Ccr1
Gene Detail

Symbol Name ID

Ccr1 chemokine (C-C motif) receptor 1 MGI:104618

Synonyms

Cmkbr1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:123962126-123968692 bp, - strand From NCBI annotation of GRCm38   6567 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr1

Human homologs

Human Homolog		CCR1, chemokine (C-C motif) receptor 1
NCBI Gene ID		1230
neXtProt AC		NX_P32246
Human Synonyms		CD191, CKR1, CKR-1, CMKBR1, HM145, MIP1aR, SCYAR1
Human Chr (Location)		3p21; chr3:46243200-46249832 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	calcium ion transport, cell-cell signaling, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	C-C chemokine binding, C-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (1)
Theiler Stages: 13, 20

Assay Type	Results
RNase protection	5

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(16) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000025804 (Evidence)
Entrez Gene	12768 (Evidence)
UniGene	274927
DFCI	TC1582465
DoTS	DT.55209071
NIA Mouse Gene Index	U031484
Consensus CDS Project	CCDS23666.1
International Mouse Knockout Project Status	Ccr1

Sequences

Length	Strain/Species
genomic	12768	NCBI Gene Model | MGI Sequence Detail	6567	C57BL/6J
transcript	NM_009912	RefSeq | MGI Sequence Detail	2831	C57BL/6
polypeptide	P51675	UniProt | EBI | MGI Sequence Detail	355	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002236	CC chemokine receptor 1
InterPro	IPR000355	Chemokine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001254	chemokine receptor CCR1

Graphical View of Protein Domain Structure

References

(Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:193779 Taddei SR, et al., The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice. Bone. 2013 Jan;52(1):259-67
All references(105)

Other accession IDs

MGD-MRK-26055