Muc5ac^tm1.1Evns
Targeted Allele Detail

Summary

• Symbol: Muc5ac^tm1.1Evns
• Name: mucin 5, subtypes A and C, tracheobronchial/gastric; targeted mutation 1.1, Christopher M Evans
• MGI ID: MGI:5295259
• Synonyms: Muc5ac^delta, Muc5ac^tm1.1Tigm
• Gene: Muc5ac Location: Chr7:141342709-141372968 bp, + strand Genetic Position: Chr7, 87.23 cM
• Alliance: Muc5ac^tm1.1Evns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177306
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the floxed exon 1. The absence of protein expression was confirmed by immunofluorescence on cecum samples. (J:177306)

Generation of the Muc5ac^tm1.1Evns allele

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc5ac Mutation: 169 strains or lines available

References

• Original: J:177306 Hasnain SZ, et al., Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 9;208(5):893-900
• All: 13 reference(s)