Phc1
Gene Detail

Symbol Name ID

Phc1 polyhomeotic-like 1 (Drosophila) MGI:103248

Synonyms

Edr1, Mph1, rae28, Rae-28

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.52 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:122317738-122340506 bp, - strand From VEGA annotation of GRCm38   22769 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:107079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Phc1

Human homologs

Human Homolog		PHC1, polyhomeotic homolog 1 (Drosophila)
NCBI Gene ID		1911
neXtProt AC		NX_P78364
Human Synonyms		EDR1, HPH1, RAE28
Human Chr (Location)		12p13; chr12:9067316-9094063 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(175) : Targeted(5) Gene trapped(170)
 

Homozygous mutant mice exhibit perinatal lethality, posterior skeletal transformations and defects in neural crest derived tissues, including ocular abnormalities, cleft palate, parathyroid and thymic hypoplasia and cardiac anomalies. Hematopoiesis is impaired in fetal livers.

 
Human Diseases Modeled Using Mouse Phc1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cellular response to retinoic acid, multicellular organismal development
Component	nuclear body, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (302)    Tissues (216)    Images (46)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	200
Northern blot	21
Western blot	29
RT-PCR	52

cDNA source data(170)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(179) Genomic(4) cDNA(171) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034663 (Evidence)
Ensembl Gene Model	ENSMUSG00000040669 (Evidence)
Entrez Gene	13619 (Evidence)
UniGene	6822
DFCI	TC1575313
DoTS	DT.101308678, DT.103596885, DT.482140, DT.94343660
NIA Mouse Gene Index	U027823
Consensus CDS Project	CCDS20494.1, CCDS39620.1
International Mouse Knockout Project Status	Phc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034663	VEGA Gene Model | MGI Sequence Detail	22769	C57BL/6J
transcript	OTTMUST00000087975	VEGA | MGI Sequence Detail	3893	Not Applicable
polypeptide	OTTMUSP00000047920	VEGA | MGI Sequence Detail	1010	Not Applicable

All sequences(101) RefSeq(7) UniProt(11)

Polymorphisms

SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR012313	Zinc finger, FCS-type
InterPro	IPR010507	Zinc finger, MYM-type
Protein Ontology	PR:000012633	polyhomeotic-like protein 1

References

(Earliest) J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
(Latest) J:186106 Tavares L, et al., RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell. 2012 Feb 17;148(4):664-78
All references(69)

Other accession IDs

MGD-MRK-24124, MGI:2141707