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Ccr1tm1Gao
Targeted Allele Detail
Summary
Symbol: Ccr1tm1Gao
Name: C-C motif chemokine receptor 1; targeted mutation 1, Ji-Liang Gao
MGI ID: MGI:1931850
Synonyms: CCR1-
Gene: Ccr1  Location: Chr9:123762163-123768729 bp, - strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance: Ccr1tm1Gao page
Ccr1tm1Gao/Ccr1tm1Gao and control mice underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41324
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced open reading frame sequences that correspond to 33% of the protein, from the third to the fifth transmembrane segment. Transcript was not detected in neutrophils of homozygous mutant animals. (J:41324)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ccr1tm1Gao
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Ccr1 Mutation:  38 strains or lines available
References
Original:  J:41324 Gao JL, et al., Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med. 1997 Jun 2;185(11):1959-68
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory