About   Help   FAQ
Ercc5 Gene Detail
Summary
  • Symbol
    Ercc5
  • Name
    excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Synonyms
    Xpg
  • Feature Type
    protein coding gene
  • IDs
    MGI:103582
    NCBI Gene: 22592
  • Gene Overview
    MyGene.info: ERCC5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:44147744-44181260 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.55 cM, cytoband B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103582
protein coding gene Chr1:44146981-44181260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015989
protein coding gene Chr1:43189072-43223399 (+)
A/J MGP_AJ_G0015973
protein coding gene Chr1:41848811-41880600 (+)
AKR/J MGP_AKRJ_G0015928
protein coding gene Chr1:42429686-42462203 (+)
BALB/cJ MGP_BALBcJ_G0015927
protein coding gene Chr1:41533585-41567523 (+)
C3H/HeJ MGP_C3HHeJ_G0015760
protein coding gene Chr1:42814638-42851130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016380
protein coding gene Chr1:44925525-44958762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014102
protein coding gene Chr1:38684098-38719222 (+)
CAST/EiJ MGP_CASTEiJ_G0015341
protein coding gene Chr1:42837781-42872643 (+)
CBA/J MGP_CBAJ_G0015732
protein coding gene Chr1:46232700-46271148 (+)
DBA/2J MGP_DBA2J_G0015833
protein coding gene Chr1:41155349-41190688 (+)
FVB/NJ MGP_FVBNJ_G0015835
protein coding gene Chr1:40656703-40687876 (+)
LP/J MGP_LPJ_G0015903
protein coding gene Chr1:43511177-43547176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015855
protein coding gene Chr1:48205082-48246189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016427
protein coding gene Chr1:42650456-42684559 (+)
PWK/PhJ MGP_PWKPhJ_G0015124
protein coding gene Chr1:41031020-41067510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014906
protein coding gene Chr1:42675405-42713323 (+)
WSB/EiJ MGP_WSBEiJ_G0015403
protein coding gene Chr1:42695605-42729221 (+)



Homology
more
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ERCC5, ERCC excision repair 5, endonuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
  • Links
    NCBI Gene ID: 2073
    neXtProt AC: NX_P28715
    UniProt: P28715

  • Chr Location
    13q33.1; chr13:102845841-102876001 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ercc5 mouse models; 1 with human ERCC5 associations

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal mortality, severely retarded postnatal growth, impaired small intestine development, reduced organ size, and hypersensitivity to UV irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026048 Ensembl Gene Model | MGI Sequence Detail 33517 C57BL/6J ±  kb
    transcript ENSMUST00000027214 Ensembl | MGI Sequence Detail 3907 Not Applicable  
    polypeptide ENSMUSP00000027214 Ensembl | MGI Sequence Detail 1170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 1
      cDNA 83
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24467
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:29500 Shiomi T, et al., An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. Mutat Res. 1994 Mar;314(2):167-75
    • Latest
      J:238129 Treekitkarnmongkol W, et al., Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis. 2016 Dec;37(12):1180-1189

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory