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Apobec1 Gene Detail
Summary
  • Symbol
    Apobec1
  • Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103298
    NCBI Gene: 11810
  • Gene Overview
    MyGene.info: APOBEC1
Location & Maps
more
  • Sequence Map
    Chr6:122577792-122602444 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24653 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.68 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    APOBEC1, apolipoprotein B mRNA editing enzyme catalytic subunit 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APOBEC1, apolipoprotein B mRNA editing enzyme catalytic subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APOBEC-1, BEDP, CDAR1, HEPR
  • Links
    NCBI Gene ID: 339
    neXtProt AC: NX_P41238

  • Chr Location
    12p13.1; chr12:7649400-7670599 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    9
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal lipid homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024356 VEGA Gene Model | MGI Sequence Detail 24653 C57BL/6J ±  kb
transcript OTTMUST00000059665 VEGA | MGI Sequence Detail 2265 Not Applicable  
polypeptide OTTMUSP00000029041 VEGA | MGI Sequence Detail 229 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    167 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004147 C->U-editing enzyme APOBEC-1
  • EC
  • InterPro Domains
    IPR016192 APOBEC/CMP deaminase, zinc-binding
    IPR013158 APOBEC-like, N-terminal
    IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding
    IPR016193 Cytidine deaminase-like
Molecular
Reagents
less
  • All nucleic 59
    Genomic 4
    cDNA 54
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-24181
References
more
  • Summaries
    All 90
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 12
    Phenotypes 42
  • Earliest
    J:25752 Nakamuta M, et al., Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases. J Biol Chem. 1995 Jun 2;270(22):13042-56
  • Latest
    J:229082 Smallwood TL, et al., High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis. G3 (Bethesda). 2014 Dec;4(12):2353-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory