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Sod3
Gene Detail
 Symbol
Name
ID
Sod3
superoxide dismutase 3, extracellular
MGI:103181
Synonyms EC-SOD, MGC:13799
Feature Type protein coding gene
Genetic Map
Chromosome 5
27.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:52363804-52369738 bp, + strand
From NCBI annotation of GRCm38

  5935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod3

Human
homologs
Human Homolog SOD3, superoxide dismutase 3, extracellular
NCBI Gene ID 6649
neXtProt AC  NX_P08294
Human Synonyms  EC-SOD
Human Chr (Location)  4p15.2; chr4:24795463-24800845 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to hyperoxia, increased LPS-stimulated spleen production of TNF, and enhanced severity of collagen-induced arthritis.
 
Interactions
Sod3 interacts with 251 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process oxidation-reduction process, removal of superoxide radicals, ...
Component cytoplasm, extracellular matrix, ...
Function antioxidant activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (300)    Tissues (235)    Images (52)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 254
Western blot 22
RT-PCR 24
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(1) cDNA(82) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000072941 (Evidence)
Entrez Gene20657 (Evidence)
UniGene2407
DFCITC1578284
DoTSDT.533631
NIA Mouse Gene IndexU005577
EC1.15.1.1
PDB2DZ2, 2DZ3
Consensus CDS ProjectCCDS19283.1
International Mouse Knockout Project StatusSod3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20657 NCBI Gene Model | MGI Sequence Detail 5935 C57BL/6J ±  kb
transcript NM_011435 RefSeq | MGI Sequence Detail 2045 C57BL/6 x CBA 
polypeptide O09164 UniProt | EBI | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
InterPro IPR024141 Superoxide dismutase (Cu/Zn), extracellular
Protein Ontology PR:000015401 extracellular superoxide dismutase [Cu-Zn]
Graphical View of Protein Domain Structure
References (Earliest) J:16586 Chun YS, et al., Effect of superoxide dismutase on the development of preimplantation mouse embryos. Theriogenology. 1994 Feb;41(2):511-20
(Latest) J:211582 Stepp MW, et al., The c10orf10 gene product is a new link between oxidative stress and autophagy. Biochim Biophys Acta. 2014 Jun;1843(6):1076-88
All references(105)
Other
accession IDs
MGD-MRK-24049, MGI:2140829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory