Stat1
Gene Detail

Symbol Name ID

Stat1 signal transducer and activator of transcription 1 MGI:103063

Synonyms

2010005J02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

26.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:52119438-52161865 bp, + strand From NCBI annotation of GRCm38   42428 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat1

Human homologs

Human Homolog		STAT1, signal transducer and activator of transcription 1, 91kDa
NCBI Gene ID		6772
neXtProt AC		NX_P42224
Human Synonyms		CANDF7, ISGF-3, STAT91
Human Chr (Location)		2q32.2; chr2:191833762-191878976 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human STAT1

Alleles and phenotypes

All alleles(18) : Targeted(12) Gene trapped(3) Chemically induced(3)
 

Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.

 

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, blood circulation, ...
Component	axon, cytoplasm, ...
Function	calcium ion binding, CCR5 chemokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (140)    Tissues (105)    Images (25)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	78
Western blot	1
RT-PCR	61

cDNA source data(206)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(220) Genomic(7) cDNA(211) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000026104 (Evidence)
Entrez Gene	20846 (Evidence)
UniGene	277406
DFCI	TC1574482, TC1591999, TC1677045, TC1721010
DoTS	DT.101127301, DT.40153101, DT.483643, DT.55100358, DT.91338196, DT.91580146
NIA Mouse Gene Index	U000263
Consensus CDS Project	CCDS56628.1
International Mouse Knockout Project Status	Stat1

Sequences

Length	Strain/Species
genomic	20846	NCBI Gene Model | MGI Sequence Detail	42428	C57BL/6J
transcript	NM_009283	RefSeq | MGI Sequence Detail	5183	C57BL/6
polypeptide	P42225	UniProt | EBI | MGI Sequence Detail	749	Not Applicable

All sequences(46) RefSeq(6) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(298 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR000980	SH2 domain
InterPro	IPR022752	Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
InterPro	IPR013800	STAT transcription factor, all-alpha
InterPro	IPR015988	STAT transcription factor, coiled coil
InterPro	IPR001217	STAT transcription factor, core
InterPro	IPR013801	STAT transcription factor, DNA-binding
InterPro	IPR012345	STAT transcription factor, DNA-binding, subdomain
InterPro	IPR013799	STAT transcription factor, protein interaction
Protein Ontology	PR:000002087	signal transducer and activator of transcription 1

Graphical View of Protein Domain Structure

References

(Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:195056 Iwasaki Y, et al., Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4(+) T cells. Eur J Immunol. 2013 Apr;43(4):1063-73
All references(392)

Other accession IDs

MGD-MRK-23925, MGI:1923977, MGI:2138078