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Rangap1
Gene Detail
Symbol

Name
ID
Rangap1
RAN GTPase activating protein 1
MGI:103071
Synonyms
Fug1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:81704248-81729919 bp, - strand
From NCBI annotation of GRCm38

  25672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport
Gene Tree: Rangap1

Human
homologs
Human Homolog RANGAP1, Ran GTPase activating protein 1
NCBI Gene ID 5905
neXtProt AC  NX_P46060
Human Synonyms  Fug1, RANGAP, SD
Human Chr (Location)  22q13; chr22:41244777-41286251 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(69) Radiation induced(1) Targeted(2)
Genomic Mutations involving Rangap1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryo arrest at the egg cylinder stage and lethality by E8.5. The appearance of the proamniotic cavity is delayed and epiblast cells surrounding the cavity are disorganized. Mesoderm and placental development is impaired.
 
Interactions
Rangap1 interacts with 107 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (67)    Tissues (18)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 59
Northern blot 8
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022391 (Evidence)
Entrez Gene19387 (Evidence)
DoTSDT.101294381, DT.101134723, DT.55206242, DT.55107724, DT.101398786, DT.97385911
PDB1KPS
Consensus CDS ProjectCCDS27670.1
International Mouse Knockout Project StatusRangap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19387 NCBI Gene Model | MGI Sequence Detail 25672 C57BL/6J ±  kb
transcript NM_011241 RefSeq | MGI Sequence Detail 3002 C57BL/6 
polypeptide P46061 UniProt | EBI | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(11) UniProt(15)
Polymorphisms
RFLP(1) : SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027038 Ran GTPase-activating protein
InterPro IPR009109 Ran-GTPase activating protein 1, C-terminal
Protein Ontology PR:000013717 ran GTPase-activating protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
(Latest) J:183651 Kim EY, et al., Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012 Mar;52(3):638-49
All references(46)
Other
accession IDs
MGD-MRK-16762, MGD-MRK-23935, MGI:2146294

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory