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Cntn2 Gene Detail
Summary
  • Symbol
    Cntn2
  • Name
    contactin 2
  • Synonyms
    axonin, D130012K04Rik, TAG-1, TAG1, Tax
  • Feature Type
    protein coding gene
  • IDs
    MGI:104518
    NCBI Gene: 21367
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132437163-132470989 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104518
 protein coding gene Chr1:132437163-132470994 (-)
129S1/SvImJ ENSMUSG00200008056
 protein coding gene Chr1:130002971-130025265 (-)
A/J ENSMUSG00195042233
 protein coding gene Chr1:129106356-129128345 (-)
AKR/J ENSMUSG00220048109
 protein coding gene Chr1:128934202-128956500 (-)
BALB/cJ ENSMUSG00180032086
 protein coding gene Chr1:129652513-129674650 (-)
C3H/HeJ ENSMUSG00175038899
 protein coding gene Chr1:129350882-129372869 (-)
C57BL/6NJ ENSMUSG00215043916
 protein coding gene Chr1:129364612-129386723 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014590
 protein coding gene Chr1:124101420-124141401 (-)
CAST/EiJ ENSTCUG00005035382
 protein coding gene Chr1:128270626-128292749 (-)
CBA/J ENSMUSG00210025373
 protein coding gene Chr1:129247274-129269405 (-)
DBA/2J ENSMUSG00185030930
 protein coding gene Chr1:133601745-133624038 (-)
FVB/NJ ENSMUSG00205036153
 protein coding gene Chr1:128583694-128605827 (-)
JF1/MsJ ENSUMUG00000030772
 protein coding gene Chr1:132768485-132790590 (-)
LP/J ENSMUSG00230037117
 protein coding gene Chr1:133189629-133211735 (-)
NOD/ShiLtJ ENSMUSG00190042461
 protein coding gene Chr1:129260878-129282865 (-)
NZO/HlLtJ ENSMUSG00225017056
 protein coding gene Chr1:136911719-136933695 (-)
PWK/PhJ ENSLUMG00010026049
 protein coding gene Chr1:128377961-128399838 (-)
SPRET/EiJ ENSMSPG00010044986
 protein coding gene Chr1:131182097-131216091 (-)
WSB/EiJ ENSIUOG00005043821
 protein coding gene Chr1:128995808-129018051 (-)



Homology
more
  • Human Ortholog
    CNTN2, contactin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTN2, contactin 2
  • Synonyms
    AXT, EPEO5, FAME5, TAG-1, TAX, TAX1
  • Links
    NCBI Gene ID: 6900
    UniProt: Q02246

  • Chr Location
    1q32.1; chr1:205042937-205078289 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cntn2 mouse models; 1 with human CNTN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutation of this locus results in molecular abnormalities in the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1523
  • Tissues
    341
  • cDNA Data
    18
  • Literature Summary
    275
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21367 NCBI Gene Model | MGI Sequence Detail 33827 C57BL/6J ±  kb
    transcript NM_177129 RefSeq | MGI Sequence Detail 9535 C57BL/6  
    polypeptide Q61330 UniProt | EBI | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 21
      Primer pair 9
      Other 8
      Antibodies 30

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-25949, MGI:2443768
    References
    more
    • Summaries
      All 356
      Developmental Gene Expression 275
      Diseases 2
      Gene Ontology 28
      Phenotypes 43
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378517 Jimenez-Amilburu V, et al., Arhgef7 is essential for granule cell precursor proliferation and migration during cerebellum development. iScience. 2026 Feb 20;29(2):114580
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory