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Cdc25a
Gene Detail
 Symbol
Name
ID
Cdc25a
cell division cycle 25A
MGI:103198
Synonyms D9Ertd393e
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:109875579-109893888 bp, + strand
From Ensembl annotation of GRCm38

  18310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25a

Human
homologs
Human Homolog CDC25A, cell division cycle 25A
NCBI Gene ID 993
neXtProt AC  NX_P30304
Human Synonyms  CDC25A2
Human Chr (Location)  3p21; chr3:48157178-48188311 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone.
 
Interactions
Cdc25a interacts with 248 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, intracellular, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (49)    Images (11)
Theiler Stages: 1, 11, 13, 15, 17, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 25
Northern blot 8
RNase protection 22
cDNA source data(91)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032477 (Evidence)
Entrez Gene12530 (Evidence)
UniGene307103
DFCITC1579218, TC1603873, TC1721992
DoTSDT.101305140, DT.533614, DT.94276577
NIA Mouse Gene IndexU011057
EC3.1.3.48
Consensus CDS ProjectCCDS23559.1
International Mouse Knockout Project StatusCdc25a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032477 Ensembl Gene Model | MGI Sequence Detail 18310 C57BL/6J ±  kb
transcript ENSMUST00000094324 Ensembl | MGI Sequence Detail 3625 Not Applicable 
polypeptide ENSMUSP00000091882 Ensembl | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005191 M-phase inducer phosphatase 1
References (Earliest) J:18478 Gariboldi M, et al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994 May 15;21(2):451-3
(Latest) J:205127 Masyuk TV, et al., Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. Am J Pathol. 2014 Jan;184(1):110-21
All references(61)
Other
accession IDs
MGD-MRK-24066, MGI:1196333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory