Ercc5^tm2Shm
Targeted Allele Detail

Summary

• Symbol: Ercc5^tm2Shm
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 5; targeted mutation 2, Tadahiro Shiomi
• MGI ID: MGI:3043588
• Synonyms: Xpg-delta-ex15
• Gene: Ercc5 Location: Chr1:44186904-44220420 bp, + strand Genetic Position: Chr1, 23.55 cM, cytoband B
• Alliance: Ercc5^tm2Shm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89911
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 15 was replaced with an MC1-neo cassette via homologous recombination. This C-terminal truncation removed the last 183 amino acids. Northern analysis detected 2 large mRNA's with 6 or 36 amino acids incorporated after exon 14 but lacking exon 15. (J:89911)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc5 Mutation: 53 strains or lines available

References

• Original: J:89911 Shiomi N, et al., Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol Cell Biol. 2004 May;24(9):3712-9
• All: 2 reference(s)