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Kpna2 Gene Detail
Summary
  • Symbol
    Kpna2
  • Name
    karyopherin (importin) alpha 2
  • Synonyms
    2410044B12Rik, Importin alpha, importin alpha 1, m-importin, m-importin-alpha-P1, pendulin, Rch1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103561
    NCBI Gene: 16647
  • Gene Overview
    MyGene.info: KPNA2
Location & Maps
more
  • Sequence Map
    Chr11:106988629-106999541 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10913 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.08 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOA1, QIP2, RCH1, SRP1alpha, SRP1-alpha
  • Links
    NCBI Gene ID: 3838
    neXtProt AC: NX_P52292

  • Chr Location
    17q24.2; chr17:68035732-68046854 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    10
  • Targeted
    1
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    241
  • Tissues
    215
  • cDNA Data
    21
  • Literature Summary
    12
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003580 VEGA Gene Model | MGI Sequence Detail 10913 C57BL/6J ±  kb
transcript OTTMUST00000007708 VEGA | MGI Sequence Detail 2054 Not Applicable  
polypeptide OTTMUSP00000003739 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009433 importin subunit alpha-2
Molecular
Reagents
less
  • All nucleic 27
    cDNA 22
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-24446, MGI:1913724
References
more
  • Summaries
    All 66
    Developmental Gene Expression 12
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
  • Latest
    J:228044 Mihalas BP, et al., Changing expression and subcellular distribution of karyopherins during murine oogenesis. Reproduction. 2015 Dec;150(6):485-96
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory