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Fkbp5 Gene Detail
Summary
  • Symbol
    Fkbp5
  • Name
    FK506 binding protein 5
  • Synonyms
    D17Ertd592e, Dit1, FKBP51
  • Feature Type
    protein coding gene
  • IDs
    MGI:104670
    NCBI Gene: 14229
  • Gene Overview
    MyGene.info: FKBP5
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28398753-28486149 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.66 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104670
protein coding gene Chr17:28398753-28517524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023441
protein coding gene Chr17:27796305-27927738 (-)
A/J MGP_AJ_G0023399
protein coding gene Chr17:26880955-27001129 (-)
AKR/J MGP_AKRJ_G0023364
protein coding gene Chr17:27083062-27209478 (-)
BALB/cJ MGP_BALBcJ_G0023404
protein coding gene Chr17:27150808-27272573 (-)
C3H/HeJ MGP_C3HHeJ_G0023165
protein coding gene Chr17:27470456-27595237 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023846
protein coding gene Chr17:28931289-29060741 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021321
protein coding gene Chr17:24253585-24368990 (-)
CAST/EiJ MGP_CASTEiJ_G0022666
protein coding gene Chr17:27446549-27574719 (-)
CBA/J MGP_CBAJ_G0023139
protein coding gene Chr17:29964668-30102895 (-)
DBA/2J MGP_DBA2J_G0023270
protein coding gene Chr17:26436076-26559396 (-)
FVB/NJ MGP_FVBNJ_G0023240
protein coding gene Chr17:26250540-26372809 (-)
LP/J MGP_LPJ_G0023348
protein coding gene Chr17:28061084-28190187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023258
protein coding gene Chr17:29379712-29520037 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023888
protein coding gene Chr17:27520725-27647664 (-)
PWK/PhJ MGP_PWKPhJ_G0022416
protein coding gene Chr17:25252360-25378040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022234
protein coding gene Chr17:25505281-25628530 (-)
WSB/EiJ MGP_WSBEiJ_G0022728
protein coding gene Chr17:27507735-27635883 (-)



Homology
more
  • Human Ortholog
    FKBP5, FK506 binding protein 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FKBP5, FK506 binding protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10
  • Links
    NCBI Gene ID: 2289
    neXtProt AC: NX_Q13451
    UniProt: Q13451

  • Chr Location
    6p21.31; chr6:35573585-35728583 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FKBP5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are normal and fertile. Mice homozygous for another knock-out allele exhibit decreased depression-related behavior and increased anxiety-related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14229 NCBI Gene Model | MGI Sequence Detail 87397 C57BL/6J ±  kb
    transcript NM_010220 RefSeq | MGI Sequence Detail 3884 C57BL/6  
    polypeptide Q64378 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007541 peptidyl-prolyl cis-trans isomerase FKBP5
    • EC
    • InterPro Domains
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR031210 Peptidyl-prolyl cis-trans isomerase FKBP5
      IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001440 Tetratricopeptide repeat 1
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 174
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16741, MGD-MRK-27033, MGI:1261871
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:11336 Baughman G, et al., Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol Endocrinol. 1991 May;5(5):637-44
    • Latest
      J:257192 Balsevich G, et al., Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 2017 Nov 23;8(1):1725

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory