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Hcls1
Gene Detail
Symbol

Name
ID
Hcls1
hematopoietic cell specific Lyn substrate 1
MGI:104568
Synonyms
HS1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.30 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:36934983-36963212 bp, + strand
From VEGA annotation of GRCm38

  28230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: HCLS1
Gene Tree: Hcls1

Human
homologs
HCLS1, hematopoietic cell-specific Lyn substrate 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3059
neXtProt AC: NX_P14317

Human Synonyms: CTTNL, HS1, lckBP1, p75

Human Chr (Location): 3q13; chr3:121631398-121660948 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.
 
Interactions
Hcls1 interacts with 97 markers (Mir10a, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin filament polymerization, cellular response to cytokine stimulus, ...
Component cytoplasm, mitochondrion, ...
Function actin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cttn    NEW 
Molecular
reagents
All nucleic(46) Genomic(4) cDNA(42)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035773 (Evidence)
Ensembl Gene Model ENSMUSG00000022831 (Evidence)
Entrez Gene 15163 (Evidence)
UniGene 4091
DFCI TC1577425
DoTS DT.491551
NIA Mouse Gene Index U017083
Consensus CDS Project CCDS37336.1
International Mouse Phenotyping Consortium Status Hcls1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035773 VEGA Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
transcript OTTMUST00000091538 VEGA | MGI Sequence Detail 2016 Not Applicable 
polypeptide OTTMUSP00000050431 VEGA | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(180 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003134 Hs1/Cortactin
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000008474 hematopoietic lineage cell-specific protein
References
(Earliest) J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
(Latest) J:190337 Skokowa J, et al., Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med. 2012 Oct;18(10):1550-9
All references(41)
Other
accession IDs
MGD-MRK-26002, MGI:2146629

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory