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Wee1 Gene Detail
Summary
  • Symbol
    Wee1
  • Name
    WEE 1 homolog 1 (S. pombe)
  • Synonyms
    Wee1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:103075
    NCBI Gene: 22390
  • Gene Overview
    MyGene.info: WEE1
Location & Maps
more
  • Sequence Map
    Chr7:110122046-110143286 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21241 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WEE1A, WEE1hu
  • Links
    NCBI Gene ID: 7465
    neXtProt AC: NX_P30291

  • Chr Location
    11p15.4; chr11:9573650-9593458 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    38
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Wee1
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031016 Ensembl Gene Model | MGI Sequence Detail 21241 C57BL/6J ±  kb
transcript ENSMUST00000033326 Ensembl | MGI Sequence Detail 3419 Not Applicable  
polypeptide ENSMUSP00000033326 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    165 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 88
    Genomic 1
    cDNA 87

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23939
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:26519 Honda R, et al., Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Chromosome Res. 1995 Aug;3(5):300-8
  • Latest
    J:222532 Vassilopoulos A, et al., WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015 Jun 4;34(23):3023-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory