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Fkbp5 Gene Detail
Summary
  • Symbol
    Fkbp5
  • Name
    FK506 binding protein 5
  • Synonyms
    D17Ertd592e, Dit1, FKBP51
  • Feature Type
    protein coding gene
  • IDs
    MGI:104670
    NCBI Gene: 14229
  • Gene Overview
    MyGene.info: FKBP5
Location & Maps
more
  • Sequence Map
    Chr17:28399095-28517524 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118430 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.66 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FKBP5, FK506 binding protein 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FKBP5, FK506 binding protein 5
    Orthology source: HomoloGene
  • Synonyms
    AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10
  • Links
    NCBI Gene ID: 2289
    neXtProt AC: NX_Q13451

  • Chr Location
    6p21.31; chr6:35573585-35728583 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FKBP5 associations

Human Disease Mouse Models
       Major Depressive Disorder; MDD   OMIM: 608516
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are normal and fertile. Mice homozygous for another knock-out allele exhibit decreased depression-related behavior and increased anxiety-related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024255 VEGA Gene Model | MGI Sequence Detail 118430 C57BL/6J ±  kb
transcript OTTMUST00000059383 VEGA | MGI Sequence Detail 3858 Not Applicable  
polypeptide OTTMUSP00000028878 VEGA | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    411 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007541 peptidyl-prolyl cis-trans isomerase FKBP5
  • EC
  • InterPro Domains
    IPR023114 Elongated TPR repeat-containing domain
    IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
    IPR031210 Peptidyl-prolyl cis-trans isomerase FKBP5
    IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 176
    cDNA 173
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-16741, MGD-MRK-27033, MGI:1261871
References
more
  • Summaries
    All 66
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:11336 Baughman G, et al., Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol Endocrinol. 1991 May;5(5):637-44
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory