Tle4 MGI Mouse Gene Detail - MGI:104633 - transducin-like enhancer of split 4

Tle4 Gene Detail

Symbol

Tle4
Name

transducin-like enhancer of split 4
Synonyms

5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4

Feature Type

protein coding gene
IDs

MGI:104633
NCBI Gene: 21888
Gene Overview

MyGene.info: TLE4

Sequence Map

Chr19:14448072-14598051 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

149980 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 9.11 cM
Mapping Data

4 experiments

Human Ortholog

TLE4, transducin like enhancer of split 4

Vertebrate Orthologs

9

Human Ortholog

TLE4, transducin like enhancer of split 4
Orthology source: HomoloGene, HGNC
Synonyms

BCE1, BCE-1, ESG, ESG4, E(spI), Grg-4, GRG4
Links

HGNC:11840

NCBI Gene ID: 7091

neXtProt AC: NX_Q04727

UniProt: Q04727
Chr Location

9q21.31; chr9:79571773-79726882 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38259
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TLE4
Protein SuperFamily

transducin-like enhancer protein
Gene Tree

Tle4

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Phenotype Summary

30 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Gene trapped

45
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for a knock-out allele are runted and die around 4 weeks of age with leukocytopenia, B cell lymphopenia, reduced bone mineralization and reduced hematopoietic stem cell number and function.

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All GO Annotations

20
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

402
Tissues

188
cDNA Data

86
Literature Summary

63

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TLE4Z1

Xenbase tle4

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Tle4 interacts with 339 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

55
RefSeq

12
UniProt

7
CCDS

CCDS50399.1
UniGene

103638

Ensembl

ENSMUSG00000024642 (Evidence)
NCBI Gene

21888

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024642	Ensembl Gene Model \| MGI Sequence Detail	149980	C57BL/6J	± kb
transcript	ENSMUST00000052011	Ensembl \| MGI Sequence Detail	4555	Not Applicable
polypeptide	ENSMUSP00000057527	Ensembl \| MGI Sequence Detail	773	Not Applicable

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SNPs within 2kb

939 from dbSNP Build 142

RFLP

1

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UniProt

7 Sequences
Protein Ontology

PR:000016375 transducin-like enhancer protein 4

(term hierarchy)
InterPro Domains

IPR005617 Groucho/TLE, N-terminal Q-rich domain

IPR009146 Groucho/transducin-like enhancer

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR017986 WD40-repeat-containing domain

IPR015943 WD40/YVTN repeat-like-containing domain

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All nucleic 89

cDNA 86

Primer pair 2

Other 1

Microarray probesets 5

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MGD-MRK-26070, MGD-MRK-28129, MGD-MRK-28130, MGI:104835, MGI:104836, MGI:1917740, MGI:1930703, MGI:2147460

Summaries

All 105

Developmental Gene Expression 63

Gene Ontology 11

Phenotypes 10
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:239715 Galazo MJ, et al., Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/08/2017 MGI 6.10