About   Help   FAQ
Mpz
Gene Detail
Symbol

Name
ID
Mpz
myelin protein zero
MGI:103177
Synonyms
Mpp, P0
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr1:171150711-171161130 bp, + strand
From VEGA annotation of GRCm38

  10420 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: myelin P0 protein
Gene Tree: Mpz

Human
homologs
Human Homolog MPZ, myelin protein zero
NCBI Gene ID 4359
neXtProt AC  NX_P25189
Human Synonyms  CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0
Human Chr (Location)  1q23.3; chr1:161304735-161309972 (-)  GRCh38
Disease Associations  (7) Diseases Associated with Human MPZ
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(6) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation exhibit premature death, infertility, neurological behavior defects, and demyelination. Mice homozygous for a knock-out allele exhibit abnormal myelination and neurological behavior defects.
 
Human Diseases Modeled Using Mouse Mpz (3)    Alleles Annotated to Human Diseases(1)   
Interactions
Mpz interacts with 250 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell-cell junction maintenance
Component integral component of membrane, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (102)    Tissues (16)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 95
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021546 (Evidence)
Ensembl Gene ModelENSMUSG00000056569 (Evidence)
Entrez Gene17528 (Evidence)
DFCITC1574855
DoTSDT.94232526, DT.101403499
NIA Mouse Gene IndexU001078
Consensus CDS ProjectCCDS15479.1
International Mouse Knockout Project StatusMpz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021546 VEGA Gene Model | MGI Sequence Detail 10420 C57BL/6J ±  kb
transcript OTTMUST00000051092 VEGA | MGI Sequence Detail 2002 Not Applicable 
polypeptide OTTMUSP00000023997 VEGA | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR000920 Myelin P0 protein
InterPro IPR019738 Myelin P0 protein, conserved site
InterPro IPR019566 Myelin-PO, C-terminal
Protein Ontology PR:000010553 myelin P0 protein
References
(Earliest) J:10329 Popko B, et al., A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts. Neuron. 1988 May;1(3):221-5
(Latest) J:210607 Jacob C, et al., HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. J Neurosci. 2014 Apr 23;34(17):6112-22
All references(125)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12531, MGD-MRK-24045

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory