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Penk Gene Detail
Summary
  • Symbol
    Penk
  • Name
    preproenkephalin
  • Synonyms
    ENK, Penk, Penk1, PPA
  • Feature Type
    protein coding gene
  • IDs
    MGI:104629
    NCBI Gene: 18619
Location & Maps
more
  • Genetic Map
    Chromosome 4, 2.31 cM
  • Mapping Data
    5 experiments
Homology
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  • Human Ortholog
    PENK, proenkephalin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PENK, proenkephalin
    Orthology source: HomoloGene
  • Synonyms
    PE, PENK-A
  • Links
    NCBI Gene ID: 5179
    neXtProt AC: NX_P01210

  • Chr Location
    8q12.1; chr8:56440954-56446723 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004406 VEGA Gene Model | MGI Sequence Detail 5289 C57BL/6J ±  kb
transcript OTTMUST00000009988 VEGA | MGI Sequence Detail 1449 Not Applicable  
polypeptide OTTMUSP00000004782 VEGA | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 85
    Genomic 2
    cDNA 77
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-26066, MGI:1889826, MGI:2140244
References
more
  • Summaries
    All 96
    Developmental Gene Expression 45
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:8253 Zurawski G, et al., Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science. 1986 May 9;232(4751):772-5
  • Latest
    J:229471 Branchfield K, et al., Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory