About   Help   FAQ
Pml Gene Detail
Summary
  • Symbol
    Pml
  • Name
    promyelocytic leukemia
  • Synonyms
    1200009E24Rik, Trim19
  • Feature Type
    protein coding gene
  • IDs
    MGI:104662
    NCBI Gene: 18854
  • Gene Overview
    MyGene.info: PML
Location & Maps
more
  • Sequence Map
    Chr9:58218076-58249786 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.63 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PML, promyelocytic leukemia
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PML, promyelocytic leukemia
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYL, PP8675, RNF71, TRIM19
  • Links
    NCBI Gene ID: 5371
    neXtProt AC: NX_P29590

  • Chr Location
    15q24.1; chr15:73994673-74047819 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033332 VEGA Gene Model | MGI Sequence Detail 31711 C57BL/6J ±  kb
transcript OTTMUST00000083649 VEGA | MGI Sequence Detail 4481 Not Applicable  
polypeptide OTTMUSP00000044973 VEGA | MGI Sequence Detail 885 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    117 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR000315 B-box-type zinc finger
    IPR021978 Protein of unknown function DUF3583
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
less
  • All nucleic 30
    Genomic 4
    cDNA 24
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-26102, MGI:2143109, MGI:2443400
References
more
  • Summaries
    All 119
    Developmental Gene Expression 12
    Diseases 4
    Gene Ontology 35
    Phenotypes 73
  • Earliest
    J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
  • Latest
    J:234118 Constanzo JD, et al., Pias1 is essential for erythroid and vascular development in the mouse embryo. Dev Biol. 2016 Jul 1;415(1):98-110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory