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Dsc2
Gene Detail
Symbol

Name
ID
Dsc2
desmocollin 2
MGI:103221
Synonyms
Dsc2a, Dsc2b
Feature Type
protein coding gene
Genetic Map
Chromosome 18
11.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:20030633-20059554 bp, - strand
From VEGA annotation of GRCm38

  28922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: DSC2
Gene Tree: Dsc2

Human
homologs
DSC2, desmocollin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1824
neXtProt AC: NX_Q02487

Human Synonyms: ARVD11, CDHF2, DG2, DGII/III, DSC3

Human Chr (Location): 18q12.1; chr18:31065974-31102432 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DSC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Dsc2 interacts with 363 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (269)    Tissues (105)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 187
RT-PCR 74
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DSC2    NEW 
Molecular
reagents
All nucleic(63) cDNA(56) Primer pair(7)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026419 (Evidence)
Ensembl Gene Model ENSMUSG00000024331 (Evidence)
Entrez Gene 13506 (Evidence)
UniGene 280547
DFCI TC1578372, TC1598648, TC1618705
DoTS DT.101734969, DT.60104811, DT.91342515
NIA Mouse Gene Index U038240
Consensus CDS Project CCDS29077.1
International Mouse Phenotyping Consortium Status Dsc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026419 VEGA Gene Model | MGI Sequence Detail 28922 C57BL/6J ±  kb
transcript OTTMUST00000065336 VEGA | MGI Sequence Detail 4508 Not Applicable 
polypeptide OTTMUSP00000032551 VEGA | MGI Sequence Detail 902 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006693 desmocollin-2
References
(Earliest) J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
(Latest) J:192592 Sotiropoulou PA, et al., BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
All references(48)
Other
accession IDs
MGD-MRK-24091, MGD-MRK-8904, MGI:2147359

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory