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F10 Gene Detail
Summary
  • Symbol
    F10
  • Name
    coagulation factor X
  • Synonyms
    AI194738, Cf10, fX
  • Feature Type
    protein coding gene
  • IDs
    MGI:103107
    NCBI Gene: 14058
  • Gene Overview
    MyGene.info: F10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:13037308-13056676 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19369 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    F10, coagulation factor X
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F10, coagulation factor X
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FX, FXA
  • Links
    NCBI Gene ID: 2159
    neXtProt AC: NX_P00742
    UniProt: P00742

  • Chr Location
    13q34; chr13:113122799-113149529 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous mice die from fatal bleeding events at embryonic and neonatal stages, with the remaining homozygous mice dying before weaning stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020614 VEGA Gene Model | MGI Sequence Detail 19369 C57BL/6J ±  kb
    transcript OTTMUST00000048845 VEGA | MGI Sequence Detail 1903 Not Applicable  
    polypeptide OTTMUSP00000022500 VEGA | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      335 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • EC
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
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    • All nucleic 48
      Genomic 3
      cDNA 44
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
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    MGD-MRK-23971, MGI:2142475
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:24375 Koizumi T, et al., Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8
    • Latest
      J:241576 Schuliga M, et al., Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity. Am J Physiol Lung Cell Mol Physiol. 2017 May 01;312(5):L772-L782

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory