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Tfap2a
Gene Detail
 Symbol
Name
ID
Tfap2a
transcription factor AP-2, alpha
MGI:104671
Synonyms Ap2, Ap-2 (a), AP2alpha, AP-2 alpha, Ap2tf, Tcfap2a
Feature Type protein coding gene
Genetic Map
Chromosome 13
20.01 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:40715675-40733823 bp, - strand
From NCBI annotation of GRCm38

  18149 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tfap2a

Human
homologs
Human Homolog TFAP2A, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
NCBI Gene ID 7020
neXtProt AC  NX_P05549
Human Synonyms  AP-2, AP-2alpha, AP2TF, BOFS, TFAP2
Human Chr (Location)  6p24; chr6:10396677-10419564 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TFAP2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die perinatally with anencephaly, craniofacial and neural tube defects, thoraco-abdominoschisis and defects in sensory organs, cranial ganglia, skeleton, and heart. On some genetic backgrounds, heterozygotes may exhibit exencephaly.
 
Phenotype Images(2)
Interactions
Tfap2a interacts with 257 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (99 annotations)
Process anterior neuropore closure, basement membrane organization, ...
Component centrosome, cytoplasm, ...
Function chromatin binding, core promoter proximal region sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (169 records)
Data Summary: Results (603)    Tissues (307)    Images (93)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 415
In situ reporter (knock in) 2
Northern blot 1
Western blot 2
RT-PCR 114
RNase protection 54
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(3) cDNA(66) Primer pair(26) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021359 (Evidence)
Entrez Gene21418 (Evidence)
UniGene85544
DFCITC1582950, TC1588477, TC1599545, TC1633802, TC1672015
DoTSDT.101210954, DT.101266492, DT.523585, DT.91338934, DT.99805203
NIA Mouse Gene IndexU034706
Consensus CDS ProjectCCDS26467.1, CCDS49243.1
International Mouse Knockout Project StatusTfap2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21418 NCBI Gene Model | MGI Sequence Detail 18149 C57BL/6J ±  kb
transcript NM_001122948 RefSeq | MGI Sequence Detail 3114 C57BL/6 
polypeptide P34056 UniProt | EBI | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(14) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004979 Transcription factor AP-2
InterPro IPR008121 Transcription factor AP-2 alpha, N-terminal
InterPro IPR013854 Transcription factor AP-2, C-terminal
Protein Ontology PR:000016263 transcription factor AP-2-alpha
Graphical View of Protein Domain Structure
References (Earliest) J:15697 Mitchell PJ, et al., Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 1991 Jan;5(1):105-19
(Latest) J:206963 Orieux G, et al., Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. J Neurosci. 2014 Jan 22;34(4):1530-41
All references(239)
Other
accession IDs
MGD-MRK-1346, MGD-MRK-27034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory