Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium channel activity. Involved in intracellular sodium ion homeostasis and sodium ion import across plasma membrane. Acts upstream of or within cellular response to aldosterone and sodium ion transmembrane transport. Located in external side of plasma membrane. Part of sodium channel complex. Is expressed in several structures, including bladder fundus; lung; metanephros; pharyngo-tympanic tube; and ureter. Used to study autosomal recessive pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (sodium channel epithelial 1 subunit gamma).