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Sod3 Gene Detail
Summary
  • Symbol
    Sod3
  • Name
    superoxide dismutase 3, extracellular
  • Synonyms
    EC-SOD, MGC:13799
  • Feature Type
    protein coding gene
  • IDs
    MGI:103181
    NCBI Gene: 20657
  • Gene Overview
    MyGene.info: SOD3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52363804-52369738 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.92 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103181
protein coding gene Chr5:52363791-52371418 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029544
protein coding gene Chr5:51334839-51342707 (+)
A/J MGP_AJ_G0029512
protein coding gene Chr5:49546979-49554605 (+)
AKR/J MGP_AKRJ_G0029460
protein coding gene Chr5:51214486-51222171 (+)
BALB/cJ MGP_BALBcJ_G0029521
protein coding gene Chr5:50012045-50019683 (+)
C3H/HeJ MGP_C3HHeJ_G0029244
protein coding gene Chr5:51382166-51389860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029975
protein coding gene Chr5:53472655-53480341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027215
protein coding gene Chr5:46318258-46325950 (+)
CAST/EiJ MGP_CASTEiJ_G0028652
protein coding gene Chr5:50389257-50397541 (+)
CBA/J MGP_CBAJ_G0029213
protein coding gene Chr5:55106855-55117100 (+)
DBA/2J MGP_DBA2J_G0029359
protein coding gene Chr5:49597455-49605849 (+)
FVB/NJ MGP_FVBNJ_G0029319
protein coding gene Chr5:48939433-48947056 (+)
LP/J MGP_LPJ_G0029444
protein coding gene Chr5:51797280-51806062 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029347
protein coding gene Chr5:56208626-56217042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030008
protein coding gene Chr5:50708000-50715607 (+)
PWK/PhJ MGP_PWKPhJ_G0028376
protein coding gene Chr5:48662719-48670682 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028210
protein coding gene Chr5:50159595-50167245 (+)
WSB/EiJ MGP_WSBEiJ_G0028733
protein coding gene Chr5:50754413-50763053 (+)



Homology
more
  • Human Ortholog
    SOD3, superoxide dismutase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD3, superoxide dismutase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EC-SOD
  • Links
    NCBI Gene ID: 6649
    neXtProt AC: NX_P08294
    UniProt: P08294

  • Chr Location
    4p15.2; chr4:24795463-24800845 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to hyperoxia, increased LPS-stimulated spleen production of TNF, and enhanced severity of collagen-induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20657 NCBI Gene Model | MGI Sequence Detail 5935 C57BL/6J ±  kb
    transcript NM_011435 RefSeq | MGI Sequence Detail 2045 C57BL/6 x CBA  
    polypeptide O09164 UniProt | EBI | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015401 extracellular superoxide dismutase [Cu-Zn]
    • PDB
    • EC
    • InterPro Domains
      IPR001424 Superoxide dismutase, copper/zinc binding domain
      IPR018152 Superoxide dismutase, copper/zinc, binding site
      IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
      IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 87
      Genomic 1
      cDNA 83
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24049, MGI:2140829
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 76
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:257671 Mouradian GC, et al., Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation. Am J Respir Cell Mol Biol. 2017 Mar;56(3):362-371

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory