Pml
Gene Detail

Symbol Name ID

Pml promyelocytic leukemia MGI:104662

Synonyms

1200009E24Rik, Trim19

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:58218076-58249786 bp, - strand From VEGA annotation of GRCm38   31711 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 chicken

Gene Tree: Pml

Human homologs

Human Homolog		PML, promyelocytic leukemia
NCBI Gene ID		5371
neXtProt AC		NX_P29590
Human Synonyms		MYL, PP8675, RNF71, TRIM19
Human Chr (Location)		15q22; chr15:74287014-74340160 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(99) : Targeted(4) Gene trapped(95)
 

Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors.

 

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	cobalt ion binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (153)    Tissues (112)    Images (10)
Theiler Stages: 1, 2, 3, 4, 5, 10, 15, 17, 18, 19, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	79
Northern blot	12
RT-PCR	61

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(4) cDNA(23) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000033332 (Evidence)
Ensembl Gene Model	ENSMUSG00000036986 (Evidence)
Entrez Gene	18854 (Evidence)
DFCI	TC1572045, TC1587921, TC1610756, TC1628785, TC1634388
DoTS	DT.101343246, DT.101404898, DT.101404905, DT.110598933, DT.531781, DT.55218027, DT.55230140, DT.91291330, DT.94225846, DT.99853345
NIA Mouse Gene Index	U030936, U371821
Consensus CDS Project	CCDS23239.1, CCDS23240.2
International Mouse Knockout Project Status	Pml

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033332	VEGA Gene Model | MGI Sequence Detail	31711	C57BL/6J
transcript	OTTMUST00000083649	VEGA | MGI Sequence Detail	4481	Not Applicable
polypeptide	OTTMUSP00000044973	VEGA | MGI Sequence Detail	885	Not Applicable

All sequences(101) RefSeq(4) UniProt(10)

Polymorphisms

RFLP(1) : SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021978	Protein of unknown function DUF3583
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000026474	transcription factor PML

References

(Earliest) J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
(Latest) J:192771 Ito K, et al., A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012 Sep;18(9):1350-8
All references(102)

Other accession IDs

MGD-MRK-26102, MGI:2143109, MGI:2443400