About   Help   FAQ
Penk
Gene Detail
Symbol

Name
ID
Penk
preproenkephalin
MGI:104629
Synonyms
ENK, Penk, Penk1, PPA
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:4133531-4138819 bp, - strand
From VEGA annotation of GRCm38

  5289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PENK
Protein SuperFamily: proenkephalin
Gene Tree: Penk

Human
homologs
PENK, proenkephalin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5179
neXtProt AC: NX_P01210

Human Synonyms: PE, PENK-A

Human Chr (Location): 8q23-q24; chr8:56440954-56446723 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
 
Interactions
Penk interacts with 108 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process aggressive behavior, behavioral fear response, ...
Component axon, axon terminus, ...
Function opioid peptide activity
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (245)    Tissues (215)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
RT-PCR 50
RNase protection 7
cDNA source data(69)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PENK ; Xenbase penk ; ZFIN penka, penkb    NEW 
Molecular
reagents
All nucleic(85) Genomic(2) cDNA(77) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004406 (Evidence)
Ensembl Gene Model ENSMUSG00000045573 (Evidence)
Entrez Gene 18619 (Evidence)
UniGene 475097
DFCI TC1579360
NIA Mouse Gene Index U024814
Consensus CDS Project CCDS17946.1
International Mouse Phenotyping Consortium Status Penk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004406 VEGA Gene Model | MGI Sequence Detail 5289 C57BL/6J ±  kb
transcript OTTMUST00000009988 VEGA | MGI Sequence Detail 1449 Not Applicable 
polypeptide OTTMUSP00000004782 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006024 Opioid neuropeptide precursor
InterPro IPR000703 Proenkephalin A
Protein Ontology PR:000012544 proenkephalin-A
References
(Earliest) J:8253 Zurawski G, et al., Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science. 1986 May 9;232(4751):772-5
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(93)
Other
accession IDs
MGD-MRK-26066, MGI:1889826, MGI:2140244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory