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Hgs
Gene Detail
Symbol

Name
ID
Hgs
HGF-regulated tyrosine kinase substrate
MGI:104681
Synonyms
Hrs, tn
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:120467635-120483979 bp, + strand
From VEGA annotation of GRCm38

  16345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HGS
Protein SuperFamily: ubiquitin binding protein, Hrs/Vps27 type
Gene Tree: Hgs

Human
homologs
HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9146
neXtProt AC: NX_O14964

Human Synonyms: HRS

Human Chr (Location): 17q25; chr17:81683932-81702121 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Spontaneous(1) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis with decreased size and no embryo turning. In addition, one allele shows cardia bifida, no foregut formation, failure of chorioallantoic fusion and neural tube, somite and allantois defects.
 
Interactions
Hgs interacts with 103 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process endosome to lysosome transport, intracellular protein transport, ...
Component cytoplasm, cytosol, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (82)    Tissues (31)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
Northern blot 12
cDNA source data(124)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hgs ; ZFIN hgs    NEW 
Molecular
reagents
All nucleic(125) cDNA(125)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004240 (Evidence)
Ensembl Gene Model ENSMUSG00000025793 (Evidence)
Entrez Gene 15239 (Evidence)
UniGene 7919
DFCI TC1572093
DoTS DT.101407302, DT.492972, DT.94354997, DT.99862064
NIA Mouse Gene Index U013662
Consensus CDS Project CCDS49005.1
International Mouse Phenotyping Consortium Status Hgs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004240 VEGA Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
transcript OTTMUST00000009586 VEGA | MGI Sequence Detail 2901 Not Applicable 
polypeptide OTTMUSP00000004647 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008942 ENTH/VHS
InterPro IPR000306 FYVE zinc finger
InterPro IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
InterPro IPR017073 Ubiquitin binding protein, Hrs/VPS27
InterPro IPR003903 Ubiquitin interacting motif
InterPro IPR002014 VHS domain
InterPro IPR018205 VHS subgroup
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000008536 hepatocyte growth factor-regulated tyrosine kinase substrate
References
(Earliest) J:13411 Lane PW, et al., Teetering (tn). Mouse News Lett. 1962;27:38
(Latest) J:221937 Watson JA, et al., Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290
All references(54)
Other
accession IDs
MGD-MRK-15148, MGD-MRK-27044, MGI:98778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory