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Ddx3x Gene Detail
Summary
  • Symbol
    Ddx3x
  • Name
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
  • Synonyms
    D1Pas1-rs2, Ddx3, embryonic RNA helicase, Fin14
  • Feature Type
    protein coding gene
  • IDs
    MGI:103064
    NCBI Gene: 13205
  • Gene Overview
    MyGene.info: DDX3X
Location & Maps
more
  • Sequence Map
    ChrX:13280970-13294052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13083 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 8.17 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DDX3X, DEAD-box helicase 3, X-linked
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DDX3X, DEAD-box helicase 3, X-linked
    Orthology source: HomoloGene
  • Synonyms
    CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102
  • Links
    NCBI Gene ID: 1654
    neXtProt AC: NX_O00571

  • Chr Location
    Xp11.3-p11.23; chrX:41333308-41364472 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DDX3X associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 102; MRX102   OMIM: 300958
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    11
  • Targeted
    3
Hemizygous males and heterozygous females with a maternally inherited null allele show early embryonic and fetal lethality, respectively. Both males and females show defects in trophoblast giant cells. Females show defects in placental formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017078 VEGA Gene Model | MGI Sequence Detail 13083 C57BL/6J ±  kb
transcript OTTMUST00000041354 VEGA | MGI Sequence Detail 4692 Not Applicable  
polypeptide OTTMUSP00000018557 VEGA | MGI Sequence Detail 662 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    22 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006364 ATP-dependent RNA helicase DDX3X
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 810
    cDNA 804
    Primer pair 5
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16302, MGD-MRK-23926, MGD-MRK-33748, MGI:106064, MGI:99525
References
more
  • Summaries
    All 46
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:17429 Gee SL, et al., Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gene. 1994 Mar 25;140(2):171-7
  • Latest
    J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 May 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory