About   Help   FAQ
Ercc5 Gene Detail
Summary
  • Symbol
    Ercc5
  • Name
    excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Synonyms
    Xpg
  • Feature Type
    protein coding gene
  • IDs
    MGI:103582
    NCBI Gene: 22592
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:44186904-44220420 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.55 cM, cytoband B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103582
 protein coding gene Chr1:44184084-44220420 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015989
 protein coding gene Chr1:43189072-43223399 (+)
A/J MGP_AJ_G0015973
 protein coding gene Chr1:41848811-41880600 (+)
AKR/J MGP_AKRJ_G0015928
 protein coding gene Chr1:42429686-42462203 (+)
BALB/cJ MGP_BALBcJ_G0015927
 protein coding gene Chr1:41533585-41567523 (+)
C3H/HeJ MGP_C3HHeJ_G0015760
 protein coding gene Chr1:42814638-42851130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016380
 protein coding gene Chr1:44925525-44958762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014102
 protein coding gene Chr1:38684098-38719222 (+)
CAST/EiJ MGP_CASTEiJ_G0015341
 protein coding gene Chr1:42837781-42872643 (+)
CBA/J MGP_CBAJ_G0015732
 protein coding gene Chr1:46232700-46271148 (+)
DBA/2J MGP_DBA2J_G0015833
 protein coding gene Chr1:41155349-41190688 (+)
FVB/NJ MGP_FVBNJ_G0015835
 protein coding gene Chr1:40656703-40687876 (+)
LP/J MGP_LPJ_G0015903
 protein coding gene Chr1:43511177-43547176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015855
 protein coding gene Chr1:48205082-48246189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016427
 protein coding gene Chr1:42650456-42684559 (+)
PWK/PhJ MGP_PWKPhJ_G0015124
 protein coding gene Chr1:41031020-41067510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014906
 protein coding gene Chr1:42675405-42713323 (+)
WSB/EiJ MGP_WSBEiJ_G0015403
 protein coding gene Chr1:42695605-42729221 (+)



Homology
more
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
  • Synonyms
    COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
  • Links
    NCBI Gene ID: 2073
    neXtProt AC: NX_P28715
    UniProt: P28715

  • Chr Location
    13q33.1; chr13:102845831-102875995 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ercc5 mouse models; 8 with human ERCC5 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal mortality, severely retarded postnatal growth, impaired small intestine development, reduced organ size, and hypersensitivity to UV irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    31
  • cDNA Data
    83
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026048 Ensembl Gene Model | MGI Sequence Detail 33517 C57BL/6J ±  kb
    transcript ENSMUST00000027214 Ensembl | MGI Sequence Detail 3907 Not Applicable  
    polypeptide ENSMUSP00000027214 Ensembl | MGI Sequence Detail 1170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 1
      cDNA 83
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24467
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:29500 Shiomi T, et al., An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. Mutat Res. 1994 Mar;314(2):167-75
    • Latest
      J:342658 Gyenis A, et al., Genome-wide RNA polymerase stalling shapes the transcriptome during aging. Nat Genet. 2023 Feb;55(2):268-279
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory