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Tle4 Gene Detail
Summary
  • Symbol
    Tle4
  • Name
    transducin-like enhancer of split 4
  • Synonyms
    5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104633
    NCBI Gene: 21888
  • Gene Overview
    MyGene.info: TLE4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:14448072-14598051 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      149980 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 9.11 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TLE4, transducin like enhancer of split 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TLE4, transducin like enhancer of split 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCE1, BCE-1, ESG, ESG4, E(spI), Grg-4, GRG4
  • Links
    NCBI Gene ID: 7091
    neXtProt AC: NX_Q04727
    UniProt: Q04727

  • Chr Location
    9q21.31; chr9:79571773-79726882 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted and die around 4 weeks of age with leukocytopenia, B cell lymphopenia, reduced bone mineralization and reduced hematopoietic stem cell number and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    402
  • Tissues
    188
  • cDNA Data
    86
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024642 Ensembl Gene Model | MGI Sequence Detail 149980 C57BL/6J ±  kb
    transcript ENSMUST00000052011 Ensembl | MGI Sequence Detail 4555 Not Applicable  
    polypeptide ENSMUSP00000057527 Ensembl | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      939 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 86
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26070, MGD-MRK-28129, MGD-MRK-28130, MGI:104835, MGI:104836, MGI:1917740, MGI:1930703, MGI:2147460
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 67
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:255065 Sgourdou P, et al., Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Sci Rep. 2017 Mar 8;7:43708
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory