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Muc5ac Gene Detail
Summary
  • Symbol
    Muc5ac
  • Name
    mucin 5, subtypes A and C, tracheobronchial/gastric
  • Synonyms
    2210005L13Rik, MGM
  • Feature Type
    protein coding gene
  • IDs
    MGI:104697
    NCBI Gene: 17833
  • Gene Overview
    MyGene.info: MUC5AC
Location & Maps
more
  • Sequence Map
    Chr7:141788972-141819231 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30260 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MUC5AC, mucin 5AC, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MUC5AC, mucin 5AC, oligomeric mucus/gel-forming
    Orthology source: HGNC, HomoloGene
  • Synonyms
    leB, MUC5, mucin, TBM
  • Links
    NCBI Gene ID: 4586
    neXtProt AC: NX_P98088

  • Chr Location
    11p15.5; chr11:1157953-1201138 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Muc5ac
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033677 VEGA Gene Model | MGI Sequence Detail 30260 C57BL/6J ±  kb
transcript OTTMUST00000084845 VEGA | MGI Sequence Detail 10752 Not Applicable  
polypeptide OTTMUSP00000045771 VEGA | MGI Sequence Detail 3455 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    225 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR002919 Trypsin Inhibitor-like, cysteine rich domain
    IPR014853 Uncharacterised domain, cysteine-rich
    IPR001846 von Willebrand factor, type D domain
    IPR001007 VWFC domain
    IPR025155 WxxW domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-27060, MGI:1920903
References
more
  • Summaries
    All 61
    Developmental Gene Expression 24
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:29531 Shekels LL, et al., Mouse gastric mucin: cloning and chromosomal localization. Biochem J. 1995 Nov 1;311(Pt 3):775-85
  • Latest
    J:230806 Arbi M, et al., GemC1 controls multiciliogenesis in the airway epithelium. EMBO Rep. 2016 Mar;17(3):400-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory