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Stat1 Gene Detail
Summary
  • Symbol
    Stat1
  • Name
    signal transducer and activator of transcription 1
  • Synonyms
    2010005J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103063
    NCBI Gene: 20846
  • Gene Overview
    MyGene.info: STAT1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52119440-52161865 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103063
protein coding gene Chr1:52119438-52161865 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016006
protein coding gene Chr1:51628850-51671784 (+)
A/J MGP_AJ_G0015988
protein coding gene Chr1:49900289-49942002 (+)
AKR/J MGP_AKRJ_G0015944
protein coding gene Chr1:50952889-50994736 (+)
BALB/cJ MGP_BALBcJ_G0015945
protein coding gene Chr1:49715568-49757744 (+)
C3H/HeJ MGP_C3HHeJ_G0015777
protein coding gene Chr1:51359021-51402478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016396
protein coding gene Chr1:53800977-53842750 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014128
protein coding gene Chr1:41915041-41956718 (-)
CAST/EiJ MGP_CASTEiJ_G0015358
protein coding gene Chr1:50840041-50881813 (+)
CBA/J MGP_CBAJ_G0015748
protein coding gene Chr1:55235992-55277729 (+)
DBA/2J MGP_DBA2J_G0015849
protein coding gene Chr1:49151562-49193563 (+)
FVB/NJ MGP_FVBNJ_G0015851
protein coding gene Chr1:48616606-48658312 (+)
LP/J MGP_LPJ_G0015920
protein coding gene Chr1:52125262-52166698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015871
protein coding gene Chr1:58262387-58305563 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016444
protein coding gene Chr1:51084199-51125904 (+)
PWK/PhJ MGP_PWKPhJ_G0015144
protein coding gene Chr1:49032952-49074196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014924
protein coding gene Chr1:50737870-50779590 (+)
WSB/EiJ MGP_WSBEiJ_G0015421
protein coding gene Chr1:50889963-50936974 (+)



Homology
more
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Links
    NCBI Gene ID: 6772
    neXtProt AC: NX_P42224
    UniProt: P42224

  • Chr Location
    2q32.2; chr2:190969036-191014250 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Stat1 mouse models; 1 with human STAT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 14 alleles in 22 genetic backgrounds
    26 phenotypes from multigenic genotypes
    366 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026104 Ensembl Gene Model | MGI Sequence Detail 42426 C57BL/6J ±  kb
    transcript ENSMUST00000186057 Ensembl | MGI Sequence Detail 3998 Not Applicable  
    polypeptide ENSMUSP00000141132 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
      IPR038295 STAT1, C-terminal domain superfamily
      IPR035859 STAT1, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 7
      cDNA 25
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23925, MGI:1923977, MGI:2138078
    References
    more
    • Summaries
      All 576
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 19
      Phenotypes 366
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266104 Choi JH, et al., mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory