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Hcls1 Gene Detail
Summary
  • Symbol
    Hcls1
  • Name
    hematopoietic cell specific Lyn substrate 1
  • Synonyms
    HS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104568
    NCBI Gene: 15163
  • Gene Overview
    MyGene.info: HCLS1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36934983-36963212 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.30 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104568
protein coding gene Chr16:36934983-36963214 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022796
protein coding gene Chr16:35357699-35386716 (+)
A/J MGP_AJ_G0022761
protein coding gene Chr16:33615786-33643927 (+)
AKR/J MGP_AKRJ_G0022733
protein coding gene Chr16:34899331-34928212 (+)
BALB/cJ MGP_BALBcJ_G0022762
protein coding gene Chr16:33719364-33747713 (+)
C3H/HeJ MGP_C3HHeJ_G0022526
protein coding gene Chr16:35016236-35045937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023209
protein coding gene Chr16:36199596-36228683 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020723
protein coding gene Chr16:33979893-34008215 (+)
CAST/EiJ MGP_CASTEiJ_G0022052
protein coding gene Chr16:35137890-35171331 (+)
CBA/J MGP_CBAJ_G0022497
protein coding gene Chr16:37778746-37806934 (+)
DBA/2J MGP_DBA2J_G0022629
protein coding gene Chr16:33511393-33539493 (+)
FVB/NJ MGP_FVBNJ_G0022604
protein coding gene Chr16:33541580-33569729 (+)
LP/J MGP_LPJ_G0022697
protein coding gene Chr16:35064604-35091223 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022623
protein coding gene Chr16:36836043-36868835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023224
protein coding gene Chr16:34847571-34876644 (+)
PWK/PhJ MGP_PWKPhJ_G0021792
protein coding gene Chr16:33912639-33941311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021623
protein coding gene Chr16:34765442-34794630 (+)
WSB/EiJ MGP_WSBEiJ_G0022096
protein coding gene Chr16:34904784-34935566 (+)



Homology
more
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTTNL, HS1, lckBP1, p75
  • Links
    NCBI Gene ID: 3059
    neXtProt AC: NX_P14317
    UniProt: P14317

  • Chr Location
    3q13.33; chr3:121631398-121660948 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022831 Ensembl Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
transcript ENSMUST00000023531 Ensembl | MGI Sequence Detail 2016 Not Applicable  
polypeptide ENSMUSP00000023531 Ensembl | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 4
    cDNA 43

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-26002, MGI:2146629
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
  • Latest
    J:190337 Skokowa J, et al., Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med. 2012 Oct;18(10):1550-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory