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Dsc2
Gene Detail
 Symbol
Name
ID
Dsc2
desmocollin 2
MGI:103221
Synonyms Dsc2a, Dsc2b
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:20030633-20059554 bp, - strand
From VEGA annotation of GRCm38

  28922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Dsc2

Human
homologs
Human Homolog DSC2, desmocollin 2
NCBI Gene ID 1824
neXtProt AC  NX_Q02487
Human Synonyms  ARVD11, CDHF2, DG2, DGII/III, DSC3
Human Chr (Location)  18q12.1; chr18:31065976-31102425 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DSC2
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process bundle of His cell to Purkinje myocyte communication, cardiac muscle cell-cardiac muscle cell adhesion, ...
Component cell-cell adherens junction, cell junction, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (252)    Tissues (84)    Images (33)
Theiler Stages: 2, 3, 4, 5, 20, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 163
RT-PCR 81
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(63) cDNA(56) Primer pair(7)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026419 (Evidence)
Ensembl Gene ModelENSMUSG00000024331 (Evidence)
Entrez Gene13506 (Evidence)
UniGene280547
DFCITC1578372, TC1598648, TC1618705
DoTSDT.101734969, DT.60104811, DT.91342515
NIA Mouse Gene IndexU038240
Consensus CDS ProjectCCDS29077.1
International Mouse Knockout Project StatusDsc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026419 VEGA Gene Model | MGI Sequence Detail 28922 C57BL/6J ±  kb
transcript OTTMUST00000065336 VEGA | MGI Sequence Detail 4508 Not Applicable 
polypeptide OTTMUSP00000032551 VEGA | MGI Sequence Detail 902 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR009124 Cadherin/Desmocollin
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006693 desmocollin-2
References (Earliest) J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
(Latest) J:192592 Sotiropoulou PA, et al., BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
All references(49)
Other
accession IDs
MGD-MRK-24091, MGD-MRK-8904, MGI:2147359

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory