About   Help   FAQ
F10
Gene Detail
Symbol

Name
ID
F10
coagulation factor X
MGI:103107
Synonyms
AI194738, Cf10, fX
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:13037308-13056676 bp, + strand
From VEGA annotation of GRCm38

  19369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F10

Human
homologs
Human Homolog F10, coagulation factor X
NCBI Gene ID 2159
neXtProt AC  NX_P00742
Human Synonyms  FX, FXA
Human Chr (Location)  13q34; chr13:113122799-113149529 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human F10
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous mice die from fatal bleeding events at embryonic and neonatal stages, with the remaining homozygous mice dying before weaning stages.
 
Human Diseases Modeled Using Mouse F10 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
F10 interacts with 111 markers (Mir18, Mir18b, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, intracellular membrane-bounded organelle, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (16)    Tissues (14)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 14
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(3) cDNA(44) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000020614 (Evidence)
Ensembl Gene ModelENSMUSG00000031444 (Evidence)
Entrez Gene14058 (Evidence)
UniGene262589
DFCITC1714471, TC1580724, TC1591908
DoTSDT.489445, DT.101366437, DT.97385990, DT.524211
NIA Mouse Gene IndexU009098
EC3.4.21.6
Consensus CDS ProjectCCDS40226.1, CCDS57606.1
International Mouse Knockout Project StatusF10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020614 VEGA Gene Model | MGI Sequence Detail 19369 C57BL/6J ±  kb
transcript OTTMUST00000048845 VEGA | MGI Sequence Detail 1903 Not Applicable 
polypeptide OTTMUSP00000022500 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(17)
Polymorphisms
RFLP(2) : SNPs within 2kb(351 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007294 coagulation factor X
References
(Earliest) J:24375 Koizumi T, et al., Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8
(Latest) J:203644 Funnell AP, et al., A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. Am J Hum Genet. 2013 Mar 7;92(3):460-7
All references(44)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-23971, MGI:2142475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory