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Stat1 Gene Detail
Summary
  • Symbol
    Stat1
  • Name
    signal transducer and activator of transcription 1
  • Synonyms
    2010005J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103063
    NCBI Gene: 20846
  • Gene Overview
    MyGene.info: STAT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:52119440-52161865 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42426 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.81 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT1, signal transducer and activator of transcription 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Links
    NCBI Gene ID: 6772
    neXtProt AC: NX_P42224
    UniProt: P42224

  • Chr Location
    2q32.2; chr2:190969036-191014250 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Stat1 mouse models; 1 with human STAT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 14 alleles in 22 genetic backgrounds
    26 phenotypes from multigenic genotypes
    363 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046734 VEGA Gene Model | MGI Sequence Detail 42426 C57BL/6J ±  kb
    transcript OTTMUST00000121564 VEGA | MGI Sequence Detail 3998 Not Applicable  
    polypeptide OTTMUSP00000066950 VEGA | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      396 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
      IPR038295 STAT1, C-terminal domain superfamily
      IPR035859 STAT1, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 7
      cDNA 25
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23925, MGI:1923977, MGI:2138078
    References
    more
    • Summaries
      All 575
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 19
      Phenotypes 363
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265086 Thome R, et al., Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity. Eur J Immunol. 2018 Jul;48(7):1228-1234

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory