Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables SMAD binding activity. Involved in several processes, including defense response to symbiont; regulation of gene expression; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and cellular response to cytokine stimulus. Located in PML body; cytosol; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold).