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Stat2
Gene Detail
 Symbol
Name
ID
Stat2
signal transducer and activator of transcription 2
MGI:103039
Synonyms 1600010G07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
76.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:128270576-128292849 bp, + strand
From NCBI annotation of GRCm38

  22274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat2

Human
homologs
Human Homolog STAT2, signal transducer and activator of transcription 2, 113kDa
NCBI Gene ID 6773
neXtProt AC  NX_P52630
Human Synonyms  ISGF-3, P113, STAT113
Human Chr (Location)  12q13.3; chr12:56341597-56360271 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Immune response is impaired in homozygous null mice.
 
Interactions
Stat2 interacts with 182 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process regulation of transcription, DNA-templated, signal transduction, ...
Component cytoplasm, nucleus, ...
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (77)    Tissues (56)    Images (7)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 23, 28
Assay TypeResults
RNA in situ 69
RT-PCR 8
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000040033 (Evidence)
Entrez Gene20847 (Evidence)
DFCITC1576612, TC1593141
DoTSDT.101153406, DT.491234
NIA Mouse Gene IndexU012176
Consensus CDS ProjectCCDS24269.1
International Mouse Knockout Project StatusStat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20847 NCBI Gene Model | MGI Sequence Detail 22274 C57BL/6J ±  kb
transcript NM_019963 RefSeq | MGI Sequence Detail 4402 B10.A-H2 
polypeptide Q9WVL2 UniProt | EBI | MGI Sequence Detail 923 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(10) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR022756 Signal transducer and activation of transcription 2, C-terminal
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002088 signal transducer and activator of transcription 2
Graphical View of Protein Domain Structure
References (Earliest) J:28833 Copeland NG, et al., Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 1995 Sep 1;29(1):225-8
(Latest) J:204181 Stewart CA, et al., Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest. 2013 Oct 8;
All references(74)
Other
accession IDs
MGD-MRK-23901, MGI:1919271, MGI:2143845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory