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Pla2g2a Pseudogene Detail
Summary
  • Symbol
    Pla2g2a
  • Name
    phospholipase A2, group IIA (platelets, synovial fluid)
  • Synonyms
    EF, Enhancing factor, modifier of Min1
  • Feature Type
    polymorphic pseudogene
  • IDs
    MGI:104642
    NCBI Gene: 18780
  • Gene Overview
    MyGene.info: PLA2G2A
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138559168-138562497 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104642
polymorphic pseudogene Chr4:138559168-138562500 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009943
polymorphic pseudogene Chr4:141618742-141622071 (+)
A/J MGP_AJ_G0009927
polymorphic pseudogene Chr4:135542164-135545493 (+)
AKR/J MGP_AKRJ_G0009910
polymorphic pseudogene Chr4:139420219-139423542 (+)
BALB/cJ MGP_BALBcJ_G0009911
polymorphic pseudogene Chr4:136217521-136220852 (+)
C3H/HeJ MGP_C3HHeJ_G0009843
polymorphic pseudogene Chr4:139792914-139796237 (+)
C57BL/6NJ MGP_C57BL6NJ_G0010160
polymorphic pseudogene Chr4:146643354-146646683 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008953
polymorphic pseudogene Chr4:128522662-128525995 (+)
CAST/EiJ MGP_CASTEiJ_G0009661
polymorphic pseudogene Chr4:137968995-137972331 (+)
CBA/J MGP_CBAJ_G0009817
polymorphic pseudogene Chr4:150860650-150863973 (+)
DBA/2J MGP_DBA2J_G0009845
polymorphic pseudogene Chr4:135925528-135928859 (+)
FVB/NJ MGP_FVBNJ_G0009863
polymorphic pseudogene Chr4:134953702-134957029 (+)
LP/J MGP_LPJ_G0009940
polymorphic pseudogene Chr4:141704020-141707349 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009829
polymorphic pseudogene Chr4:154805420-154808749 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0010131
polymorphic pseudogene Chr4:139953062-139956391 (+)
PWK/PhJ MGP_PWKPhJ_G0009582
polymorphic pseudogene Chr4:132787909-132791240 (+)
SPRET/EiJ MGP_SPRETEiJ_G0009413
polymorphic pseudogene Chr4:135709760-135713092 (+)
WSB/EiJ MGP_WSBEiJ_G0009765
polymorphic pseudogene Chr4:140194989-140198312 (+)



Homology
more
  • Human Ortholog
    PLA2G2A, phospholipase A2 group IIA
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G2A, phospholipase A2 group IIA
  • Synonyms
    MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2
  • Links
    NCBI Gene ID: 5320
    neXtProt AC: NX_P14555
    UniProt: P14555

  • Chr Location
    1p36.13; chr1:19975431-19980439 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PLA2G2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene influence susceptibility to intestinal adenomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058908 Ensembl Gene Model | MGI Sequence Detail 3330 C57BL/6J ±  kb
    transcript ENSMUST00000135748 Ensembl | MGI Sequence Detail 788 Not Applicable  
    polypeptide ENSMUSP00000138550 Ensembl | MGI Sequence Detail 147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 6
      cDNA 25
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12352, MGD-MRK-26080, MGI:97049
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 58
    • Earliest
      J:1879 Moser AR, et al., The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol. 1992 Mar;116(6):1517-26
    • Latest
      J:289292 Duchez AC, et al., Respective contribution of cytosolic phospholipase A2alpha and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis. Prostaglandins Other Lipid Mediat. 2019 Aug;143:106340

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/12/2021
    MGI 6.17
    The Jackson Laboratory