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Fkbp5
Gene Detail
Symbol

Name
ID
Fkbp5
FK506 binding protein 5
MGI:104670
Synonyms
D17Ertd592e, Dit1, FKBP51
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:28399095-28517524 bp, - strand
From VEGA annotation of GRCm38

  118430 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: FKBP5
Protein SuperFamily: FK506-binding protein 5
Gene Tree: Fkbp5

Human
homologs
FKBP5, FK506 binding protein 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2289
neXtProt AC: NX_Q13451

Human Synonyms: AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10

Human Chr (Location): 6p21.31; chr6:35573585-35728583 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FKBP5

Mutations,
alleles, and
phenotypes
All mutations/alleles(273) : Gene trapped(269) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele are normal and fertile. Mice homozygous for another knock-out allele exhibit decreased depression-related behavior and increased anxiety-related behavior.
 
Interactions
Fkbp5 interacts with 231 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chaperone-mediated protein folding, protein folding, ...
Component cytoplasm, endoplasmic reticulum membrane, ...
Function FK506 binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (51)    Tissues (46)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 46
cDNA source data(171)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(174) cDNA(172) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000024255 (Evidence)
Ensembl Gene Model ENSMUSG00000024222 (Evidence)
Entrez Gene 14229 (Evidence)
UniGene 276405
DFCI TC1572635, TC1763872
DoTS DT.101707276, DT.103563601, DT.110561872, DT.110561902, DT.111074754, DT.535658
NIA Mouse Gene Index U037607
EC 5.2.1.8
Consensus CDS Project CCDS37528.1
International Mouse Phenotyping Consortium Status Fkbp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024255 VEGA Gene Model | MGI Sequence Detail 118430 C57BL/6J ±  kb
transcript OTTMUST00000059380 VEGA | MGI Sequence Detail 3542 Not Applicable 
polypeptide OTTMUSP00000028876 VEGA | MGI Sequence Detail 456 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023114 Elongated TPR repeat-containing domain
InterPro IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR011990 Tetratricopeptide-like helical domain
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR001440 Tetratricopeptide repeat 1
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000007541 peptidyl-prolyl cis-trans isomerase FKBP5
References
(Earliest) J:11336 Baughman G, et al., Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol Endocrinol. 1991 May;5(5):637-44
(Latest) J:223422 Sabbagh JJ, et al., Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. PLoS One. 2014;9(9):e107241
All references(63)
Other
accession IDs
MGD-MRK-16741, MGD-MRK-27033, MGI:1261871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory