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Mef2b
Gene Detail
 Symbol
Name
ID
Mef2b
myocyte enhancer factor 2B
MGI:104526
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:70152778-70167488 bp, + strand
From VEGA annotation of GRCm38

  14711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mef2b

Human
homologs
Human Homolog MEF2B, myocyte enhancer factor 2B
NCBI Gene ID 100271849
neXtProt AC  NX_Q02080
Human Synonyms  RSRFR2
Human Chr (Location)  19p13.11; chr19:19145567-19170289 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mef2b interacts with 37 markers (Mir15b, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component cell junction, cytoplasm, ...
Function histone deacetylase binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (89)    Tissues (65)    Images (14)
Theiler Stages: 15, 17, 18, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 53
Northern blot 8
Western blot 2
RT-PCR 26
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022207 (Evidence)
Ensembl Gene ModelENSMUSG00000079033 (Evidence)
Entrez Gene17259 (Evidence)
DFCITC1588000, TC1594803, TC1596415, TC1650813
DoTSDT.101362550, DT.40159791, DT.87049613, DT.94231732, DT.94264103
Consensus CDS ProjectCCDS22361.1, CCDS40368.1
International Mouse Knockout Project StatusMef2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022207 VEGA Gene Model | MGI Sequence Detail 14711 C57BL/6J ±  kb
transcript OTTMUST00000052774 VEGA | MGI Sequence Detail 1342 Not Applicable 
polypeptide OTTMUSP00000025066 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4)
Polymorphisms RFLP(2) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010310 myocyte-specific enhancer factor 2B
References (Earliest) J:28136 Lyons GE, et al., Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci. 1995 Aug;15(8):5727-38
(Latest) J:187627 She H, et al., Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response. J Neurochem. 2012 Sep;122(6):1203-10
All references(44)
Other
accession IDs
MGD-MRK-25957, MGI:2142554, MGI:3779429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory