Sequence Detail

ID/Version

P46061 Q6NZB5 Q60801 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Ran GTPase-activating protein 1; Short=RanGAP1;

Provider

SWISS-PROT

Sequence

Polypeptide 589 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rangap1	RAN GTPase activating protein 1	56	102	4	69

Sequence references in MGI

J:16895 DeGregori J, et al., A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 1994 Feb 1;8(3):265-76
J:45778 Matunis MJ, et al., SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol. 1998 Feb 9;140(3):499-509
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298016 Cortes-Montero E, et al., The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. Antioxid Redox Signal. 2019 Sep 1;31(7):503-520
J:384035 Dorr A, et al., MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. J Biol Chem. 2015 Oct 16;290(42):25620-35
J:384041 Cha K, et al., The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells. PLoS One. 2015;10(10):e0141309
J:384483 Hutten S, et al., The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol Biol Cell. 2008 May;19(5):2300-10
J:384564 Mahajan R, et al., Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. J Cell Biol. 1998 Jan 26;140(2):259-70
J:384666 Zhu S, et al., SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes. Exp Cell Res. 2006 Apr 15;312(7):1042-9
J:385110 Bernier-Villamor V, et al., Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell. 2002 Feb 8;108(3):345-56