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Mcf2l
Gene Detail
Symbol

Name
ID
Mcf2l
mcf.2 transforming sequence-like
MGI:103263
Synonyms
C130040G20Rik, Dbs, mKIAA0362
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:12873806-13020905 bp, + strand
From VEGA annotation of GRCm38

  147100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dbl transforming protein
Gene Tree: Mcf2l

Human
homologs
Human Homolog MCF2L, MCF.2 cell line derived transforming sequence-like
NCBI Gene ID 23263
neXtProt AC  NX_O15068
Human Synonyms  ARHGEF14, DBS, OST
Human Chr (Location)  13q34; chr13:112894378-113099739 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mcf2l interacts with 348 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (21)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 6
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(137) Genomic(1) cDNA(136)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020608 (Evidence)
Ensembl Gene ModelENSMUSG00000031442 (Evidence)
Entrez Gene17207 (Evidence)
UniGene334413
DFCITC1574408, TC1594206, TC1609018, TC1604419, TC1609157, TC1695881, TC1617336
DoTSDT.94162731, DT.101217837, DT.55244243, DT.101386398, DT.530388, DT.110900679, DT.101386401, DT.101737810, DT.101737809
NIA Mouse Gene IndexU009095
PDB1KZG, 1RJ2, 1LB1, 1KZ7
Consensus CDS ProjectCCDS40225.2, CCDS52482.1, CCDS52483.1
International Mouse Knockout Project StatusMcf2l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020608 VEGA Gene Model | MGI Sequence Detail 147100 C57BL/6J ±  kb
transcript OTTMUST00000048821 VEGA | MGI Sequence Detail 5253 Not Applicable 
polypeptide OTTMUSP00000022488 VEGA | MGI Sequence Detail 1175 Not Applicable 

For the selected sequences
All sequences(214) RefSeq(46) UniProt(47)
Polymorphisms
SNPs within 2kb(1762 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000010238 guanine nucleotide exchange factor DBS
References
(Earliest) J:23628 Whitehead I, et al., Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene. 1995 Feb 16;10(4):713-21
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(48)
Other
accession IDs
MGD-MRK-24142, MGI:2442384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory