Kpna2 MGI Mouse Gene Detail - MGI:103561 - karyopherin (importin) alpha 2

Symbol

Kpna2
Name

karyopherin (importin) alpha 2
Synonyms

2410044B12Rik, Importin alpha, importin alpha 1, m-importin, m-importin-alpha-P1, pendulin, Rch1

Feature Type

protein coding gene
IDs

MGI:103561
NCBI Gene: 16647
Gene Overview

MyGene.info: KPNA2
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:106988629-106999525 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.08 cM
Mapping Data

4 experiments

SNPs within 2kb

64 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103561	protein coding gene	Chr11:106988629-106999541 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019316	protein coding gene	Chr11:110336239-110351582 (-)
A/J	MGP_AJ_G0019284	protein coding gene	Chr11:105620089-105633102 (-)
AKR/J	MGP_AKRJ_G0019253	protein coding gene	Chr11:108763592-108775364 (-)
BALB/cJ	MGP_BALBcJ_G0019258	protein coding gene	Chr11:106032592-106045239 (-)
C3H/HeJ	MGP_C3HHeJ_G0019067	protein coding gene	Chr11:109063687-109074762 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019708	protein coding gene	Chr11:113746938-113763712 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017332	protein coding gene	Chr11:102889255-102900278 (-)
CAST/EiJ	MGP_CASTEiJ_G0018620	protein coding gene	Chr11:110160870-110172377 (-)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0019148	protein coding gene	Chr11:105094034-105109014 (-)
FVB/NJ	MGP_FVBNJ_G0019139	protein coding gene	Chr11:104600981-104612169 (-)
LP/J	MGP_LPJ_G0019218	protein coding gene	Chr11:110794425-110802628 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019169	protein coding gene	Chr11:117677798-117691269 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019745	protein coding gene	Chr11:109286320-109301627 (-)
PWK/PhJ	MGP_PWKPhJ_G0018385	protein coding gene	Chr11:106208397-106220154 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018176	protein coding gene	Chr11:109059595-109077033 (-)
WSB/EiJ	MGP_WSBEiJ_G0018671	protein coding gene	Chr11:109257686-109270605 (-)

Human Ortholog

KPNA2, karyopherin subunit alpha 2

Vertebrate Orthologs

11

Human Ortholog

KPNA2, karyopherin subunit alpha 2
Orthology source: HomoloGene, HGNC
Synonyms

IPOA1, QIP2, RCH1, SRP1alpha, SRP1-alpha
Links

HGNC:6395

NCBI Gene ID: 3838

neXtProt AC: NX_P52292

UniProt: P52292
Chr Location

17q24.2; chr17:68035602-68046859 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1708
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KPNA2
Protein SuperFamily

Importin_alpha
Gene Tree

Kpna2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

10
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

240
Tissues

214
cDNA Data

23
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kpna2

ZFIN kpna2

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Kpna2 interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

57
RefSeq

2
UniProt

1
CCDS

CCDS25565.1

Ensembl

ENSMUSG00000018362 (Evidence)
NCBI Gene

16647

			Length	Strain/Species	Flank
genomic	16647	NCBI Gene Model \| MGI Sequence Detail	10897	C57BL/6J	± kb
transcript	NM_010655	RefSeq \| MGI Sequence Detail	2071	Not Specified
polypeptide	P52293	UniProt \| EBI \| MGI Sequence Detail	529	Not Applicable

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UniProt

1 Sequence

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All nucleic 30

cDNA 24

Primer pair 4

Other 2

Microarray probesets 5

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MGD-MRK-24446, MGI:1913724

Summaries

All 77

Developmental Gene Expression 13

Gene Ontology 13

Phenotypes 9
Earliest

J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
Latest

J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

TSS for Kpna2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111433	Chr11:106999482-106999503 (-)	32 bp
Tssr111432	Chr11:106999461-106999473 (-)	58 bp
Tssr111431	Chr11:106998483-106998491 (-)	1,038 bp
Tssr111430	Chr11:106998465-106998482 (-)	1,051 bp
Tssr111429	Chr11:106998449-106998463 (-)	1,069 bp
Tssr111428	Chr11:106998441-106998446 (-)	1,081 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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