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Pla2g2a Gene Detail
Summary
  • Symbol
    Pla2g2a
  • Name
    phospholipase A2, group IIA (platelets, synovial fluid)
  • Synonyms
    EF, Enhancing factor, modifier of Min1
Location & Maps
more
  • Sequence Map
    Chr4:138831860-138835186 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3327 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    15 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from multigenic genotypes
    46 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Spontaneous
    2
  • Targeted
    1
  • Transgenic
    7
  • Genomic Mutations
    3 involving Pla2g2a
Mutations in this gene influence susceptibility to intestinal adenomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010068 VEGA Gene Model | MGI Sequence Detail 3327 C57BL/6J ±  kb
transcript OTTMUST00000023407 VEGA | MGI Sequence Detail 788 Not Applicable  
polypeptide OTTMUSP00000063758 VEGA | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    69 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012799 phospholipase A2, membrane associated
  • EC
  • InterPro Domains
    IPR001211 Phospholipase A2
    IPR033112 Phospholipase A2, aspartic acid active site
    IPR016090 Phospholipase A2 domain
    IPR033113 Phospholipase A2, histidine active site
Molecular
Reagents
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  • All nucleic 32
    Genomic 6
    cDNA 23
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12352, MGD-MRK-26080, MGI:97049
References
more
  • Summaries
    All 89
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 46
  • Earliest
    J:1879 Moser AR, et al., The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol. 1992 Mar;116(6):1517-26
  • Latest
    J:223733 Duchez AC, et al., Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory