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Cntn2 Gene Detail
Summary
  • Symbol
    Cntn2
  • Name
    contactin 2
  • Synonyms
    axonin, D130012K04Rik, TAG-1, Tax
  • Feature Type
    protein coding gene
  • IDs
    MGI:104518
    NCBI Gene: 21367
Location & Maps
more
  • Sequence Map
    Chr1:132509427-132543256 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33830 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CNTN2, contactin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNTN2, contactin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AXT, FAME5, TAG-1, TAX, TAX1
  • Links
    NCBI Gene ID: 6900
    neXtProt AC: NX_Q02246

  • Chr Location
    1q32.1; chr1:205043202-205078043 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3720
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CNTN2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CNTN2 associations

Human Disease Mouse Models
       Epilepsy, Familial Adult Myoclonic, 5; FAME5   OMIM: 615400
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cntn2
  • Incidental Mutations
Targeted mutation of this locus results in molecular abnormalities in the central nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049393 VEGA Gene Model | MGI Sequence Detail 33830 C57BL/6J ±  kb
transcript OTTMUST00000125915 VEGA | MGI Sequence Detail 7177 Not Applicable  
polypeptide OTTMUSP00000068144 VEGA | MGI Sequence Detail 1040 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 24
    cDNA 19
    Primer pair 1
    Other 4

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-25949, MGI:2443768
References
more
  • Summaries
    All 212
    Developmental Gene Expression 172
    Gene Ontology 22
    Phenotypes 24
  • Earliest
    J:18717 Wolfer DP, et al., Distribution of TAG-1/axonin-1 in fibre tracts and migratory streams of the developing mouse nervous system. J Comp Neurol. 1994 Jul 1;345(1):1-32
  • Latest
    J:227021 Mallika C, et al., Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory