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Ptpn13
Gene Detail
Symbol

Name
ID
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
MGI:103293
Synonyms
PTP-BL, PTPL1, Ptpri
Feature Type
protein coding gene
Genetic Map
Chromosome 5
50.43 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:103425192-103598359 bp, + strand
From Ensembl annotation of GRCm38

  173168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7909  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, type 13
Gene Tree: Ptpn13

Human
homologs
Human Homolog PTPN13, protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
NCBI Gene ID 5783
neXtProt AC  NX_Q12923
Human Synonyms  FAP-1, hPTP1E, PNP1, PTP1E, PTP-BAS, PTP-BL, PTPL1, PTPLE
Human Chr (Location)  4q21.3; chr4:86594315-86815179 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal T-helper cell differentiation.
 
Interactions
Ptpn13 interacts with 201 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process dephosphorylation, peptidyl-tyrosine dephosphorylation, ...
Component cell body, cell projection, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (13)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 9
RT-PCR 2
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(3) cDNA(118) Primer pair(1) Other(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000034573 (Evidence)
Entrez Gene19249 (Evidence)
UniGene3414
DFCITC1617546, TC1605352, TC1600594, TC1576755
DoTSDT.101736292, DT.101382079, DT.94159971, DT.91589660, DT.110655742, DT.97413329
NIA Mouse Gene IndexU005882
EC3.1.3.48
PDB1OZI, 1VJ6, 1GM1
Consensus CDS ProjectCCDS39186.1
International Mouse Knockout Project StatusPtpn13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034573 Ensembl Gene Model | MGI Sequence Detail 173168 C57BL/6J ±  kb
transcript ENSMUST00000048957 Ensembl | MGI Sequence Detail 8280 Not Applicable 
polypeptide ENSMUSP00000048119 Ensembl | MGI Sequence Detail 2451 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(16) UniProt(17)
Polymorphisms
RFLP(1) : SNPs within 2kb(1104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR011019 KIND
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR012153 Protein-tyrosine phosphatase, non-receptor type-13
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013451 tyrosine-protein phosphatase non-receptor type 13
References
(Earliest) J:22419 Hendriks W, et al., A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305(Pt 2):499-504
(Latest) J:193567 Abaan OD, et al., Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1. Exp Cell Res. 2013 Jan 1;319(1):1-11
All references(45)
Other
accession IDs
MGD-MRK-24175, MGD-MRK-24182, MGI:2140837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory