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Cxcr5
Gene Detail
Symbol

Name
ID
Cxcr5
chemokine (C-X-C motif) receptor 5
MGI:103567
Synonyms
Blr1, CXCR-5, Gpcr6
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:44511788-44556391 bp, - strand
From Ensembl annotation of GRCm38

  44604 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CXCR5
Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr5

Human
homologs
CXCR5, chemokine (C-X-C motif) receptor 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 643
neXtProt AC: NX_P32302

Human Synonyms: BLR1, CD185, MDR15

Human Chr (Location): 11q23.3; chr11:118883766-118896271 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(54) Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen.
 
Interactions
Cxcr5 interacts with 188 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process B cell activation, chemotaxis, ...
Component external side of plasma membrane, integral component of membrane, ...
Function chemokine receptor activity, C-X-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (48)    Tissues (34)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RNase protection 5
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CXCR5 ; Xenbase cxcr5    NEW 
Molecular
reagents
All nucleic(18) Genomic(6) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000047880 (Evidence)
Entrez Gene 12145 (Evidence)
DFCI TC1578785, TC1627752
DoTS DT.110599285, DT.60102187
NIA Mouse Gene Index U030780
Consensus CDS Project CCDS23115.1
International Mouse Phenotyping Consortium Status Cxcr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047880 Ensembl Gene Model | MGI Sequence Detail 44604 C57BL/6J ±  kb
transcript ENSMUST00000179828 Ensembl | MGI Sequence Detail 2824 Not Applicable 
polypeptide ENSMUSP00000137518 Ensembl | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001053 CXC chemokine receptor 5
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001209 C-X-C chemokine receptor type 5
References
(Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:214445 Moriyama S, et al., Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30;211(7):1297-305
All references(83)
Other
accession IDs
MGD-MRK-16340, MGD-MRK-24452, MGI:99562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory