Pla2g2a
Gene Detail

Symbol Name ID

Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) MGI:104642

BioType Conflict

Synonyms

EF, Enhancing factor, modifier of Min1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr4:138831860-138835186 bp, + strand From VEGA annotation of GRCm38   3327 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g2a

Alleles and phenotypes

All alleles(2) : Spontaneous(2)
 

Mutations in this gene influences tumor susceptibility.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	lipid catabolic process, lipid metabolic process, ...
Component	membrane, mitochondrion
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (148)    Tissues (139)    Images (2)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
Northern blot	8
RT-PCR	46

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(6) cDNA(23) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010068 (Evidence)
Ensembl Gene Model	ENSMUSG00000058908 (Evidence)
Entrez Gene	18780 (Evidence)
UniGene	4675
DFCI	TC1576245
DoTS	DT.526216, DT.55117856
NIA Mouse Gene Index	U005006
EC	3.1.1.4
International Mouse Knockout Project Status	Pla2g2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010068	VEGA Gene Model | MGI Sequence Detail	3327	C57BL/6J
transcript	OTTMUST00000023407	VEGA | MGI Sequence Detail	788	Not Applicable
polypeptide	P31482	UniProt | EBI | MGI Sequence Detail	146	Not Applicable

All sequences(27) RefSeq(4) UniProt(1)

Polymorphisms

All PCR and RFLP(8) : PCR(2) RFLP(6) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016090	Phospholipase A2
InterPro	IPR013090	Phospholipase A2, active site
InterPro	IPR001211	Phospholipase A2, eukaryotic
Protein Ontology	PR:000012799	phospholipase A2, membrane associated

Graphical View of Protein Domain Structure

References

(Earliest) J:1879 Moser AR, et al., The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol. 1992 Mar;116(6):1517-26
(Latest) J:181418 Wei Y, et al., sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse model. Invest Ophthalmol Vis Sci. 2011 Jun;52(7):4780-8
All references(90)

Other accession IDs

MGD-MRK-12352, MGD-MRK-26080, MGI:97049