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Scnn1g
Gene Detail
Symbol

Name
ID
Scnn1g
sodium channel, nonvoltage-gated 1 gamma
MGI:104695
Synonyms
ENaC gamma
Feature Type
protein coding gene
Genetic Map
Chromosome 7
65.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:121734479-121768475 bp, + strand
From VEGA annotation of GRCm38

  33997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Scnn1g

Human
homologs
Human Homolog SCNN1G, sodium channel, non-voltage-gated 1, gamma subunit
NCBI Gene ID 6340
neXtProt AC  NX_P51170
Human Synonyms  BESC3, ENaCg, ENaCgamma, PHA1, SCNEG
Human Chr (Location)  16p12; chr16:23182719-23216880 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human SCNN1G
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in partial lethality between 24-36 hours after birth. Newborns exhibit hyperkalemia, clear lung liquid more slowly, and show low urinary potassium and high urinary sodium concentrations.
 
Human Diseases Modeled Using Mouse Scnn1g (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Scnn1g interacts with 237 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process ion transport, multicellular organismal water homeostasis, ...
Component apical plasma membrane, cell surface, ...
Function ligand-gated sodium channel activity, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (135)    Tissues (70)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 101
RT-PCR 4
RNase protection 30
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024632 (Evidence)
Ensembl Gene ModelENSMUSG00000000216 (Evidence)
Entrez Gene20278 (Evidence)
UniGene35247
DFCITC1585356
DoTSDT.40140053
Consensus CDS ProjectCCDS21803.1
International Mouse Knockout Project StatusScnn1g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024632 VEGA Gene Model | MGI Sequence Detail 33997 C57BL/6J ±  kb
transcript OTTMUST00000060557 VEGA | MGI Sequence Detail 2991 Not Applicable 
polypeptide OTTMUSP00000029537 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004724 Epithelial sodium channel
InterPro IPR001873 Na+ channel, amiloride-sensitive
InterPro IPR020903 Na+ channel, amiloride-sensitive, conserved site
Protein Ontology PR:000014530 amiloride-sensitive sodium channel subunit gamma
References
(Earliest) J:29372 Brooker DR, et al., Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7. Genomics. 1995 Oct 10;29(3):784-6
(Latest) J:202944 Shi S, et al., Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block. Am J Physiol Renal Physiol. 2013 Dec;305(11):F1585-92
All references(68)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-27058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory