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Stat1 Gene Detail
Summary
  • Symbol
    Stat1
  • Name
    signal transducer and activator of transcription 1
  • Synonyms
    2010005J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103063
    NCBI Gene: 20846
  • Gene Overview
    MyGene.info: STAT1
Location & Maps
more
  • Sequence Map
    Chr1:52119440-52161865 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42426 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.81 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Links
    NCBI Gene ID: 6772
    neXtProt AC: NX_P42224

  • Chr Location
    2q32.2; chr2:190969036-191014250 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Stat1 mouse models; 3 with human STAT1 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480 View 1 model
       Immunodeficiency 31a; IMD31A   OMIM: 614892
Immunodeficiency 31b; IMD31B   OMIM: 613796
Immunodeficiency 31c; IMD31C   OMIM: 614162
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 11 alleles in 19 genetic backgrounds
    26 phenotypes from multigenic genotypes
    325 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    17
  • Genomic Mutations
    2 involving Stat1
  • Incidental Mutations
Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046734 VEGA Gene Model | MGI Sequence Detail 42426 C57BL/6J ±  kb
transcript OTTMUST00000121564 VEGA | MGI Sequence Detail 3998 Not Applicable  
polypeptide OTTMUSP00000066950 VEGA | MGI Sequence Detail 755 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    396 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000002087 signal transducer and activator of transcription 1
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 33
    Genomic 7
    cDNA 24
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-23925, MGI:1923977, MGI:2138078
References
more
  • Summaries
    All 473
    Developmental Gene Expression 27
    Diseases 1
    Gene Ontology 20
    Phenotypes 325
  • Earliest
    J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
  • Latest
    J:234425 Katzenell S, et al., Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons. J Virol. 2016 May;90(9):4706-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory