Ercc5
Gene Detail

Symbol Name ID

Ercc5 excision repair cross-complementing rodent repair deficiency, complementation group 5 MGI:103582

Synonyms

Xpg

Feature Type

protein coding gene

Genetic Map

Chromosome 1

23.55 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:44147847-44181260 bp, + strand From VEGA annotation of GRCm38   33414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ercc5

Human homologs

Human Homolog		ERCC5, excision repair cross-complementing rodent repair deficiency, complementation group 5
NCBI Gene ID		2073
neXtProt AC		NX_P28715
Human Synonyms		COFS3, ERCM2, UVDR, XPG, XPGC
Human Chr (Location)		13q33; chr13:103498191-103528351 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ERCC5

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygous null mice display postnatal mortality, severely retarded postnatal growth, impaired small intestine development, reduced organ size, and hypersensitivity to UV irradiation.

 
Human Diseases Modeled Using Mouse Ercc5 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	determination of adult lifespan, DNA repair, ...
Component	DNA-directed RNA polymerase II, holoenzyme, holo TFIIH complex, ...
Function	bubble DNA binding, catalytic activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (28)    Tissues (28)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	28

cDNA source data(84)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(1) cDNA(84) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021431 (Evidence)
Ensembl Gene Model	ENSMUSG00000026048 (Evidence)
Entrez Gene	22592 (Evidence)
UniGene	2213
DFCI	TC1578714, TC1608128, TC1685945
DoTS	DT.101165120, DT.101315052, DT.102556635, DT.40185643
NIA Mouse Gene Index	U000231
EC	3.1.-.-
Consensus CDS Project	CCDS35553.1
International Mouse Knockout Project Status	Ercc5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021431	VEGA Gene Model | MGI Sequence Detail	33414	C57BL/6J
transcript	OTTMUST00000050813	VEGA | MGI Sequence Detail	3907	Not Applicable
polypeptide	OTTMUSP00000023812	VEGA | MGI Sequence Detail	1170	Not Applicable

All sequences(71) RefSeq(2) UniProt(9)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(345 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020045	5'-3' exonuclease, C-terminal domain
InterPro	IPR006084	DNA repair protein (XPGC)/yeast Rad
InterPro	IPR008918	Helix-hairpin-helix motif, class 2
InterPro	IPR001044	Xeroderma pigmentosum group G protein
InterPro	IPR019974	XPG conserved site
InterPro	IPR006085	XPG N-terminal
InterPro	IPR006086	XPG/RAD2 endonuclease
Protein Ontology	PR:000007167	DNA repair protein complementing XP-G cells

References

(Earliest) J:29500 Shiomi T, et al., An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. Mutat Res. 1994 Mar;314(2):167-75
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)

Other accession IDs

MGD-MRK-24467