Cdc25a
Gene Detail

Symbol Name ID

Cdc25a cell division cycle 25A MGI:103198

Synonyms

D9Ertd393e

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:109875579-109893888 bp, + strand From Ensembl annotation of GRCm38   18310 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cdc25a ± 2 cM)

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25a

Human ortholog

CDC25A cell division cycle 25A NCBI Gene ID 993
Human Synonyms: CDC25A2
Human Chr3:48198668-48229801 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(13) : Targeted(7) Gene trapped(5) Spontaneous(1)
 

Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, intracellular, ...
Function	hydrolase activity, phosphoprotein phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
cDNA source data(91)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000032477 (Evidence)
Entrez Gene	12530 (Evidence)
UniGene	307103
DFCI	TC1579218, TC1603873, TC1721992
DoTS	DT.101305140, DT.533614, DT.94276577
NIA Mouse Gene Index	U011057
EC	3.1.3.48
Consensus CDS Project	CCDS23559.1
International Mouse Knockout Project Status	Cdc25a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032477	Ensembl Gene Model | MGI Sequence Detail	18310	C57BL/6J
transcript	ENSMUST00000094324	Ensembl | MGI Sequence Detail	3625	Not Applicable
polypeptide	ENSMUSP00000091882	Ensembl | MGI Sequence Detail	514	Not Applicable

All sequences(33) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000751	M-phase inducer phosphatase
InterPro	IPR001763	Rhodanese-like domain
Protein Ontology	PR:000005191	M-phase inducer phosphatase 1

References

(Earliest) J:18478 Gariboldi M, et al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994 May 15;21(2):451-3
(Latest) J:191020 Yanagida J, et al., Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin. Carcinogenesis. 2012 Sep;33(9):1754-61
All references(57)

Other accession IDs

MGD-MRK-24066, MGI:1196333