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Pml Gene Detail
Summary
  • Symbol
    Pml
  • Name
    promyelocytic leukemia
  • Synonyms
    1200009E24Rik, Trim19
  • Feature Type
    protein coding gene
  • IDs
    MGI:104662
    NCBI Gene: 18854
  • Gene Overview
    MyGene.info: PML
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:58218076-58249786 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.63 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PML, promyelocytic leukemia
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PML, promyelocytic leukemia
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYL, PP8675, RNF71, TRIM19
  • Links
    NCBI Gene ID: 5371
    neXtProt AC: NX_P29590
    UniProt: P29590

  • Chr Location
    15q24.1; chr15:73994673-74047819 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033332 VEGA Gene Model | MGI Sequence Detail 31711 C57BL/6J ±  kb
    transcript OTTMUST00000083649 VEGA | MGI Sequence Detail 4481 Not Applicable  
    polypeptide OTTMUSP00000044973 VEGA | MGI Sequence Detail 885 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      117 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000315 B-box-type zinc finger
      IPR021978 Protein of unknown function DUF3583
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR001841 Zinc finger, RING-type
      IPR017907 Zinc finger, RING-type, conserved site
    Molecular
    Reagents
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    • All nucleic 30
      Genomic 4
      cDNA 24
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
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    MGD-MRK-26102, MGI:2143109, MGI:2443400
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 38
      Phenotypes 80
    • Earliest
      J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
    • Latest
      J:256973 Guarnerio J, et al., A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. Nat Commun. 2018 Jan 4;9(1):66

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory