About   Help   FAQ
Wee1 Gene Detail
Summary
  • Symbol
    Wee1
  • Name
    WEE 1 homolog 1 (S. pombe)
  • Synonyms
    Wee1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:103075
    NCBI Gene: 22390
  • Gene Overview
    MyGene.info: WEE1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:110122046-110143286 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21241 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WEE1, WEE1 G2 checkpoint kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WEE1A, WEE1hu
  • Links
    NCBI Gene ID: 7465
    neXtProt AC: NX_P30291
    UniProt: P30291

  • Chr Location
    11p15.4; chr11:9573681-9589767 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060172 VEGA Gene Model | MGI Sequence Detail 21241 C57BL/6J ±  kb
    transcript OTTMUST00000147281 VEGA | MGI Sequence Detail 3419 Not Applicable  
    polypeptide OTTMUSP00000076660 VEGA | MGI Sequence Detail 646 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      165 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      Genomic 1
      cDNA 88

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23939
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:242317 Tan J, et al., Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory