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Ercc5 Gene Detail
Summary
  • Symbol
    Ercc5
  • Name
    excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Synonyms
    Xpg
  • Feature Type
    protein coding gene
  • IDs
    MGI:103582
    NCBI Gene: 22592
  • Gene Overview
    MyGene.info: ERCC5
Location & Maps
more
  • Sequence Map
    Chr1:44147744-44181260 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33517 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.55 cM, cytoband B
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
    Orthology source: HomoloGene
  • Synonyms
    COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
  • Links
    NCBI Gene ID: 2073
    neXtProt AC: NX_P28715

  • Chr Location
    13q33; chr13:102845841-102876001 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ercc5 mouse models; 2 with human ERCC5 associations

Human Disease Mouse Models
       Xeroderma Pigmentosum, Complementation Group G; XPG   OMIM: 278780 View 4 models
       Cerebrooculofacioskeletal Syndrome 3; COFS3   OMIM: 616570
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Ercc5
  • Incidental Mutations
Homozygous null mice display postnatal mortality, severely retarded postnatal growth, impaired small intestine development, reduced organ size, and hypersensitivity to UV irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021431 VEGA Gene Model | MGI Sequence Detail 33517 C57BL/6J ±  kb
transcript OTTMUST00000050813 VEGA | MGI Sequence Detail 3907 Not Applicable  
polypeptide OTTMUSP00000023812 VEGA | MGI Sequence Detail 1170 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    484 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    Genomic 1
    cDNA 82
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-24467
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:29500 Shiomi T, et al., An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. Mutat Res. 1994 Mar;314(2):167-75
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory