Gene Expression Literature Summary

• Symbol: Col4a4
• Name: collagen, type IV, alpha 4
• ID: MGI:104687

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)				1	2	2	1	1	2	2	1	3	1	1	3	1	9
In situ RNA (section)																1
Northern blot																	1
Western blot							1
RT-PCR	1	1	1						1		1	2			2		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col4a4  collagen, type IV, alpha 4   (Synonyms: [a]4(IV), E130010M05Rik)
Results	Reference
1	J:63137 Andrews KL, Betsuyaku T, Rogers S, Shipley JM, Senior RM, Miner JH, Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of alport syndrome. Am J Pathol. 2000 Jul;157(1):303-11
1	J:324218 Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Muller-Deile J, Schluter H, Puelles VG, Bergmann C, Huber TB, Grahammer F, Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy. J Clin Invest. 2022 May 2;132(9):e147253
5	J:150527 Bai X, Dilworth DJ, Weng YC, Gould DB, Developmental distribution of collagen IV isoforms and relevance to ocular diseases. Matrix Biol. 2009 May;28(4):194-201
1	J:306061 Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H, High proliferation and delamination during skin epidermal stratification. Nat Commun. 2021 May 28;12(1):3227
1	J:70294 Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM, Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med. 2001 Jul 2;194(1):13-27
1*	J:30369 Enders GC, Kahsai TZ, Lian G, Funabiki K, Killen PD, Hudson BG, Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis. Biol Reprod. 1995 Dec;53(6):1489-99
2	J:237202 Fantauzzo KA, Soriano P, PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev. 2016 Nov 01;30(21):2443-2458
1	J:158314 Firtina Z, Danysh BP, Bai X, Gould DB, Kobayashi T, Duncan MK, Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J Biol Chem. 2009 Dec 18;284(51):35872-84
1	J:130822 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R, Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15;313(2):584-93
1	J:82909 Kikkawa Y, Virtanen I, Miner JH, Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol. 2003 Apr 14;161(1):187-96
1	J:263002 Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Kimura-Ono A, Takarada T, Momota R, Maekawa K, Kuboki T, Oohashi T, Type IV collagen alpha6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Sci Rep. 2018 Feb 8;8(1):2612
1	J:335095 Lipp SN, Jacobson KR, Schwaderer AL, Hains DS, Calve S, FOXD1 is required for 3D patterning of the kidney interstitial matrix. Dev Dyn. 2023 Apr;252(4):463-482
1*	J:139122 Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K, Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12849-54
1	J:40354 Marin M, Karis A, Visser P, Grosveld F, Philipsen S, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
4	J:74207 Nagai N, Nakano K, Sado Y, Naito I, Gunduz M, Tsujigiwa H, Nagatsuka H, Ninomiya Y, Siar CH, Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development. Int J Dev Biol. 2001 Oct;45(7):827-31
1	J:288722 Nilsson D, Heglind M, Arani Z, Enerback S, Foxc2 is essential for podocyte function. Physiol Rep. 2019 May;7(9):e14083
2*	J:89190 Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U, Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004 Apr;131(7):1619-28
6	J:42107 Qin P, Piechocki M, Lu S, Kurpakus MA, Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye. Dev Dyn. 1997 Aug;209(4):367-76
1	J:298990 Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N, Bohio AA, Nagi FH, Feng X, Zhang L, Zheng Y, Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
2	J:163649 Sani FV, Kaartinen V, El Shahawy M, Linde A, Gritli-Linde A, Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Eur J Oral Sci. 2010 Jun;118(3):221-36
2	J:187697 Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW, D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012 Sep 15;26(18):2038-49
1	J:92208 Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M, Nishinakamura R, Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 2004 Jun;121(6):547-57
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
4	J:235682 Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE, Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70