Dsc2
Gene Detail

Symbol Name ID

Dsc2 desmocollin 2 MGI:103221

Synonyms

Dsc2a, Dsc2b

Feature Type

protein coding gene

Genetic Map

Chromosome 18

11.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:20030633-20059554 bp, - strand From VEGA annotation of GRCm38   28922 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Dsc2

Human homologs

Human Homolog		DSC2, desmocollin 2
NCBI Gene ID		1824
neXtProt AC		NX_Q02487
Human Synonyms		ARVD11, CDHF2, DG2, DGII/III, DSC3
Human Chr (Location)		18q12.1; chr18:28645942-28682388 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DSC2

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	bundle of His cell to Purkinje myocyte communication, cell adhesion, ...
Component	cell-cell adherens junction, cell junction, ...
Function	calcium ion binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (252)    Tissues (84)    Images (33)
Theiler Stages: 2, 3, 4, 5, 20, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	163
RT-PCR	81

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) cDNA(22) Primer pair(7)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026419 (Evidence)
Ensembl Gene Model	ENSMUSG00000024331 (Evidence)
Entrez Gene	13506 (Evidence)
DFCI	TC1578372, TC1598648, TC1618705
DoTS	DT.101734969, DT.60104811, DT.91342515
NIA Mouse Gene Index	U038240
Consensus CDS Project	CCDS29077.1
International Mouse Knockout Project Status	Dsc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026419	VEGA Gene Model | MGI Sequence Detail	28922	C57BL/6J
transcript	OTTMUST00000065336	VEGA | MGI Sequence Detail	4508	Not Applicable
polypeptide	OTTMUSP00000032551	VEGA | MGI Sequence Detail	902	Not Applicable

All sequences(50) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR015919	Cadherin-like
InterPro	IPR014868	Cadherin prodomain
InterPro	IPR009124	Desmocollin
InterPro	IPR009122	Desmosomal cadherin
Protein Ontology	PR:000006693	desmocollin-2

References

(Earliest) J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
(Latest) J:192592 Sotiropoulou PA, et al., BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
All references(47)

Other accession IDs

MGD-MRK-24091, MGD-MRK-8904, MGI:2147359