About   Help   FAQ
Ddx3x Gene Detail
Summary
  • Symbol
    Ddx3x
  • Name
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
  • Synonyms
    D1Pas1-rs2, Ddx3, embryonic RNA helicase, Fin14
  • Feature Type
    protein coding gene
  • IDs
    MGI:103064
    NCBI Gene: 13205
  • Gene Overview
    MyGene.info: DDX3X
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:13280970-13294052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13083 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 8.17 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DDX3X, DEAD-box helicase 3 X-linked
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DDX3X, DEAD-box helicase 3 X-linked
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102
  • Links
    NCBI Gene ID: 1654
    neXtProt AC: NX_O00571
    UniProt: O00571

  • Chr Location
    Xp11.4; chrX:41333308-41364472 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous males and heterozygous females with a maternally inherited null allele show early embryonic and fetal lethality, respectively. Both males and females show defects in trophoblast giant cells. Females show defects in placental formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017078 VEGA Gene Model | MGI Sequence Detail 13083 C57BL/6J ±  kb
    transcript OTTMUST00000041354 VEGA | MGI Sequence Detail 4692 Not Applicable  
    polypeptide OTTMUSP00000018557 VEGA | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      22 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    Molecular
    Reagents
    less
    • All nucleic 810
      cDNA 804
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16302, MGD-MRK-23926, MGD-MRK-33748, MGI:106064, MGI:99525
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 14
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:17429 Gee SL, et al., Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gene. 1994 Mar 25;140(2):171-7
    • Latest
      J:247276 Neppl RL, et al., lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol. 2017 Nov 06;216(11):3497-3507

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory