Rangap1 MGI Mouse Gene Detail - MGI:103071 - RAN GTPase activating protein 1

Symbol

Rangap1
Name

RAN GTPase activating protein 1
Synonyms

Fug1

Feature Type

protein coding gene
IDs

MGI:103071
NCBI Gene: 19387
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:81588449-81614120 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.21 cM
Mapping Data

4 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103071	protein coding gene	Chr15:81588449-81629731 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022118	protein coding gene	Chr15:82158590-82187729 (-)
A/J	MGP_AJ_G0022079	protein coding gene	Chr15:79260484-79285579 (-)
AKR/J	MGP_AKRJ_G0022054	protein coding gene	Chr15:81454995-81480859 (-)
BALB/cJ	MGP_BALBcJ_G0022085	protein coding gene	Chr15:79305120-79330084 (-)
C3H/HeJ	MGP_C3HHeJ_G0021856	protein coding gene	Chr15:81471108-81500354 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022528	protein coding gene	Chr15:85384303-85413814 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020057	protein coding gene	Chr15:75719088-75743910 (-)
CAST/EiJ	MGP_CASTEiJ_G0021376	protein coding gene	Chr15:82241288-82270440 (-)
CBA/J	MGP_CBAJ_G0021820	protein coding gene	Chr15:88038499-88070592 (-)
DBA/2J	MGP_DBA2J_G0021950	protein coding gene	Chr15:78739401-78764447 (-)
FVB/NJ	MGP_FVBNJ_G0021927	protein coding gene	Chr15:77778385-77803262 (-)
LP/J	MGP_LPJ_G0022018	protein coding gene	Chr15:82309254-82336956 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021948	protein coding gene	Chr15:92986838-93013878 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022542	protein coding gene	Chr15:81546483-81575968 (-)
PWK/PhJ	MGP_PWKPhJ_G0021118	protein coding gene	Chr15:78776993-78802530 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020955	protein coding gene	Chr15:81339671-81366311 (-)
WSB/EiJ	MGP_WSBEiJ_G0021428	protein coding gene	Chr15:81964260-81992662 (-)

Human Ortholog

RANGAP1, Ran GTPase activating protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RANGAP1, Ran GTPase activating protein 1
Synonyms

Fug1, RANGAP, SD
Links

HGNC:9854

NCBI Gene ID: 5905

neXtProt AC: NX_P46060

UniProt: P46060
Chr Location

22q13.2; chr22:41244779-41302369 (-) GRCh38

MGI Vertebrate Homology

Rangap1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RANGAP1
Gene Tree

Rangap1

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

60
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Rangap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in embryo arrest at the egg cylinder stage and lethality by E8.5. The appearance of the proamniotic cavity is delayed and epiblast cells surrounding the cavity are disorganized. Mesoderm and placental development is impaired.

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All GO Annotations

46
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

19
cDNA Data

21
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rangap1

ZFIN rangap1b

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All Sequences

90
RefSeq

8
UniProt

10
CCDS

CCDS27670.1

Ensembl

ENSMUSG00000022391 (Evidence)
NCBI Gene

19387

			Length	Strain/Species	Flank
genomic	19387	NCBI Gene Model \| MGI Sequence Detail	25672	C57BL/6J	± kb
transcript	NM_001358622	RefSeq \| MGI Sequence Detail	3163	ZRU/MplStud
polypeptide	P46061	UniProt \| EBI \| MGI Sequence Detail	589	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000013717 Ran GTPase-activating protein 1

(term hierarchy)
PDB

1KPS
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR027038 Ran GTPase-activating protein

IPR009109 Ran-GTPase activating protein 1, C-terminal

IPR036720 Ran-GTPase activating protein 1, C-terminal domain superfamily

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All nucleic 26

Genomic 1

cDNA 22

Primer pair 1

Other 2

Microarray probesets 5

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MGD-MRK-16762, MGD-MRK-23935, MGI:2146294

Summaries

All 79

Developmental Gene Expression 10

Diseases 1

Gene Ontology 10

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:333345 Gong Y, et al., Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma. Dev Cell. 2023 Feb 6;58(3):192-210.e11

TSS for Rangap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135501	Chr15:81614065-81614114 (-)	30 bp
Tssr135500	Chr15:81614052-81614055 (-)	66 bp
Tssr135499	Chr15:81614034-81614045 (-)	80 bp
Tssr135498	Chr15:81610430-81610471 (-)	3,669 bp
Tssr135497	Chr15:81610422-81610427 (-)	3,695 bp
Tssr135496	Chr15:81596756-81596775 (-)	17,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23