About   Help   FAQ
Mpz Gene Detail
Summary
  • Symbol
    Mpz
  • Name
    myelin protein zero
  • Synonyms
    Mpp, P0
  • Feature Type
    protein coding gene
  • IDs
    MGI:103177
    NCBI Gene: 17528
  • Gene Overview
    MyGene.info: MPZ
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171150713-171161130 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.05 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103177
protein coding gene Chr1:171150711-171161130 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016743
protein coding gene Chr1:176928251-176938671 (+)
A/J MGP_AJ_G0016723
protein coding gene Chr1:169732660-169743047 (+)
AKR/J MGP_AKRJ_G0016689
protein coding gene Chr1:174810053-174822151 (+)
BALB/cJ MGP_BALBcJ_G0016684
protein coding gene Chr1:170213960-170224639 (+)
C3H/HeJ MGP_C3HHeJ_G0016507
protein coding gene Chr1:175061447-175072955 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017145
protein coding gene Chr1:182810964-182821392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014853
protein coding gene Chr1:161409924-161420578 (+)
CAST/EiJ MGP_CASTEiJ_G0016088
protein coding gene Chr1:174685017-174695407 (+)
CBA/J MGP_CBAJ_G0016482
protein coding gene Chr1:189319978-189332687 (+)
DBA/2J MGP_DBA2J_G0016589
protein coding gene Chr1:168571306-168581745 (+)
FVB/NJ MGP_FVBNJ_G0016585
protein coding gene Chr1:166920261-166930939 (+)
LP/J MGP_LPJ_G0016660
protein coding gene Chr1:178050788-178062582 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016612
protein coding gene Chr1:196606851-196619227 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017182
protein coding gene Chr1:174686347-174696732 (+)
PWK/PhJ MGP_PWKPhJ_G0015874
protein coding gene Chr1:167792708-167803174 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015658
protein coding gene Chr1:173476899-173487402 (+)
WSB/EiJ MGP_WSBEiJ_G0016150
protein coding gene Chr1:174803135-174814285 (+)



Homology
more
  • Human Ortholog
    MPZ, myelin protein zero
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPZ, myelin protein zero
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0
  • Links
    NCBI Gene ID: 4359
    neXtProt AC: NX_P25189
    UniProt: P25189

  • Chr Location
    1q23.3; chr1:161303593-161309972 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Mpz mouse models; 6 with human MPZ associations

Human Disease Mouse Models
      
IDs
View 4 models
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 8 alleles in 9 genetic backgrounds
    20 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit premature death, infertility, neurological behavior defects, and demyelination. Mice homozygous for a knock-out allele exhibit abnormal myelination and neurological behavior defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17528 NCBI Gene Model | MGI Sequence Detail 10418 C57BL/6J ±  kb
    transcript NM_008623 RefSeq | MGI Sequence Detail 2018 C57BL/6  
    polypeptide P27573 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 12
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12531, MGD-MRK-24045
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 34
      Diseases 4
      Gene Ontology 7
      Phenotypes 61
    • Earliest
      J:10329 Popko B, et al., A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts. Neuron. 1988 May;1(3):221-5
    • Latest
      J:264858 Krzyzosiak A, et al., Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory