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Sod3 Gene Detail
Summary
  • Symbol
    Sod3
  • Name
    superoxide dismutase 3, extracellular
  • Synonyms
    EC-SOD, MGC:13799
  • Feature Type
    protein coding gene
  • IDs
    MGI:103181
    NCBI Gene: 20657
  • Gene Overview
    MyGene.info: SOD3
Location & Maps
more
  • Sequence Map
    Chr5:52363791-52371418 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7628 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.92 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    SOD3, superoxide dismutase 3, extracellular
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD3, superoxide dismutase 3, extracellular
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EC-SOD
  • Links
    NCBI Gene ID: 6649
    neXtProt AC: NX_P08294

  • Chr Location
    4p15.2; chr4:24795463-24800845 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    4 involving Sod3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased sensitivity to hyperoxia, increased LPS-stimulated spleen production of TNF, and enhanced severity of collagen-induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054570 VEGA Gene Model | MGI Sequence Detail 7628 C57BL/6J ±  kb
transcript OTTMUST00000135268 VEGA | MGI Sequence Detail 3738 Not Applicable  
polypeptide OTTMUSP00000071606 VEGA | MGI Sequence Detail 251 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    104 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 86
    Genomic 1
    cDNA 82
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-24049, MGI:2140829
References
more
  • Summaries
    All 108
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 76
  • Earliest
    J:16586 Chun YS, et al., Effect of superoxide dismutase on the development of preimplantation mouse embryos. Theriogenology. 1994 Feb;41(2):511-20
  • Latest
    J:234575 Bhattacharya A, et al., Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity. 2015 Nov 17;43(5):974-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory