Tle4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tle4
transducin-like enhancer of split 4
MGI:104633

51 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tle4^em1(IMPC)Mbp/Tle4^em1(IMPC)Mbp C57BL/6NCrl-Tle4^em1(IMPC)Mbp/Mmucd	abnormal auditory brainstem response	J:211773
	abnormal cholesterol homeostasis	J:211773
	abnormal eye morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal rectum morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	decreased bone mineral content	J:211773
	decreased grip strength	J:211773
	decreased heart weight	J:211773
	decreased lean body mass	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	enlarged liver	J:211773
	enlarged lymph nodes	J:211773
	enlarged spleen	J:211773
	impaired glucose tolerance	J:211773
	increased total body fat amount	J:211773
	male infertility	J:211773
	small kidney	J:211773
Tle4^tm1.2Dasw/Tle4^tm1.2Dasw B6.129S6(Cg)-Tle4^tm1.2Dasw	abnormal hematopoietic stem cell physiology	J:219243
	abnormal long bone epiphyseal plate morphology	J:219243
	abnormal long bone epiphyseal plate proliferative zone	J:219243
	abnormal long bone hypertrophic chondrocyte zone	J:219243
	abnormal lymphopoiesis	J:219243
	abnormal thymus morphology	J:219243
	decreased B cell number	J:219243
	decreased body weight	J:219243
	decreased bone marrow cell number	J:219243
	decreased bone mineral content	J:219243
	decreased common myeloid progenitor cell number	J:219243
	decreased compact bone thickness	J:219243
	decreased DN2 thymocyte number	J:219243
	decreased double-positive T cell number	J:219243
	decreased follicular B cell number	J:219243
	decreased hematopoietic stem cell number	J:219243
	decreased leukocyte cell number	J:219243
	decreased long bone epiphyseal plate size	J:219243
	decreased lymphocyte cell number	J:219243
	decreased pre-pro B cell number	J:219243
	decreased spleen B cell follicle number	J:219243
	decreased trabecular bone mass	J:219243
	normal immune system phenotype	J:219243
	increased NK T cell number	J:219243
	increased thymocyte apoptosis	J:219243
	postnatal growth retardation	J:219243
	premature death	J:219243
	spleen hypoplasia	J:219243
	thymus atrophy	J:219243
	thymus hypoplasia	J:219243

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23