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Rapgef1 Gene Detail
Summary
  • Symbol
    Rapgef1
  • Name
    Rap guanine nucleotide exchange factor (GEF) 1
  • Synonyms
    4932418O06Rik, C3G, Grf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104580
    NCBI Gene: 107746
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:29509732-29630376 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 20.32 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    618 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104580
protein coding gene Chr2:29509732-29630990 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025540
protein coding gene Chr2:27768249-27897250 (+)
A/J MGP_AJ_G0025517
protein coding gene Chr2:26689036-26809893 (+)
AKR/J MGP_AKRJ_G0025487
protein coding gene Chr2:27582101-27707983 (+)
BALB/cJ MGP_BALBcJ_G0025513
protein coding gene Chr2:26820996-26941552 (+)
C3H/HeJ MGP_C3HHeJ_G0025274
protein coding gene Chr2:27514897-27639970 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025957
protein coding gene Chr2:28660678-28799612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023367
protein coding gene Chr2:25483148-25602703 (+)
CAST/EiJ MGP_CASTEiJ_G0024737
protein coding gene Chr2:27410358-27532992 (+)
CBA/J MGP_CBAJ_G0025252
protein coding gene Chr2:29655924-29787450 (+)
DBA/2J MGP_DBA2J_G0025385
protein coding gene Chr2:26487492-26608721 (+)
FVB/NJ MGP_FVBNJ_G0025347
protein coding gene Chr2:26286894-26411977 (+)
LP/J MGP_LPJ_G0025471
protein coding gene Chr2:27694520-27826321 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025378
protein coding gene Chr2:29605441-29737334 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026016
protein coding gene Chr2:27498092-27631201 (+)
PWK/PhJ MGP_PWKPhJ_G0024484
protein coding gene Chr2:26310512-26434295 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024284
protein coding gene Chr2:27595027-27715756 (+)
WSB/EiJ MGP_WSBEiJ_G0024806
protein coding gene Chr2:27630017-27755230 (+)



Homology
more
  • Human Ortholog
    RAPGEF1, Rap guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAPGEF1, Rap guanine nucleotide exchange factor 1
  • Synonyms
    C3G, GRF2
  • Links
    NCBI Gene ID: 2889
    neXtProt AC: NX_Q13905
    UniProt: Q13905

  • Chr Location
    9q34.13; chr9:131576770-131740076 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before E7.5. Mice homozygous for a hypomorphic gene trap allele show embryonic lethality during organogenesis, altered neuroepithelium morphology, vascular maturation defects, hemorrhage, and reduced cell migration and adhesion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107746 NCBI Gene Model | MGI Sequence Detail 120645 C57BL/6J ±  kb
    transcript NM_001039086 RefSeq | MGI Sequence Detail 6233 ZRU/MplStud  
    polypeptide NP_001034176 RefSeq | MGI Sequence Detail 1224 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000013726 Rap guanine nucleotide exchange factor 1
    • InterPro Domains
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 201
      cDNA 197
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26014, MGI:2444538
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:26202 Schumacher C, et al., The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. J Biol Chem. 1995 Jun 23;270(25):15341-7
    • Latest
      J:331698 Ishii K, et al., Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation. Mol Cell Neurosci. 2022 Nov 23;124:103794

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory