About   Help   FAQ
Phc1
Gene Detail
Symbol

Name
ID
Phc1
polyhomeotic-like 1 (Drosophila)
MGI:103248
Synonyms
Edr1, Mph1, rae28, Rae-28
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.52 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:122317738-122340506 bp, - strand
From VEGA annotation of GRCm38

  22769 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:107079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PHC1
Gene Tree: Phc1

Human
homologs
PHC1, polyhomeotic homolog 1 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1911
neXtProt AC: NX_P78364

Human Synonyms: EDR1, HPH1, MCPH11, RAE28

Human Chr (Location): 12p13; chr12:8914684-8941467 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PHC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(175) : Gene trapped(170) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit perinatal lethality, posterior skeletal transformations and defects in neural crest derived tissues, including ocular abnormalities, cleft palate, parathyroid and thymic hypoplasia and cardiac anomalies. Hematopoiesis is impaired in fetal livers.
 
Human Diseases Modeled in Mice Using Phc1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Phc1 interacts with 361 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to retinoic acid, histone ubiquitination, ...
Component nuclear body, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (323)    Tissues (243)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 228
Northern blot 21
Western blot 29
RT-PCR 45
cDNA source data(174)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(183) Genomic(4) cDNA(175) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034663 (Evidence)
Ensembl Gene Model ENSMUSG00000040669 (Evidence)
Entrez Gene 13619 (Evidence)
UniGene 6822
DFCI TC1575313
DoTS DT.94343660, DT.101308678, DT.482140, DT.103596885
NIA Mouse Gene Index U027823
Consensus CDS Project CCDS20494.1, CCDS39620.1
International Mouse Phenotyping Consortium Status Phc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034663 VEGA Gene Model | MGI Sequence Detail 22769 C57BL/6J ±  kb
transcript OTTMUST00000087975 VEGA | MGI Sequence Detail 3893 Not Applicable 
polypeptide OTTMUSP00000047920 VEGA | MGI Sequence Detail 1010 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(13) UniProt(11)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR012313 Zinc finger, FCS-type
InterPro IPR010507 Zinc finger, MYM-type
Protein Ontology PR:000012633 polyhomeotic-like protein 1
References
(Earliest) J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
(Latest) J:186106 Tavares L, et al., RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell. 2012 Feb 17;148(4):664-78
All references(69)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24124, MGI:2141707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory