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Ercc5
Gene Detail
Symbol

Name
ID
Ercc5
excision repair cross-complementing rodent repair deficiency, complementation group 5
MGI:103582
Synonyms
Xpg
Feature Type
protein coding gene
Genetic Map
Chromosome 1
23.55 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:44147744-44181260 bp, + strand
From VEGA annotation of GRCm38

  33517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ercc5

Human
homologs
Human Homolog ERCC5, excision repair cross-complementation group 5
NCBI Gene ID 2073
neXtProt AC  NX_P28715
Human Synonyms  COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
Human Chr (Location)  13q33; chr13:102845841-102876001 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ERCC5
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display postnatal mortality, severely retarded postnatal growth, impaired small intestine development, reduced organ size, and hypersensitivity to UV irradiation.
 
Human Diseases Modeled Using Mouse Ercc5 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Ercc5 interacts with 86 markers (Mir22, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (28)    Tissues (28)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(1) cDNA(82) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021431 (Evidence)
Ensembl Gene ModelENSMUSG00000026048 (Evidence)
Entrez Gene22592 (Evidence)
UniGene2213
DFCITC1685945, TC1608128, TC1578714
DoTSDT.101315052, DT.101165120, DT.40185643, DT.102556635
NIA Mouse Gene IndexU000231
EC3.1.-.-
Consensus CDS ProjectCCDS35553.1
International Mouse Knockout Project StatusErcc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021431 VEGA Gene Model | MGI Sequence Detail 33517 C57BL/6J ±  kb
transcript OTTMUST00000050813 VEGA | MGI Sequence Detail 3907 Not Applicable 
polypeptide OTTMUSP00000023812 VEGA | MGI Sequence Detail 1170 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(6) UniProt(17)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(491 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020045 5'-3' exonuclease, C-terminal domain
InterPro IPR008918 Helix-hairpin-helix motif, class 2
InterPro IPR019974 XPG conserved site
InterPro IPR006086 XPG-I domain
InterPro IPR006085 XPG N-terminal
InterPro IPR001044 XPG/Rad2 endonuclease, eukaryotes
Protein Ontology PR:000007167 DNA repair protein complementing XP-G cells
References
(Earliest) J:29500 Shiomi T, et al., An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. Mutat Res. 1994 Mar;314(2):167-75
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-24467

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory