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Kpna2 Gene Detail
Summary
  • Symbol
    Kpna2
  • Name
    karyopherin (importin) alpha 2
  • Synonyms
    2410044B12Rik, Importin alpha, importin alpha 1, m-importin, m-importin-alpha-P1, pendulin, Rch1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103561
    NCBI Gene: 16647
  • Gene Overview
    MyGene.info: KPNA2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106988629-106999525 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 70.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103561
protein coding gene Chr11:106988629-106999541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019316
protein coding gene Chr11:110336239-110351582 (-)
A/J MGP_AJ_G0019284
protein coding gene Chr11:105620089-105633102 (-)
AKR/J MGP_AKRJ_G0019253
protein coding gene Chr11:108763592-108775364 (-)
BALB/cJ MGP_BALBcJ_G0019258
protein coding gene Chr11:106032592-106045239 (-)
C3H/HeJ MGP_C3HHeJ_G0019067
protein coding gene Chr11:109063687-109074762 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019708
protein coding gene Chr11:113746938-113763712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017332
protein coding gene Chr11:102889255-102900278 (-)
CAST/EiJ MGP_CASTEiJ_G0018620
protein coding gene Chr11:110160870-110172377 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019148
protein coding gene Chr11:105094034-105109014 (-)
FVB/NJ MGP_FVBNJ_G0019139
protein coding gene Chr11:104600981-104612169 (-)
LP/J MGP_LPJ_G0019218
protein coding gene Chr11:110794425-110802628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019169
protein coding gene Chr11:117677798-117691269 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019745
protein coding gene Chr11:109286320-109301627 (-)
PWK/PhJ MGP_PWKPhJ_G0018385
protein coding gene Chr11:106208397-106220154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018176
protein coding gene Chr11:109059595-109077033 (-)
WSB/EiJ MGP_WSBEiJ_G0018671
protein coding gene Chr11:109257686-109270605 (-)



Homology
more
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOA1, QIP2, RCH1, SRP1alpha, SRP1-alpha
  • Links
    NCBI Gene ID: 3838
    neXtProt AC: NX_P52292
    UniProt: P52292

  • Chr Location
    17q24.2; chr17:68035602-68046859 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16647 NCBI Gene Model | MGI Sequence Detail 10897 C57BL/6J ±  kb
transcript NM_010655 RefSeq | MGI Sequence Detail 2071 Not Specified  
polypeptide P52293 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 30
    cDNA 24
    Primer pair 4
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-24446, MGI:1913724
References
more
  • Summaries
    All 76
    Developmental Gene Expression 13
    Gene Ontology 13
    Phenotypes 8
  • Earliest
    J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
  • Latest
    J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory