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Apobec1
Gene Detail
 Symbol
Name
ID
Apobec1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
MGI:103298
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:122577792-122602444 bp, - strand
From VEGA annotation of GRCm38

  24653 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: apolipoprotein B mRNA editing enzyme, catalytic chain 1
Gene Tree: Apobec1

Human
homologs
Human Homolog APOBEC1, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
NCBI Gene ID 339
neXtProt AC  NX_P41238
Human Synonyms  APOBEC-1, BEDP, CDAR1, HEPR
Human Chr (Location)  12p13.1; chr12:7649400-7670599 (-)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Targeted(4) Gene trapped(9)
 
Mice homozygous for a null allele exhibit abnormal lipid homeostasis.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cytidine deamination, cytidine to uridine editing, ...
Component cytoplasm, nucleus
Function AU-rich element binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (3)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 11
cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(59) Genomic(4) cDNA(54) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024356 (Evidence)
Ensembl Gene ModelENSMUSG00000040613 (Evidence)
Entrez Gene11810 (Evidence)
UniGene3333
DFCITC1580798, TC1593206, TC1594740
DoTSDT.101377453, DT.491305, DT.91339447
NIA Mouse Gene IndexU027825
EC3.5.4.-
Consensus CDS ProjectCCDS20498.1
International Mouse Knockout Project StatusApobec1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024356 VEGA Gene Model | MGI Sequence Detail 24653 C57BL/6J ±  kb
transcript OTTMUST00000059665 VEGA | MGI Sequence Detail 2265 Not Applicable 
polypeptide OTTMUSP00000029041 VEGA | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016192 APOBEC/CMP deaminase, zinc-binding
InterPro IPR007904 APOBEC-like, C-terminal
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000004147 C->U-editing enzyme APOBEC-1
References (Earliest) J:25752 Nakamuta M, et al., Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases. J Biol Chem. 1995 Jun 2;270(22):13042-56
(Latest) J:204609 Pinkaew D, et al., Fortilin reduces apoptosis in macrophages and promotes atherosclerosis. Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1519-29
All references(89)
Other
accession IDs
MGD-MRK-24181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory