530044H18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
11.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:18879817-19018985 bp, - strand
From VEGA annotation of GRCm38

  139169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86803  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Gene Tree: Meis1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production.
 
Interactions
Meis1 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component nucleus, transcription factor complex
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (556)    Tissues (288)    Images (61)
Theiler Stages: 2, 3, 4, 5, 10, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 500
Northern blot 11
Western blot 1
RT-PCR 44
cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(9) cDNA(30) Primer pair(3) Other(7)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005212 (Evidence)
Ensembl Gene ModelENSMUSG00000020160 (Evidence)
Entrez Gene17268 (Evidence)
DFCITC1581887, TC1583508, TC1595585, TC1621369, TC1623565
DoTSDT.101274595, DT.101368555, DT.101725292, DT.40142709, DT.55124736, DT.87048994, DT.87068412, DT.91420178, DT.94338053
NIA Mouse Gene IndexU032546
Consensus CDS ProjectCCDS24453.1, CCDS56760.1
International Mouse Knockout Project StatusMeis1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005212 VEGA Gene Model | MGI Sequence Detail 139169 C57BL/6J ±  kb
transcript OTTMUST00000011633 VEGA | MGI Sequence Detail 3196 Not Applicable 
polypeptide OTTMUSP00000005401 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(12) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(875 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010316 homeobox protein Meis1
References (Earliest) J:28792 Moskow JJ, et al., Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol. 1995 Oct;15(10):5434-43
(Latest) J:212177 Collins C, et al., C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9899-904
All references(117)
Other
accession IDs
MGD-MRK-27080, MGI:2443806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory