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Stat2
Gene Detail
Symbol

Name
ID
Stat2
signal transducer and activator of transcription 2
MGI:103039
Synonyms
1600010G07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:128270576-128292849 bp, + strand
From Ensembl annotation of GRCm38

  22274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: STAT2
Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat2

Human
homologs
STAT2, signal transducer and activator of transcription 2, 113kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6773
neXtProt AC: NX_P52630

Human Synonyms: ISGF-3, P113, STAT113

Human Chr (Location): 12q13.3; chr12:56341597-56360253 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Immune response is impaired in homozygous null mice.
 
Interactions
Stat2 interacts with 182 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (77)    Tissues (56)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
RT-PCR 8
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stat2    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000040033 (Evidence)
Entrez Gene 20847 (Evidence)
DFCI TC1593141, TC1576612
DoTS DT.491234, DT.101153406
NIA Mouse Gene Index U012176
Consensus CDS Project CCDS24269.1
International Mouse Phenotyping Consortium Status Stat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040033 Ensembl Gene Model | MGI Sequence Detail 22274 C57BL/6J ±  kb
transcript ENSMUST00000105238 Ensembl | MGI Sequence Detail 4397 Not Applicable 
polypeptide ENSMUSP00000100872 Ensembl | MGI Sequence Detail 923 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR022756 Signal transducer and activation of transcription 2, C-terminal
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002088 signal transducer and activator of transcription 2
References
(Earliest) J:28833 Copeland NG, et al., Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 1995 Sep 1;29(1):225-8
(Latest) J:220134 Sheikh F, et al., An essential role for IFN-beta in the induction of IFN-stimulated gene expression by LPS in macrophages. J Leukoc Biol. 2014 Oct;96(4):591-600
All references(75)
Other
accession IDs
MGD-MRK-23901, MGI:1919271, MGI:2143845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory