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Hgs
Gene Detail
Symbol

Name
ID
Hgs
HGF-regulated tyrosine kinase substrate
MGI:104681
Synonyms
Hrs
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:120467635-120483979 bp, + strand
From VEGA annotation of GRCm38

  16345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ubiquitin binding protein, Hrs/Vps27 type
Gene Tree: Hgs

Human
homologs
Human Homolog HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
NCBI Gene ID 9146
neXtProt AC  NX_O14964
Human Synonyms  HRS
Human Chr (Location)  17q25; chr17:81683932-81702121 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(4) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis with decreased size and no embryo turning. In addition, one allele shows cardia bifida, no foregut formation, failure of chorioallantoic fusion and neural tube, somite and allantois defects.
 
Interactions
Hgs interacts with 103 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process endosome to lysosome transport, intracellular protein transport, ...
Component cytoplasm, cytosol, ...
Function metal ion binding, protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (82)    Tissues (31)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
Northern blot 12
cDNA source data(124)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) cDNA(125)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004240 (Evidence)
Ensembl Gene ModelENSMUSG00000025793 (Evidence)
Entrez Gene15239 (Evidence)
UniGene7919
DFCITC1572093
DoTSDT.101407302, DT.492972, DT.94354997, DT.99862064
NIA Mouse Gene IndexU013662
Consensus CDS ProjectCCDS49005.1
International Mouse Knockout Project StatusHgs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004240 VEGA Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
transcript OTTMUST00000009586 VEGA | MGI Sequence Detail 2901 Not Applicable 
polypeptide OTTMUSP00000004647 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008942 ENTH/VHS
InterPro IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
InterPro IPR017073 Ubiquitin binding protein, Hrs/VPS27
InterPro IPR003903 Ubiquitin interacting motif
InterPro IPR002014 VHS
InterPro IPR018205 VHS subgroup
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000008536 hepatocyte growth factor-regulated tyrosine kinase substrate
References
(Earliest) J:29402 Komada M, et al., Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol. 1995 Nov;15(11):6213-21
(Latest) J:211491 Nagata T, et al., Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells. Biochem Biophys Res Commun. 2014 Jan 10;443(2):351-6
All references(48)
Other
accession IDs
MGD-MRK-27044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory