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Cxcr5 Gene Detail
Summary
  • Symbol
    Cxcr5
  • Name
    chemokine (C-X-C motif) receptor 5
  • Synonyms
    Blr1, CXCR-5, Gpcr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:103567
    NCBI Gene: 12145
  • Gene Overview
    MyGene.info: CXCR5
Location & Maps
more
  • Sequence Map
    Chr9:44511787-44526421 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CXCR5, C-X-C motif chemokine receptor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CXCR5, C-X-C motif chemokine receptor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BLR1, CD185, MDR15
  • Links
    NCBI Gene ID: 643
    neXtProt AC: NX_P32302
    UniProt: P32302

  • Chr Location
    11q23.3; chr11:118883766-118896271 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12145 NCBI Gene Model | MGI Sequence Detail 14635 C57BL/6J ±  kb
transcript NM_007551 RefSeq | MGI Sequence Detail 2636 C57BL/6  
polypeptide Q04683 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    Genomic 6
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16340, MGD-MRK-24452, MGI:99562
References
more
  • Summaries
    All 92
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 55
  • Earliest
    J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
  • Latest
    J:238745 Nishikii H, et al., DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease. Blood. 2016 Dec 15;128(24):2846-2858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory