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Apobec1
Gene Detail
Symbol

Name
ID
Apobec1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
MGI:103298
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:122577792-122602444 bp, - strand
From VEGA annotation of GRCm38

  24653 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: APOBEC1
Protein SuperFamily: apolipoprotein B mRNA editing enzyme, catalytic chain 1
Gene Tree: Apobec1

Human
homologs
APOBEC1, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 339
neXtProt AC: NX_P41238

Human Synonyms: APOBEC-1, BEDP, CDAR1, HEPR

Human Chr (Location): 12p13.1; chr12:7649400-7670599 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal lipid homeostasis.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Apobec1 interacts with 150 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (11)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 11
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(4) cDNA(54) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024356 (Evidence)
Ensembl Gene Model ENSMUSG00000040613 (Evidence)
Entrez Gene 11810 (Evidence)
UniGene 3333
DFCI TC1580798, TC1593206, TC1594740
DoTS DT.491305, DT.101377453, DT.91339447
NIA Mouse Gene Index U027825
EC 3.5.4.-
Consensus CDS Project CCDS20498.1
International Mouse Phenotyping Consortium Status Apobec1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024356 VEGA Gene Model | MGI Sequence Detail 24653 C57BL/6J ±  kb
transcript OTTMUST00000059665 VEGA | MGI Sequence Detail 2265 Not Applicable 
polypeptide OTTMUSP00000029041 VEGA | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016192 APOBEC/CMP deaminase, zinc-binding
InterPro IPR007904 APOBEC-like, C-terminal
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000004147 C->U-editing enzyme APOBEC-1
References
(Earliest) J:25752 Nakamuta M, et al., Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases. J Biol Chem. 1995 Jun 2;270(22):13042-56
(Latest) J:217130 Fossat N, et al., C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO Rep. 2014 Aug;15(8):903-10
All references(91)
Other
accession IDs
MGD-MRK-24181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory