Cxcr5 MGI Mouse Gene Detail - MGI:103567 - C-X-C motif chemokine receptor 5

Symbol

Cxcr5
Name

C-X-C motif chemokine receptor 5
Synonyms

Blr1, CXCR-5, Gpcr6

Feature Type

protein coding gene
IDs

MGI:103567
NCBI Gene: 12145
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:44423084-44437741 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

369 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103567	protein coding gene	Chr9:44423084-44473174 (-)
129S1/SvImJ	ENSMUSG00200018342	protein coding gene	Chr9:41498951-41549643 (-)
A/J	ENSMUSG00195023484	protein coding gene	Chr9:41245600-41302945 (-)
AKR/J	ENSMUSG00220038329	protein coding gene	Chr9:41339830-41389892 (-)
BALB/cJ	ENSMUSG00180025720	protein coding gene	Chr9:41357328-41414678 (-)
C3H/HeJ	ENSMUSG00175014530	protein coding gene	Chr9:41369016-41426361 (-)
C57BL/6NJ	ENSMUSG00215033319	protein coding gene	Chr9:41343354-41393447 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032121	protein coding gene	Chr9:41388298-41428885 (-)
CAST/EiJ	ENSTCUG00005015100	protein coding gene	Chr9:41327404-41379525 (-)
CBA/J	ENSMUSG00210016570	protein coding gene	Chr9:41422861-41472941 (-)
DBA/2J	ENSMUSG00185009133	protein coding gene	Chr9:41483963-41541284 (-)
FVB/NJ	ENSMUSG00205031875	protein coding gene	Chr9:41739281-41789374 (-)
JF1/MsJ	ENSUMUG00000015950	protein coding gene	Chr9:41538595-41589328 (-)
LP/J	no annotation
NOD/ShiLtJ	ENSMUSG00190020820	protein coding gene	Chr9:41562901-41620246 (-)
NZO/HlLtJ	ENSMUSG00225044041	protein coding gene	Chr9:41743741-41801089 (-)
PWK/PhJ	ENSLUMG00010018592	protein coding gene	Chr9:41499087-41549666 (-)
SPRET/EiJ	ENSMSPG00010008840	protein coding gene	Chr9:42261204-42306381 (-)
WSB/EiJ	ENSIUOG00005019175	protein coding gene	Chr9:40976612-41033985 (-)

Human Ortholog

CXCR5, C-X-C motif chemokine receptor 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCR5, C-X-C motif chemokine receptor 5
Synonyms

BLR1, CD185, MDR15
Links

HGNC:1060

NCBI Gene ID: 643

UniProt: P32302
Chr Location

11q23.3; chr11:118883892-118897787 (+) GRCh38

MGI Vertebrate Homology

Cxcr5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CXCR5
Gene Tree

Cxcr5

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
112 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

11
Targeted

7
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

647
Tissues

35
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CXCR5

Xenbase cxcr5

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All Sequences

45
RefSeq

2
UniProt

3
CCDS

CCDS23115.1

Ensembl

ENSMUSG00000047880 (Evidence)
NCBI Gene

12145

			Length	Strain/Species	Flank
genomic	12145	NCBI Gene Model \| MGI Sequence Detail	14658	C57BL/6J	± kb
transcript	NM_007551	RefSeq \| MGI Sequence Detail	2659	ZRU/MplStud
polypeptide	Q04683	UniProt \| EBI \| MGI Sequence Detail	374	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001209 C-X-C chemokine receptor type 5

(term hierarchy)
InterPro Domains

IPR050119 C-C chemokine receptor type 1-9-like

IPR001053 CXC chemokine receptor 5

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q04683 2 sites

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All nucleic 20

Genomic 6

cDNA 11

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-16340, MGD-MRK-24452, MGI:99562

Summaries

All 233

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 112
Earliest

J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
Latest

J:390004 Curtiss ML, et al., CXCR5 Signals Fine-Tune Dendritic Cell Transcription and Regulate T(H)2 Development. Vaccines (Basel). 2025 Sep 3;13(9)

TSS for Cxcr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89171	Chr9:44437801-44437812 (-)	-66 bp
Tssr89170	Chr9:44437766-44437798 (-)	-41 bp
Tssr89169	Chr9:44437721-44437737 (-)	12 bp
Tssr89168	Chr9:44437694-44437720 (-)	34 bp
Tssr89167	Chr9:44437265-44437269 (-)	474 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24