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Cdc25a Gene Detail
Summary
  • Symbol
    Cdc25a
  • Name
    cell division cycle 25A
  • Synonyms
    D9Ertd393e
  • Feature Type
    protein coding gene
  • IDs
    MGI:103198
    NCBI Gene: 12530
  • Gene Overview
    MyGene.info: CDC25A
Location & Maps
more
  • Sequence Map
    Chr9:109875579-109893895 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18317 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.81 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CDC25A, cell division cycle 25A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC25A, cell division cycle 25A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC25A2
  • Links
    NCBI Gene ID: 993
    neXtProt AC: NX_P30304

  • Chr Location
    3p21; chr3:48157178-48188658 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    5
  • Spontaneous
    1
  • Targeted
    7
  • Incidental Mutations
Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051511 VEGA Gene Model | MGI Sequence Detail 18317 C57BL/6J ±  kb
transcript OTTMUST00000130111 VEGA | MGI Sequence Detail 3632 Not Applicable  
polypeptide OTTMUSP00000069797 VEGA | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 95
    cDNA 94
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-24066, MGI:1196333
References
more
  • Summaries
    All 61
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:18478 Gariboldi M, et al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994 May 15;21(2):451-3
  • Latest
    J:218049 Houlihan SL, et al., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory