Scnn1g
Gene Detail

Symbol Name ID

Scnn1g sodium channel, nonvoltage-gated 1 gamma MGI:104695

Synonyms

ENaC gamma

Feature Type

protein coding gene

Genetic Map

Chromosome 7

65.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:121734479-121768475 bp, + strand From VEGA annotation of GRCm38   33997 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Scnn1g

Human homologs

Human Homolog		SCNN1G, sodium channel, non-voltage-gated 1, gamma subunit
NCBI Gene ID		6340
neXtProt AC		NX_P51170
Human Synonyms		BESC3, ENaCg, ENaCgamma, PHA1, SCNEG
Human Chr (Location)		16p12; chr16:23194040-23228200 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human SCNN1G

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous mutation of this gene results in partial lethality between 24-36 hours after birth. Newborns exhibit hyperkalemia, clear lung liquid more slowly, and show low urinary potassium and high urinary sodium concentrations.

 
Human Diseases Modeled Using Mouse Scnn1g (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	ion transport, response to stimulus, ...
Component	apical plasma membrane, cell surface, ...
Function	ion channel activity, ligand-gated sodium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (78)    Tissues (14)    Images (23)
Theiler Stages: 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	44
RT-PCR	4
RNase protection	30

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024632 (Evidence)
Ensembl Gene Model	ENSMUSG00000000216 (Evidence)
Entrez Gene	20278 (Evidence)
UniGene	35247
DFCI	TC1585356
DoTS	DT.40140053
Consensus CDS Project	CCDS21803.1
International Mouse Knockout Project Status	Scnn1g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024632	VEGA Gene Model | MGI Sequence Detail	33997	C57BL/6J
transcript	OTTMUST00000060557	VEGA | MGI Sequence Detail	2991	Not Applicable
polypeptide	OTTMUSP00000029537	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004724	Epithelial sodium channel
InterPro	IPR001873	Na+ channel, amiloride-sensitive
InterPro	IPR020903	Na+ channel, amiloride-sensitive, conserved site
Protein Ontology	PR:000014530	amiloride-sensitive sodium channel subunit gamma

References

(Earliest) J:29372 Brooker DR, et al., Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7. Genomics. 1995 Oct 10;29(3):784-6
(Latest) J:190056 Xu Y, et al., Transcriptional programs controlling perinatal lung maturation. PLoS One. 2012;7(8):e37046
All references(62)

Other accession IDs

MGD-MRK-27058