Mcf2l MGI Mouse Gene Detail - MGI:103263 - mcf.2 transforming sequence-like

Symbol

Mcf2l
Name

mcf.2 transforming sequence-like
Synonyms

C130040G20Rik, Dbs, mKIAA0362

Feature Type

protein coding gene
IDs

MGI:103263
NCBI Gene: 17207
Gene Overview

MyGene.info: MCF2L
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr8:12873544-13020509 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

1758 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103263	protein coding gene	Chr8:12873544-13020905 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033367	protein coding gene	Chr8:10181391-10333479 (+)
A/J	MGP_AJ_G0033347	protein coding gene	Chr8:9818588-9966344 (+)
AKR/J	MGP_AKRJ_G0033278	protein coding gene	Chr8:10082220-10231796 (+)
BALB/cJ	MGP_BALBcJ_G0033348	protein coding gene	Chr8:9958841-10106744 (+)
C3H/HeJ	MGP_C3HHeJ_G0033061	protein coding gene	Chr8:10291678-10443525 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033860	protein coding gene	Chr8:10550746-10700398 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030829	protein coding gene	Chr8:9324261-9473508 (+)
CAST/EiJ	MGP_CASTEiJ_G0032383	protein coding gene	Chr8:10059205-10205219 (+)
CBA/J	MGP_CBAJ_G0033034	protein coding gene	Chr8:11000721-11151281 (+)
DBA/2J	MGP_DBA2J_G0033187	protein coding gene	Chr8:9778472-9925172 (+)
FVB/NJ	MGP_FVBNJ_G0033136	protein coding gene	Chr8:9779051-9929978 (+)
LP/J	MGP_LPJ_G0033281	protein coding gene	Chr8:10103147-10256352 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033170	protein coding gene	Chr8:11255051-11407958 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033877	protein coding gene	Chr8:10143661-10295856 (+)
PWK/PhJ	MGP_PWKPhJ_G0032096	protein coding gene	Chr8:9820248-9969865 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031938	protein coding gene	Chr8:10031702-10184557 (+)
WSB/EiJ	MGP_WSBEiJ_G0032499	protein coding gene	Chr8:10176639-10330772 (+)

Human Ortholog

MCF2L, MCF.2 cell line derived transforming sequence like

Vertebrate Orthologs

10

Human Ortholog

MCF2L, MCF.2 cell line derived transforming sequence like
Orthology source: HomoloGene, HGNC
Synonyms

ARHGEF14, DBS, OST
Links

HGNC:14576

NCBI Gene ID: 23263

neXtProt AC: NX_O15068

UniProt: O15068
Chr Location

13q34; chr13:112894378-113099739 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11804
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MCF2L
Protein SuperFamily

dbl transforming protein
Gene Tree

Mcf2l

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Gene trapped

18
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

27
Tissues

22
cDNA Data

135
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MCF2L

Xenbase mcf2l, mcf2l.2

ZFIN mcf2la

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Mcf2l interacts with 347 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

130
RefSeq

22
UniProt

24
CCDS

CCDS40225.2, CCDS52482.1, CCDS52483.1
UniGene

334413

Ensembl

ENSMUSG00000031442 (Evidence)
NCBI Gene

17207

			Length	Strain/Species	Flank
genomic	17207	NCBI Gene Model \| MGI Sequence Detail	146966	C57BL/6J	± kb
transcript	NM_001371043	RefSeq \| MGI Sequence Detail	5396	C57BL/6
polypeptide	Q64096	UniProt \| EBI \| MGI Sequence Detail	1149	Not Applicable

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UniProt

24 Sequences
Protein Ontology

PR:000010238 guanine nucleotide exchange factor DBS

(term hierarchy)
PDB

1KZ7, 1KZG, 1LB1, 1RJ2
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR035534 DBS, PH domain

IPR035532 DBS, SH3 domain

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR018159 Spectrin/alpha-actinin

IPR002017 Spectrin repeat

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All nucleic 139

Genomic 2

cDNA 136

Primer pair 1

Microarray probesets 3

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MGD-MRK-24142, MGI:2442384

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 9
Earliest

J:23628 Whitehead I, et al., Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene. 1995 Feb 16;10(4):713-21
Latest

J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966

TSS for Mcf2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76297	Chr8:12873793-12873826 (+)	266 bp
Tssr76298	Chr8:12873902-12873929 (+)	372 bp
Tssr76299	Chr8:12915677-12915690 (+)	42,140 bp
Tssr76300	Chr8:12915879-12915966 (+)	42,379 bp
Tssr76301	Chr8:12926192-12926201 (+)	52,653 bp
Tssr76302	Chr8:12926204-12926218 (+)	52,667 bp
Tssr76303	Chr8:12926268-12926291 (+)	52,736 bp
Tssr76304	Chr8:12926299-12926317 (+)	52,764 bp
Tssr76308	Chr8:12947865-12947931 (+)	74,354 bp
Tssr76310	Chr8:12947965-12947976 (+)	74,427 bp
Tssr76311	Chr8:12947981-12948010 (+)	74,452 bp
Tssr76312	Chr8:12949372-12949383 (+)	75,834 bp
Tssr76313	Chr8:12949416-12949428 (+)	75,878 bp
Tssr76314	Chr8:12949430-12949469 (+)	75,906 bp
Tssr76315	Chr8:12949480-12949491 (+)	75,942 bp
Tssr76316	Chr8:12949494-12949510 (+)	75,958 bp
Tssr76317	Chr8:12949512-12949533 (+)	75,979 bp
Tssr76319	Chr8:12984246-12984330 (+)	110,744 bp
Tssr76320	Chr8:12984370-12984379 (+)	110,831 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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