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Limk1
Gene Detail
Symbol

Name
ID
Limk1
LIM-domain containing, protein kinase
MGI:104572
Feature Type
protein coding gene
Genetic Map
Chromosome 5
74.73 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr5:134656039-134688590 bp, - strand
From VEGA annotation of GRCm38

  32552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LIMK1
Protein SuperFamily: LIM protein kinase
Gene Tree: Limk1

Human
homologs
LIMK1, LIM domain kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3984
neXtProt AC: NX_P53667

Human Synonyms: LIMK, LIMK-1

Human Chr (Location): 7q11.23; chr7:74083777-74122525 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Limk1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display an abnormal actin cytoskeleton in neurons of the central nervous system and structural abnormalities of the dendritic spines. Long term potentiation is altered and behavioral anomalies are seen.
 
Human Diseases Modeled in Mice Using Limk1 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Limk1 interacts with 261 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process negative regulation of ubiquitin-protein transferase activity, phosphorylation, ...
Component axonal growth cone, cytoplasm, ...
Function ATP binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (259)    Tissues (205)    Images (100)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 94
RNA in situ 85
Northern blot 18
Western blot 8
RT-PCR 54
cDNA source data(55)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase limk1 ; ZFIN limk1a    NEW 
Molecular
reagents
All nucleic(69) Genomic(10) cDNA(55) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026202 (Evidence)
Ensembl Gene Model ENSMUSG00000029674 (Evidence)
Entrez Gene 16885 (Evidence)
UniGene 15409
DFCI TC1716596, TC1583668, TC1583565
DoTS DT.101382625, DT.101371174, DT.101242293, DT.101206076, DT.101131721, DT.486812, DT.110673139, DT.91290456
NIA Mouse Gene Index U026804
EC 2.7.11.1
Consensus CDS Project CCDS19724.1
International Mouse Phenotyping Consortium Status Limk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026202 VEGA Gene Model | MGI Sequence Detail 32552 C57BL/6J ±  kb
transcript OTTMUST00000064766 VEGA | MGI Sequence Detail 3323 Not Applicable 
polypeptide OTTMUSP00000032203 VEGA | MGI Sequence Detail 647 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(9) UniProt(8)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009816 LIM domain kinase 1
References
(Earliest) J:37753 Bernard O, et al., Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 1994 Nov;5(11):1159-71
(Latest) J:217820 Larabee SM, et al., miRNA-17 Members that Target Bmpr2 Influence Signaling Mechanisms Important for Embryonic Stem Cell Differentiation In Vitro and Gastrulation in Embryos. Stem Cells Dev. 2015 Feb 1;24(3):354-71
All references(83)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-26006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory