Sequence Detail

ID/Version

P52293 Q64292 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Importin subunit alpha-1 {ECO:0000305};AltName: Full=Importin alpha P1;AltName: Full=Karyopherin subunit alpha-2;AltName: Full=Pendulin;AltName: Full=Pore targeting complex 58 kDa subunit; Short=PTAC58;AltName: Full=RAG cohort protei

Provider

SWISS-PROT

Sequence

Polypeptide 529 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kpna2	karyopherin subunit alpha 2	46	113	4	17

Sequence references in MGI

J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
J:30192 Kussel P, et al., Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis. Mol Gen Genet. 1995 Aug 21;248(3):351-63
J:36265 Prieve MG, et al., The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. J Biol Chem. 1996 Mar 29;271(13):7654-8
J:103359 Matsuura Y, et al., Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. EMBO J. 2005 Nov 2;24(21):3681-9
J:225415 Fontes MR, et al., Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. J Mol Biol. 2000 Apr 14;297(5):1183-94
J:281212 Miriyala S, et al., Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. Free Radic Biol Med. 2016 Feb;91:68-80
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89