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Penk
Gene Detail
 Symbol
Name
ID
Penk
preproenkephalin
MGI:104629
Synonyms ENK, Penk, Penk1, PPA
Feature Type protein coding gene
Genetic Map
Chromosome 4
2.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:4133531-4138819 bp, - strand
From VEGA annotation of GRCm38

  5289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: proenkephalin
Gene Tree: Penk

Human
homologs
Human Homolog PENK, proenkephalin
NCBI Gene ID 5179
neXtProt AC  NX_P01210
Human Chr (Location)  8q23-q24; chr8:56440954-56446723 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
 
Interactions
Penk interacts with 108 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process aggressive behavior, behavioral fear response, ...
Component extracellular region
Function opioid peptide activity
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (245)    Tissues (215)    Images (40)
Theiler Stages: 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 188
RT-PCR 50
RNase protection 7
cDNA source data(69)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(2) cDNA(77) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004406 (Evidence)
Ensembl Gene ModelENSMUSG00000045573 (Evidence)
Entrez Gene18619 (Evidence)
UniGene475097
DFCITC1579360
NIA Mouse Gene IndexU024814
Consensus CDS ProjectCCDS17946.1
International Mouse Knockout Project StatusPenk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004406 VEGA Gene Model | MGI Sequence Detail 5289 C57BL/6J ±  kb
transcript OTTMUST00000009988 VEGA | MGI Sequence Detail 1449 Not Applicable 
polypeptide OTTMUSP00000004782 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006024 Opioid neuropeptide precursor
InterPro IPR000703 Proenkephalin A
Protein Ontology PR:000012544 proenkephalin-A
References (Earliest) J:8253 Zurawski G, et al., Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science. 1986 May 9;232(4751):772-5
(Latest) J:206284 Lu KM, et al., Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
All references(89)
Other
accession IDs
MGD-MRK-26066, MGI:1889826, MGI:2140244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory