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Hgs Gene Detail
Summary
  • Symbol
    Hgs
  • Name
    HGF-regulated tyrosine kinase substrate
  • Synonyms
    Hrs, tn
  • Feature Type
    protein coding gene
  • IDs
    MGI:104681
    NCBI Gene: 15239
  • Gene Overview
    MyGene.info: HGS
Location & Maps
more
  • Sequence Map
    Chr11:120467635-120483979 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16345 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRS
  • Links
    NCBI Gene ID: 9146
    neXtProt AC: NX_O14964

  • Chr Location
    17q25; chr17:81683932-81702121 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    4
  • Spontaneous
    1
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis with decreased size and no embryo turning. In addition, one allele shows cardia bifida, no foregut formation, failure of chorioallantoic fusion and neural tube,somite and allantois defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004240 VEGA Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
transcript OTTMUST00000009586 VEGA | MGI Sequence Detail 2901 Not Applicable  
polypeptide OTTMUSP00000004647 VEGA | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008536 hepatocyte growth factor-regulated tyrosine kinase substrate
  • InterPro Domains
    IPR008942 ENTH/VHS
    IPR000306 FYVE zinc finger
    IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
    IPR017073 Ubiquitin binding protein, Hrs/VPS27
    IPR003903 Ubiquitin interacting motif
    IPR002014 VHS domain
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR017455 Zinc finger, FYVE-related
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 125
    cDNA 125

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15148, MGD-MRK-27044, MGI:98778
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:13411 Lane PW, et al., Teetering (tn). Mouse News Lett. 1962;27:38
  • Latest
    J:221937 Watson JA, et al., Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory