Col4a4
Gene Detail

Symbol Name ID

Col4a4 collagen, type IV, alpha 4 MGI:104687

Synonyms

[a]4(IV), E130010M05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

42.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:82452558-82586849 bp, - strand From VEGA annotation of GRCm38   134292 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20071  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Col4a4

Human homologs

Human Homolog		COL4A4, collagen, type IV, alpha 4
NCBI Gene ID		1286
neXtProt AC		NX_P53420
Human Synonyms		CA44
Human Chr (Location)		2q35-q37; chr2:227867427-228029275 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human COL4A4

Alleles and phenotypes

All alleles(1) : Chemically induced(1)
Human Diseases Modeled Using Mouse Col4a4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	glomerular basement membrane development
Component	basal lamina, basement membrane, ...
Function	extracellular matrix structural constituent

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (9)    Tissues (6)    Images (2)
Theiler Stages: 15, 17, 24, 26

Assay Type	Results
Immunohistochemistry	5
RT-PCR	4

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021695 (Evidence)
Ensembl Gene Model	ENSMUSG00000067158 (Evidence)
Entrez Gene	12829 (Evidence)
DFCI	TC1588605, TC1612505, TC1632485
DoTS	DT.55136103
NIA Mouse Gene Index	U021531
Consensus CDS Project	CCDS35630.1
International Mouse Knockout Project Status	Col4a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021695	VEGA Gene Model | MGI Sequence Detail	134292	C57BL/6J
transcript	OTTMUST00000051472	VEGA | MGI Sequence Detail	5973	Not Applicable
polypeptide	OTTMUSP00000024234	VEGA | MGI Sequence Detail	1682	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(700 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001442	Collagen IV, non-collagenous
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR016187	C-type lectin fold
Protein Ontology	PR:000003337	collagen alpha-4(IV) chain

References

(Earliest) J:21122 Miner JH, et al., Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches. J Cell Biol. 1994 Nov;127(3):879-91
(Latest) J:187697 Sasaki M, et al., D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012 Sep 15;26(18):2038-49
All references(46)

Other accession IDs

MGD-MRK-27050, MGI:2442835