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Cxcr5
Gene Detail
Symbol

Name
ID
Cxcr5
chemokine (C-X-C motif) receptor 5
MGI:103567
Synonyms
Blr1, CXCR-5, Gpcr6
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:44511787-44526421 bp, - strand
From NCBI annotation of GRCm38

  14635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr5

Human
homologs
Human Homolog CXCR5, chemokine (C-X-C motif) receptor 5
NCBI Gene ID 643
neXtProt AC  NX_P32302
Human Synonyms  BLR1, CD185, MDR15
Human Chr (Location)  11q23.3; chr11:118883766-118896271 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen.
 
Interactions
Cxcr5 interacts with 189 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process B cell activation, chemotaxis, ...
Component external side of plasma membrane, integral component of membrane, ...
Function chemokine receptor activity, C-X-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (48)    Tissues (34)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RNase protection 5
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(6) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000047880 (Evidence)
Entrez Gene12145 (Evidence)
DFCITC1578785, TC1627752
DoTSDT.110599285, DT.60102187
NIA Mouse Gene IndexU030780
Consensus CDS ProjectCCDS23115.1
International Mouse Knockout Project StatusCxcr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12145 NCBI Gene Model | MGI Sequence Detail 14635 C57BL/6J ±  kb
transcript NM_007551 RefSeq | MGI Sequence Detail 2636 C57BL/6 
polypeptide Q04683 UniProt | EBI | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001053 CXC chemokine receptor 5
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001209 C-X-C chemokine receptor type 5
Graphical View of Protein Domain Structure
References
(Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(81)
Other
accession IDs
MGD-MRK-16340, MGD-MRK-24452, MGI:99562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory