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Kpna2 Gene Detail
Summary
  • Symbol
    Kpna2
  • Name
    karyopherin (importin) alpha 2
  • Synonyms
    2410044B12Rik, Importin alpha, importin alpha 1, m-importin, m-importin-alpha-P1, pendulin, Rch1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103561
    NCBI Gene: 16647
  • Gene Overview
    MyGene.info: KPNA2
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106988629-106999525 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103561
 protein coding gene Chr11:106988629-106999541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019316
 protein coding gene Chr11:110336239-110351582 (-)
A/J MGP_AJ_G0019284
 protein coding gene Chr11:105620089-105633102 (-)
AKR/J MGP_AKRJ_G0019253
 protein coding gene Chr11:108763592-108775364 (-)
BALB/cJ MGP_BALBcJ_G0019258
 protein coding gene Chr11:106032592-106045239 (-)
C3H/HeJ MGP_C3HHeJ_G0019067
 protein coding gene Chr11:109063687-109074762 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019708
 protein coding gene Chr11:113746938-113763712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017332
 protein coding gene Chr11:102889255-102900278 (-)
CAST/EiJ MGP_CASTEiJ_G0018620
 protein coding gene Chr11:110160870-110172377 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019148
 protein coding gene Chr11:105094034-105109014 (-)
FVB/NJ MGP_FVBNJ_G0019139
 protein coding gene Chr11:104600981-104612169 (-)
LP/J MGP_LPJ_G0019218
 protein coding gene Chr11:110794425-110802628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019169
 protein coding gene Chr11:117677798-117691269 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019745
 protein coding gene Chr11:109286320-109301627 (-)
PWK/PhJ MGP_PWKPhJ_G0018385
 protein coding gene Chr11:106208397-106220154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018176
 protein coding gene Chr11:109059595-109077033 (-)
WSB/EiJ MGP_WSBEiJ_G0018671
 protein coding gene Chr11:109257686-109270605 (-)



Homology
more
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOA1, QIP2, RCH1, SRP1alpha, SRP1-alpha
  • Links
    NCBI Gene ID: 3838
    neXtProt AC: NX_P52292
    UniProt: P52292

  • Chr Location
    17q24.2; chr17:68035602-68046859 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    214
  • cDNA Data
    23
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16647 NCBI Gene Model | MGI Sequence Detail 10897 C57BL/6J ±  kb
    transcript NM_010655 RefSeq | MGI Sequence Detail 2071 Not Specified  
    polypeptide P52293 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 24
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24446, MGI:1913724
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 9
    • Earliest
      J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
    • Latest
      J:289863 Cai Z, et al., USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J Exp Med. 2020 May 4;217(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory