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Meis1
Gene Detail
Symbol

Name
ID
Meis1
Meis homeobox 1
MGI:104717
Synonyms
C530044H18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
11.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:18879817-19018985 bp, - strand
From VEGA annotation of GRCm38

  139169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86803  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Gene Tree: Meis1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production.
 
Interactions
Meis1 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component nucleus, transcription factor complex
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (555)    Tissues (286)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 499
Northern blot 11
Western blot 1
RT-PCR 44
cDNA source data(28)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase meis1 ; ZFIN meis1b    NEW 
Molecular
reagents
All nucleic(49) Genomic(9) cDNA(30) Primer pair(3) Other(7)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005212 (Evidence)
Ensembl Gene Model ENSMUSG00000020160 (Evidence)
Entrez Gene 17268 (Evidence)
DFCI TC1581887, TC1583508, TC1595585, TC1621369, TC1623565
DoTS DT.101274595, DT.101368555, DT.101725292, DT.40142709, DT.55124736, DT.87048994, DT.87068412, DT.91420178, DT.94338053
NIA Mouse Gene Index U032546
Consensus CDS Project CCDS24453.1, CCDS56760.1
International Mouse Phenotyping Consortium Status Meis1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005212 VEGA Gene Model | MGI Sequence Detail 139169 C57BL/6J ±  kb
transcript OTTMUST00000011633 VEGA | MGI Sequence Detail 3196 Not Applicable 
polypeptide OTTMUSP00000005401 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(9) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(875 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeobox domain
InterPro IPR008422 Homeobox KN domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010316 homeobox protein Meis1
References
(Earliest) J:28792 Moskow JJ, et al., Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol. 1995 Oct;15(10):5434-43
(Latest) J:222103 Roychoudhury J, et al., MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood. 2015 Apr 16;125(16):2544-52
All references(127)
Other
accession IDs
MGD-MRK-27080, MGI:2443806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory