Rapgef1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rapgef1
Rap guanine nucleotide exchange factor (GEF) 1
MGI:104580

13 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rapgef1^{Gt(pGT1.8geo)5Pgr}/Rapgef1^{Gt(pGT1.8geo)5Pgr} involves: 129	abnormal embryonic neuroepithelium morphology	J:119299
Rapgef1^{Gt(pGT1.8geo)5Pgr}/Rapgef1^{Gt(pGT1.8geo)5Pgr} involves: 129/Sv * C57BL/6 * Swiss	abnormal brain vasculature morphology	J:80219
	abnormal cell adhesion	J:80219
	abnormal nervous system morphology	J:80219
	abnormal vascular smooth muscle morphology	J:80219
	decreased fibroblast cell migration	J:80219
	edema	J:80219
	embryonic lethality during organogenesis, complete penetrance	J:80219
	hemorrhage	J:80219
	vascular smooth muscle hypoplasia	J:80219
Rapgef1^{tm1b(KOMP)Wtsi}/Rapgef1⁺ C57BL/6N-Rapgef1^{tm1b(KOMP)Wtsi}/J	abnormal retina morphology	J:211773
Rapgef1^{tm1b(KOMP)Wtsi}/Rapgef1^{tm1b(KOMP)Wtsi} C57BL/6N-Rapgef1^{tm1b(KOMP)Wtsi}/J	preweaning lethality, complete penetrance	J:211773
Rapgef1^tm1Mats/Rapgef1^tm1Mats involves: 129P2/OlaHsd * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:77323

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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