Wee1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wee1
WEE 1 homolog 1 (S. pombe)
MGI:103075

15 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(CAG-cre/Esr1)5Amc/0 Wee1^tm1Cxd/Wee1^tm1Cxd involves: 129S6/SvEvTac C57BL/6 * CBA	abnormal cell cycle checkpoint function	J:228492
	abnormal cell morphology	J:228492
	increased apoptosis	J:228492
Wee1^{Tg(Tyr)2416BOve}/Wee1^{Tg(Tyr)2416BOve} FVB/N-Wee1^{Tg(Tyr)2416BOve}	embryonic lethality between implantation and somite formation	J:175597
Wee1^tm1.1Cxd/Wee1^tm1.1Cxd involves: 129S6/SvEvTac * FVB/N	abnormal cell cycle checkpoint function	J:228492
	decreased embryonic epiblast cell proliferation	J:228492
	embryonic lethality before implantation, incomplete penetrance	J:228492
	embryonic lethality between implantation and somite formation, complete penetrance	J:228492
	increased cellular sensitivity to gamma-irradiation	J:228492
	increased embryonic epiblast cell apoptosis	J:228492
Wee1^{tm1b(EUCOMM)Wtsi}/Wee1⁺ C57BL/6N-Wee1^{tm1b(EUCOMM)Wtsi}/Tcp	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	increased circulating alanine transaminase level	J:211773
Wee1^{tm1b(EUCOMM)Wtsi}/Wee1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Wee1^{tm1b(EUCOMM)Wtsi}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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