Phenotypes Associated with This Genotype

Genotype
MGI:2679324

• Allelic Composition: Limk1^tm1Zpj/Limk1^tm1Zpj
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:86283 )

• impaired learning during learning reversal phase in a Morris water test

abnormal associative learning ( J:86283 )

abnormal cued conditioning behavior ( J:86283 )

• greater response in cued-conditioning fear response

abnormal motor capabilities/coordination/movement ( J:86283 )

abnormal locomotor behavior ( J:86283 )

hyperactivity ( J:86283 )

increased vertical activity ( J:86283 )

nervous system

abnormal brain morphology ( J:86283 )

abnormal hippocampus morphology ( J:86283 )

• size of growth cone in hippocampal neurons greatly reduced

• actin cytoskeleton disrupted

• abnormal clusters of cofilin and actin

• abnormal shape of dendritic spines

abnormal long-term potentiation ( J:86283 )

• long term potentiation by high frequency stimulation enhanced while it was reduced or absent at low frequency

• reduced neurotransmitter release

• effect due to actin perturbation

cellular

abnormal actin cytoskeleton morphology ( J:86283 )

• actin cytoskeleton disrupted in hippocampal cells, with abnormal clusters of cofilin and actin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:86283