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Hcls1 Gene Detail
Summary
  • Symbol
    Hcls1
  • Name
    hematopoietic cell specific Lyn substrate 1
  • Synonyms
    HS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104568
    NCBI Gene: 15163
  • Gene Overview
    MyGene.info: HCLS1
Location & Maps
more
  • Sequence Map
    Chr16:36934983-36963212 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28230 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.30 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTTNL, HS1, lckBP1, p75
  • Links
    NCBI Gene ID: 3059
    neXtProt AC: NX_P14317

  • Chr Location
    3q13; chr3:121631398-121660948 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035773 VEGA Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
transcript OTTMUST00000091538 VEGA | MGI Sequence Detail 2016 Not Applicable  
polypeptide OTTMUSP00000050431 VEGA | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    173 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008474 hematopoietic lineage cell-specific protein
  • InterPro Domains
    IPR028534 Hematopoietic lineage cell-specific protein
    IPR003134 Hs1/Cortactin
    IPR001452 SH3 domain
Molecular
Reagents
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  • All nucleic 46
    Genomic 4
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-26002, MGI:2146629
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
  • Latest
    J:190337 Skokowa J, et al., Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med. 2012 Oct;18(10):1550-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory