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Dsc2 Gene Detail
Summary
  • Symbol
    Dsc2
  • Name
    desmocollin 2
  • Synonyms
    Dsc2a, Dsc2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:103221
    NCBI Gene: 13506
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20163690-20192611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    952 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103221
 protein coding gene Chr18:20163690-20192611 (-)
129S1/SvImJ ENSMUSG00200019452
 protein coding gene Chr18:17171336-17200291 (-)
A/J ENSMUSG00195001978
 protein coding gene Chr18:17312532-17341454 (-)
AKR/J ENSMUSG00220011636
 protein coding gene Chr18:17357187-17386109 (-)
BALB/cJ ENSMUSG00180003954
 protein coding gene Chr18:17773899-17802818 (-)
C3H/HeJ ENSMUSG00175004365
 protein coding gene Chr18:17300125-17329045 (-)
C57BL/6NJ ENSMUSG00215003456
 protein coding gene Chr18:17012744-17041669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022022
 protein coding gene Chr18:16235960-16264687 (-)
CAST/EiJ ENSTCUG00005014488
 protein coding gene Chr18:17036676-17065700 (-)
CBA/J ENSMUSG00210020038
 protein coding gene Chr18:17326252-17355162 (-)
DBA/2J ENSMUSG00185007881
 protein coding gene Chr18:17283467-17312374 (-)
FVB/NJ ENSMUSG00205016629
 protein coding gene Chr18:17021699-17050609 (-)
JF1/MsJ ENSUMUG00000017632
 protein coding gene Chr18:17335097-17364001 (-)
LP/J ENSMUSG00230010664
 protein coding gene Chr18:19365439-19394393 (-)
NOD/ShiLtJ ENSMUSG00190016416
 protein coding gene Chr18:17098508-17127415 (-)
NZO/HlLtJ ENSMUSG00225027970
 protein coding gene Chr18:19288445-19317365 (-)
PWK/PhJ ENSLUMG00010015362
 protein coding gene Chr18:17514459-17542090 (-)
SPRET/EiJ ENSMSPG00010004742
 protein coding gene Chr18:17422551-17450452 (-)
WSB/EiJ ENSIUOG00005018665
 protein coding gene Chr18:17187865-17216785 (-)



Homology
more
  • Human Ortholog
    DSC2, desmocollin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSC2, desmocollin 2
  • Synonyms
    ARVD11, CDHF2, DG2, DGII/III, DSC3
  • Links
    NCBI Gene ID: 1824
    UniProt: Q02487

  • Chr Location
    18q12.1; chr18:31058545-31102600 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DSC2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout increases the severity of cardiac pressure overload phenotypes (cardiac hypertrophy and fibrosis, decreased ventricular muscle contractility). Conditional homozygous KO in intestinal epithelial cells does not affect susceptibility to dextran sodium sulfate (DSS)-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    114
  • cDNA Data
    55
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13506 NCBI Gene Model | MGI Sequence Detail 28922 C57BL/6J ±  kb
    transcript NM_001317363 RefSeq | MGI Sequence Detail 4675 Not Specified  
    polypeptide P55292 UniProt | EBI | MGI Sequence Detail 902 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 57
      Primer pair 7
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24091, MGD-MRK-8904, MGI:2147359
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 21
      Gene Ontology 14
      Phenotypes 13
    • Earliest
      J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
    • Latest
      J:391401 Creff J, et al., Goblet cells mechanically breach the epithelial barrier in gut homeostasis. Nat Commun. 2026 Jul 25;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory