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Mcf2l Gene Detail
Summary
  • Symbol
    Mcf2l
  • Name
    mcf.2 transforming sequence-like
  • Synonyms
    C130040G20Rik, Dbs, mKIAA0362
  • Feature Type
    protein coding gene
  • IDs
    MGI:103263
    NCBI Gene: 17207
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:12923806-13070502 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103263
 protein coding gene Chr8:12923806-13070905 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033367
 protein coding gene Chr8:10181391-10333479 (+)
A/J MGP_AJ_G0033347
 protein coding gene Chr8:9818588-9966344 (+)
AKR/J MGP_AKRJ_G0033278
 protein coding gene Chr8:10082220-10231796 (+)
BALB/cJ MGP_BALBcJ_G0033348
 protein coding gene Chr8:9958841-10106744 (+)
C3H/HeJ MGP_C3HHeJ_G0033061
 protein coding gene Chr8:10291678-10443525 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033860
 protein coding gene Chr8:10550746-10700398 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030829
 protein coding gene Chr8:9324261-9473508 (+)
CAST/EiJ MGP_CASTEiJ_G0032383
 protein coding gene Chr8:10059205-10205219 (+)
CBA/J MGP_CBAJ_G0033034
 protein coding gene Chr8:11000721-11151281 (+)
DBA/2J MGP_DBA2J_G0033187
 protein coding gene Chr8:9778472-9925172 (+)
FVB/NJ MGP_FVBNJ_G0033136
 protein coding gene Chr8:9779051-9929978 (+)
LP/J MGP_LPJ_G0033281
 protein coding gene Chr8:10103147-10256352 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033170
 protein coding gene Chr8:11255051-11407958 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033877
 protein coding gene Chr8:10143661-10295856 (+)
PWK/PhJ MGP_PWKPhJ_G0032096
 protein coding gene Chr8:9820248-9969865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031938
 protein coding gene Chr8:10031702-10184557 (+)
WSB/EiJ MGP_WSBEiJ_G0032499
 protein coding gene Chr8:10176639-10330772 (+)



Homology
more
  • Human Ortholog
    MCF2L, MCF.2 cell line derived transforming sequence like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCF2L, MCF.2 cell line derived transforming sequence like
  • Synonyms
    ARHGEF14, DBS, OST
  • Links
    NCBI Gene ID: 23263
    UniProt: O15068

  • Chr Location
    13q34; chr13:112894335-113099742 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    24
  • cDNA Data
    135
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17207 NCBI Gene Model | MGI Sequence Detail 146697 C57BL/6J ±  kb
    transcript NM_001371043 RefSeq | MGI Sequence Detail 5396 C57BL/6  
    polypeptide Q64096 UniProt | EBI | MGI Sequence Detail 1149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 2
      cDNA 136
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24142, MGI:2442384
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:23628 Whitehead I, et al., Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene. 1995 Feb 16;10(4):713-21
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory