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Mcf2l Gene Detail
Summary
  • Symbol
    Mcf2l
  • Name
    mcf.2 transforming sequence-like
  • Synonyms
    C130040G20Rik, Dbs, mKIAA0362
  • Feature Type
    protein coding gene
  • IDs
    MGI:103263
    NCBI Gene: 17207
  • Gene Overview
    MyGene.info: MCF2L
Location & Maps
more
  • Sequence Map
    Chr8:12873806-13020905 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      147100 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MCF2L, MCF.2 cell line derived transforming sequence like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCF2L, MCF.2 cell line derived transforming sequence like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGEF14, DBS, OST
  • Links
    NCBI Gene ID: 23263
    neXtProt AC: NX_O15068

  • Chr Location
    13q34; chr13:112894378-113099739 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    18
  • Targeted
    1
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    27
  • Tissues
    22
  • cDNA Data
    135
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020608 VEGA Gene Model | MGI Sequence Detail 147100 C57BL/6J ±  kb
transcript OTTMUST00000048821 VEGA | MGI Sequence Detail 5253 Not Applicable  
polypeptide OTTMUSP00000022488 VEGA | MGI Sequence Detail 1175 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1758 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 138
    Genomic 1
    cDNA 136
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-24142, MGI:2442384
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:23628 Whitehead I, et al., Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene. 1995 Feb 16;10(4):713-21
  • Latest
    J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory