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Pml
Gene Detail
Symbol

Name
ID
Pml
promyelocytic leukemia
MGI:104662
Synonyms
1200009E24Rik, Trim19
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:58218076-58249786 bp, - strand
From VEGA annotation of GRCm38

  31711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: PML
Gene Tree: Pml

Human
homologs
PML, promyelocytic leukemia
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5371
neXtProt AC: NX_P29590

Human Synonyms: MYL, PP8675, RNF71, TRIM19

Human Chr (Location): 15q22; chr15:73994673-74047819 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(95) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Pml interacts with 265 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (112 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function cobalt ion binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (146)    Tissues (114)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 79
Northern blot 12
RT-PCR 54
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(4) cDNA(24) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000033332 (Evidence)
Ensembl Gene Model ENSMUSG00000036986 (Evidence)
Entrez Gene 18854 (Evidence)
DFCI TC1572045, TC1587921, TC1610756, TC1628785, TC1634388
DoTS DT.101343246, DT.101404898, DT.101404905, DT.110598933, DT.531781, DT.55218027, DT.55230140, DT.91291330, DT.94225846, DT.99853345
NIA Mouse Gene Index U030936, U371821
Consensus CDS Project CCDS23239.1, CCDS23240.2
International Mouse Phenotyping Consortium Status Pml
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033332 VEGA Gene Model | MGI Sequence Detail 31711 C57BL/6J ±  kb
transcript OTTMUST00000083649 VEGA | MGI Sequence Detail 4481 Not Applicable 
polypeptide OTTMUSP00000044973 VEGA | MGI Sequence Detail 885 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(14) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)    SNPs within 2kb including multiple locations(120)
Protein-related
information
ResourceIDDescription
InterPro IPR021978 Protein of unknown function DUF3583
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000026474 transcription factor PML
References
(Earliest) J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
(Latest) J:219619 Dowling JK, et al., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J Biol Chem. 2014 Mar 7;289(10):6429-37
All references(119)
Other
accession IDs
MGD-MRK-26102, MGI:2143109, MGI:2443400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory