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Meox2
Gene Detail
Symbol

Name
ID
Meox2
mesenchyme homeobox 2
MGI:103219
Synonyms
Gax, Mox2, Mox-2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
16.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:37108540-37179534 bp, + strand
From VEGA annotation of GRCm38

  70995 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Meox2

Human
homologs
Human Homolog MEOX2, mesenchyme homeobox 2
NCBI Gene ID 4223
neXtProt AC  NX_P50222
Human Synonyms  GAX, MOX2
Human Chr (Location)  7p22.1-p21.3; chr7:15611212-15686683 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Several mutations that inactivate the gene result in mild defects of rib and vertebrae development. Inactivation in conjunction with a null mutation in a related homeobox gene results in more severe defects stemming from impaired somite formation, patterning, and differentiation.
 
Interactions
Meox2 interacts with 364 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process angiogenesis, limb development, ...
Component cytoplasm, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (365)    Tissues (152)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 330
Northern blot 10
Western blot 10
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037527 (Evidence)
Ensembl Gene ModelENSMUSG00000036144 (Evidence)
Entrez Gene17286 (Evidence)
UniGene341398
DFCITC1581539
DoTSDT.489684
NIA Mouse Gene IndexU040763
Consensus CDS ProjectCCDS25888.1
International Mouse Knockout Project StatusMeox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037527 VEGA Gene Model | MGI Sequence Detail 70995 C57BL/6J ±  kb
transcript OTTMUST00000096749 VEGA | MGI Sequence Detail 2360 Not Applicable 
polypeptide OTTMUSP00000054091 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(656 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010323 homeobox protein MOX-2
References
(Earliest) J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
(Latest) J:213764 Hasenfuss SC, et al., Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism. Hepatology. 2014 Jan;59(1):261-73
All references(273)
Other
accession IDs
MGD-MRK-12395, MGD-MRK-12397, MGD-MRK-24089, MGI:2144856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory