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Sod3
Gene Detail
Symbol

Name
ID
Sod3
superoxide dismutase 3, extracellular
MGI:103181
Synonyms
EC-SOD, MGC:13799
Feature Type
protein coding gene
Genetic Map
Chromosome 5
27.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:52363804-52369738 bp, + strand
From NCBI annotation of GRCm38

  5935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOD3
Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod3

Human
homologs
SOD3, superoxide dismutase 3, extracellular
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6649
neXtProt AC: NX_P08294

Human Synonyms: EC-SOD

Human Chr (Location): 4p15.2; chr4:24795463-24800845 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(1) Targeted(5)
Genomic Mutations involving Sod3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to hyperoxia, increased LPS-stimulated spleen production of TNF, and enhanced severity of collagen-induced arthritis.
 
Phenotype Images(4)
Interactions
Sod3 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process oxidation-reduction process, removal of superoxide radicals, ...
Component cytoplasm, extracellular exosome, ...
Function antioxidant activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (300)    Tissues (235)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 254
Western blot 22
RT-PCR 24
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sod3 ; ZFIN sod3a, sod3b    NEW 
Molecular
reagents
All nucleic(86) Genomic(1) cDNA(82) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000072941 (Evidence)
Entrez Gene 20657 (Evidence)
UniGene 2407
DFCI TC1578284
DoTS DT.533631
NIA Mouse Gene Index U005577
EC 1.15.1.1
PDB 2DZ2, 2DZ3
Consensus CDS Project CCDS19283.1
International Mouse Phenotyping Consortium Status Sod3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20657 NCBI Gene Model | MGI Sequence Detail 5935 C57BL/6J ±  kb
transcript NM_011435 RefSeq | MGI Sequence Detail 2045 C57BL/6 x CBA 
polypeptide O09164 UniProt | EBI | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
InterPro IPR024141 Superoxide dismutase (Cu/Zn), extracellular
Protein Ontology PR:000015401 extracellular superoxide dismutase [Cu-Zn]
Graphical View of Protein Domain Structure
References
(Earliest) J:16586 Chun YS, et al., Effect of superoxide dismutase on the development of preimplantation mouse embryos. Theriogenology. 1994 Feb;41(2):511-20
(Latest) J:212043 Gottfredsen RH, et al., The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution. Free Radic Biol Med. 2014 Apr;69:348-56
All references(104)
Other
accession IDs
MGD-MRK-24049, MGI:2140829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory