Sox18
Gene Detail

Symbol Name ID

Sox18 SRY-box containing gene 18 MGI:103559

Synonyms

Ragl, Sry-related HMG-box gene 18

Feature Type

protein coding gene

Genetic Map

Chromosome 2

103.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(47)

Sequence Map

Chr2:181669836-181671640 bp, - strand From VEGA annotation of GRCm38   1805 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox18

Human homologs

Human Homolog		SOX18, SRY (sex determining region Y)-box 18
NCBI Gene ID		54345
neXtProt AC		NX_P35713
Human Synonyms		HLTS
Human Chr (Location)		20q13.33; chr20:62679079-62680979 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SOX18

Alleles and phenotypes

All alleles(8) : Targeted(3) Spontaneous(4) Chemically induced(1)
 

Homozygotes for some mutant alleles show low prenatal viability and cardiovascular defects. Most mutants show darkened coats, reduced zigzag hairs and, depending on the allele, sparse abnormal hair and edema. Heterozygotes show similar or milder defects.

 
Human Diseases Modeled Using Mouse Sox18 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	angiogenesis, blood vessel development, ...
Component	nuclear chromatin, nucleus
Function	DNA binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (222)    Tissues (212)    Images (13)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	219
RT-PCR	3

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016810 (Evidence)
Ensembl Gene Model	ENSMUSG00000046470 (Evidence)
Entrez Gene	20672 (Evidence)
UniGene	264904
DFCI	TC1581181
DoTS	DT.529466, DT.94145980, DT.94145993
NIA Mouse Gene Index	U023794
Consensus CDS Project	CCDS17218.1
International Mouse Knockout Project Status	Sox18

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016810	VEGA Gene Model | MGI Sequence Detail	1805	C57BL/6J
transcript	OTTMUST00000040830	VEGA | MGI Sequence Detail	1620	Not Applicable
polypeptide	OTTMUSP00000018259	VEGA | MGI Sequence Detail	377	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group (HMG) box domain
InterPro	IPR021934	Sox C-terminal transactivation domain
Protein Ontology	PR:000015425	transcription factor SOX-18

References

(Earliest) J:86 Carter TC, et al., Ragged, a semidominant coat texture mutant. J Hered. 1954;45:151-154
(Latest) J:191641 Oommen S, et al., Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS One. 2012;7(9):e43857
All references(102)

Other accession IDs

MGD-MRK-13743, MGD-MRK-24444, MGI:1336180, MGI:2138921, MGI:97841