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Procr
Gene Detail
 Symbol
Name
ID
Procr
protein C receptor, endothelial
MGI:104596
Synonyms Ccca, EPCR
Feature Type protein coding gene
Genetic Map
Chromosome 2
77.26 cM, cytoband H1-3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:155751117-155755471 bp, + strand
From VEGA annotation of GRCm38

  4355 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Procr

Human
homologs
Human Homolog PROCR, protein C receptor, endothelial
NCBI Gene ID 10544
neXtProt AC  NX_Q9UNN8
Human Synonyms  CCCA, CCD41, EPCR
Human Chr (Location)  20q11.2; chr20:35171154-35215968 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
 
Homozygous null mutants exhibit placental thrombosis, small size, incomplete embryo turning, and lethality by embryonic day 10.5, whereas mice with a mutation that results in a severe deficiency of gene product are viable.
 
Phenotype Images(1)
Interactions
Procr interacts with 85 markers (Mir1b, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process antigen processing and presentation, blood coagulation, ...
Component centrosome, extracellular vesicular exosome, ...
Function protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (9)   
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 28
Assay TypeResults
RT-PCR 9
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016132 (Evidence)
Ensembl Gene ModelENSMUSG00000027611 (Evidence)
Entrez Gene19124 (Evidence)
UniGene3243
DFCITC1579813, TC1669540
DoTSDT.101364766, DT.531823
NIA Mouse Gene IndexU002706
Consensus CDS ProjectCCDS16954.1
International Mouse Knockout Project StatusProcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016132 VEGA Gene Model | MGI Sequence Detail 4355 C57BL/6J ±  kb
transcript OTTMUST00000038558 VEGA | MGI Sequence Detail 1597 Not Applicable 
polypeptide OTTMUSP00000017260 VEGA | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015669 Endothelial protein C receptor
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000001347 endothelial protein C receptor
References (Earliest) J:22114 Rothbarth K, et al., cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein. J Cell Sci. 1993 Jan;104(Pt 1):19-30
(Latest) J:200026 Schaffner F, et al., Endothelial protein C receptor function in murine and human breast cancer development. PLoS One. 2013;8(4):e61071
All references(53)
Other
accession IDs
MGD-MRK-24087, MGD-MRK-26030, MGI:2138904

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory