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Tfap2a
Gene Detail
Symbol

Name
ID
Tfap2a
transcription factor AP-2, alpha
MGI:104671
Synonyms
Ap2, Ap-2 (a), AP2alpha, AP-2 alpha, Ap2tf, Tcfap2a
Feature Type
protein coding gene
Genetic Map
Chromosome 13
20.01 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:40715675-40733823 bp, - strand
From Ensembl annotation of GRCm38

  18149 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFAP2A
Gene Tree: Tfap2a

Human
homologs
TFAP2A, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7020
neXtProt AC: NX_P05549

Human Synonyms: AP-2, AP-2alpha, AP2TF, BOFS, TFAP2

Human Chr (Location): 6p24; chr6:10396677-10419624 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TFAP2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die perinatally with anencephaly, craniofacial and neural tube defects, thoraco-abdominoschisis and defects in sensory organs, cranial ganglia, skeleton, and heart. On some genetic backgrounds, heterozygotes may exhibit exencephaly.
 
Phenotype Images(2)
Interactions
Tfap2a interacts with 257 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (184 records)
Data Summary: Results (619)    Tissues (316)    Images (105)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 435
In situ reporter (knock in) 2
Northern blot 1
Western blot 2
RT-PCR 103
RNase protection 54
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TFAP2A ; Xenbase tfap2a ; ZFIN tfap2a    NEW 
Molecular
reagents
All nucleic(76) Genomic(3) cDNA(46) Primer pair(26) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021359 (Evidence)
Entrez Gene 21418 (Evidence)
DFCI TC1582950, TC1729177, TC1672015, TC1588477, TC1633802, TC1599545
DoTS DT.91338934, DT.523585, DT.101266492, DT.101210954, DT.99805203
NIA Mouse Gene Index U034706
Consensus CDS Project CCDS26467.1, CCDS49243.1
International Mouse Phenotyping Consortium Status Tfap2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021359 Ensembl Gene Model | MGI Sequence Detail 18149 C57BL/6J ±  kb
transcript ENSMUST00000110193 Ensembl | MGI Sequence Detail 2863 Not Applicable 
polypeptide ENSMUSP00000105822 Ensembl | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004979 Transcription factor AP-2
InterPro IPR008121 Transcription factor AP-2 alpha, N-terminal
InterPro IPR013854 Transcription factor AP-2, C-terminal
Protein Ontology PR:000016263 transcription factor AP-2-alpha
References
(Earliest) J:15697 Mitchell PJ, et al., Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 1991 Jan;5(1):105-19
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(255)
Other
accession IDs
MGD-MRK-1346, MGD-MRK-27034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory