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Gene Detail
signal transducer and activator of transcription 1
Synonyms 2010005J02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
26.81 cM
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr1:52119440-52161865 bp, + strand
From VEGA annotation of GRCm38

  42426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat1

Human Homolog STAT1, signal transducer and activator of transcription 1, 91kDa
NCBI Gene ID 6772
neXtProt AC  NX_P42224
Human Synonyms  CANDF7, ISGF-3, STAT91
Human Chr (Location)  2q32.2; chr2:190969036-191014250 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human STAT1
alleles, and
All mutations/alleles(16) : Chemically induced (ENU)(4) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.
Stat1 interacts with 323 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (60 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, blood circulation, ...
Component axon, cytoplasm, ...
Function CCR5 chemokine receptor binding, DNA binding, ...
External Resources: FuncBase
Literature Summary: (24 records)
Data Summary: Results (133)    Tissues (107)    Images (25)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 78
Western blot 1
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(33) Genomic(7) cDNA(24) Primer pair(2)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000046734 (Evidence)
Ensembl Gene ModelENSMUSG00000026104 (Evidence)
Entrez Gene20846 (Evidence)
DFCITC1574482, TC1591999, TC1677045, TC1721010
DoTSDT.101127301, DT.40153101, DT.483643, DT.55100358, DT.91338196, DT.91580146
NIA Mouse Gene IndexU000263
Consensus CDS ProjectCCDS56628.1
International Mouse Knockout Project StatusStat1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046734 VEGA Gene Model | MGI Sequence Detail 42426 C57BL/6J ±  kb
transcript OTTMUST00000121564 VEGA | MGI Sequence Detail 3998 Not Applicable 
polypeptide OTTMUSP00000066950 VEGA | MGI Sequence Detail 755 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(12) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(397 from dbSNP Build 137)
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002087 signal transducer and activator of transcription 1
References (Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:211880 Datta S, et al., Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc Biol. 2014 Jun;95(6):853-66
All references(417)
accession IDs
MGD-MRK-23925, MGI:1923977, MGI:2138078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory