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Cdc25a
Gene Detail
Symbol

Name
ID
Cdc25a
cell division cycle 25A
MGI:103198
Synonyms
D9Ertd393e
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:109875579-109893895 bp, + strand
From VEGA annotation of GRCm38

  18317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDC25A
Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25a

Human
homologs
CDC25A, cell division cycle 25A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 993
neXtProt AC: NX_P30304

Human Synonyms: CDC25A2

Human Chr (Location): 3p21; chr3:48157178-48188658 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone.
 
Interactions
Cdc25a interacts with 248 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, intracellular, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (55)    Tissues (49)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 8
RNase protection 22
cDNA source data(91)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDC25A ; Xenbase cdc25a    NEW 
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000051511 (Evidence)
Ensembl Gene Model ENSMUSG00000032477 (Evidence)
Entrez Gene 12530 (Evidence)
UniGene 307103
DFCI TC1579218, TC1603873, TC1721992
DoTS DT.101305140, DT.533614, DT.94276577
NIA Mouse Gene Index U011057
EC 3.1.3.48
Consensus CDS Project CCDS23559.1
International Mouse Phenotyping Consortium Status Cdc25a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051511 VEGA Gene Model | MGI Sequence Detail 18317 C57BL/6J ±  kb
transcript OTTMUST00000130111 VEGA | MGI Sequence Detail 3632 Not Applicable 
polypeptide OTTMUSP00000069797 VEGA | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005191 M-phase inducer phosphatase 1
References
(Earliest) J:18478 Gariboldi M, et al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994 May 15;21(2):451-3
(Latest) J:218049 Houlihan SL, et al., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
All references(64)
Other
accession IDs
MGD-MRK-24066, MGI:1196333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory