Mcf2l
Gene Detail

Symbol Name ID

Mcf2l mcf.2 transforming sequence-like MGI:103263

Synonyms

C130040G20Rik, Dbs, mKIAA0362

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:12873806-13020905 bp, + strand From VEGA annotation of GRCm38   147100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dbl transforming protein
Gene Tree: Mcf2l

Human homologs

Human Homolog		MCF2L, MCF.2 cell line derived transforming sequence-like
NCBI Gene ID		23263
neXtProt AC		NX_O15068
Human Synonyms		ARHGEF14, DBS, OST
Human Chr (Location)		13q34; chr13:112894378-113099739 (+)  GRCh38

Alleles and phenotypes

All alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	intracellular signal transduction, positive regulation of Rho GTPase activity, ...
Component	cytoplasm, extracellular space, ...
Function	1-phosphatidylinositol binding, guanyl-nucleotide exchange factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (25)    Tissues (18)    Images (15)
Theiler Stages: 21, 22, 24, 25, 26, 28

Assay Type	Results
RNA in situ	19
Northern blot	6

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(137) Genomic(1) cDNA(136)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020608 (Evidence)
Ensembl Gene Model	ENSMUSG00000031442 (Evidence)
Entrez Gene	17207 (Evidence)
UniGene	334413
DFCI	TC1574408, TC1594206, TC1604419, TC1609018, TC1609157, TC1617336, TC1695881
DoTS	DT.101217837, DT.101386398, DT.101386401, DT.101737809, DT.101737810, DT.110900679, DT.530388, DT.55244243, DT.94162731
NIA Mouse Gene Index	U009095
PDB	1KZG, 1KZ7, 1LB1, 1RJ2
Consensus CDS Project	CCDS40225.2, CCDS52482.1, CCDS52483.1
International Mouse Knockout Project Status	Mcf2l

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020608	VEGA Gene Model | MGI Sequence Detail	147100	C57BL/6J
transcript	OTTMUST00000048821	VEGA | MGI Sequence Detail	5253	Not Applicable
polypeptide	OTTMUSP00000022488	VEGA | MGI Sequence Detail	1175	Not Applicable

All sequences(191) RefSeq(46) UniProt(24)

Polymorphisms

SNPs within 2kb(1762 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001251	CRAL-TRIO domain
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000010238	guanine nucleotide exchange factor DBS

References

(Earliest) J:23628 Whitehead I, et al., Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene. 1995 Feb 16;10(4):713-21
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(48)

Other accession IDs

MGD-MRK-24142, MGI:2442384