Limk1
Gene Detail

Symbol Name ID

Limk1 LIM-domain containing, protein kinase MGI:104572

Feature Type

protein coding gene

Genetic Map

Chromosome 5

74.73 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr5:134656039-134688590 bp, - strand From VEGA annotation of GRCm38   32552 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LIM protein kinase
Gene Tree: Limk1

Human homologs

Human Homolog		LIMK1, LIM domain kinase 1
NCBI Gene ID		3984
neXtProt AC		NX_P53667
Human Synonyms		LIMK, LIMK-1
Human Chr (Location)		7q11.23; chr7:73498107-73536855 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene display an abnormal actin cytoskeleton in neurons of the central nervous system and structural abnormalities of the dendritic spines. Long term potentiation is altered and behavioral anomalies are seen.

 
Human Diseases Modeled Using Mouse Limk1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	negative regulation of ubiquitin-protein ligase activity, phosphorylation, ...
Component	axonal growth cone, cytoplasm, ...
Function	ATP binding, heat shock protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (266)    Tissues (210)    Images (100)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	94
RNA in situ	85
Northern blot	18
Western blot	8
RT-PCR	61

cDNA source data(56)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(70) Genomic(10) cDNA(56) Primer pair(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026202 (Evidence)
Ensembl Gene Model	ENSMUSG00000029674 (Evidence)
Entrez Gene	16885 (Evidence)
UniGene	15409
DFCI	TC1583565, TC1583668, TC1716596
DoTS	DT.101131721, DT.101206076, DT.101242293, DT.101371174, DT.101382625, DT.110673139, DT.486812, DT.91290456
NIA Mouse Gene Index	U026804
EC	2.7.11.1
Consensus CDS Project	CCDS19724.1
International Mouse Knockout Project Status	Limk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026202	VEGA Gene Model | MGI Sequence Detail	32552	C57BL/6J
transcript	OTTMUST00000064766	VEGA | MGI Sequence Detail	3323	Not Applicable
polypeptide	OTTMUSP00000032203	VEGA | MGI Sequence Detail	647	Not Applicable

All sequences(65) RefSeq(2) UniProt(8)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(156 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009816	LIM domain kinase 1

References

(Earliest) J:37753 Bernard O, et al., Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 1994 Nov;5(11):1159-71
(Latest) J:193784 Kawano T, et al., LIM kinase 1 deficient mice have reduced bone mass. Bone. 2013 Jan;52(1):70-82
All references(79)

Other accession IDs

MGD-MRK-26006