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Ccr1
Gene Detail
 Symbol
Name
ID
Ccr1
chemokine (C-C motif) receptor 1
MGI:104618
Synonyms Cmkbr1
Feature Type protein coding gene
Genetic Map
Chromosome 9
75.05 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:123962126-123968692 bp, - strand
From NCBI annotation of GRCm38

  6567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr1

Human
homologs
Human Homolog CCR1, chemokine (C-C motif) receptor 1
NCBI Gene ID 1230
neXtProt AC  NX_P32246
Human Synonyms  CD191, CKR1, CKR-1, CMKBR1, HM145, MIP1aR, SCYAR1
Human Chr (Location)  3p21; chr3:46201709-46208341 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.
 
Interactions
Ccr1 interacts with 202 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process calcium ion transport, cell-cell signaling, ...
Component cytosol, external side of plasma membrane, ...
Function C-C chemokine binding, C-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (1)
Theiler Stages: 13, 20
Assay TypeResults
RNase protection 5
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(16) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000025804 (Evidence)
Entrez Gene12768 (Evidence)
UniGene274927
DFCITC1582465
DoTSDT.55209071
NIA Mouse Gene IndexU031484
Consensus CDS ProjectCCDS23666.1
International Mouse Knockout Project StatusCcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12768 NCBI Gene Model | MGI Sequence Detail 6567 C57BL/6J ±  kb
transcript NM_009912 RefSeq | MGI Sequence Detail 2831 C57BL/6 
polypeptide P51675 UniProt | EBI | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(57 from dbSNP Build 137)    SNPs within 2kb including multiple locations(73)
Protein-related
information
ResourceIDDescription
InterPro IPR002236 CC chemokine receptor 1
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001254 C-C chemokine receptor type 1
Graphical View of Protein Domain Structure
References (Earliest) J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
(Latest) J:207311 Bignon A, et al., CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol. 2014 Feb 1;192(3):886-96
All references(108)
Other
accession IDs
MGD-MRK-26055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory