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Stat2 Gene Detail
Summary
  • Symbol
    Stat2
  • Name
    signal transducer and activator of transcription 2
  • Synonyms
    1600010G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103039
    NCBI Gene: 20847
Location & Maps
more
  • Sequence Map
    Chr10:128270576-128292849 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22274 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STAT2, signal transducer and activator of transcription 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STAT2, signal transducer and activator of transcription 2
    Orthology source: HomoloGene
  • Synonyms
    ISGF-3, P113, STAT113
  • Links
    NCBI Gene ID: 6773
    neXtProt AC: NX_P52630

  • Chr Location
    12q13.3; chr12:56341597-56360253 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    6
  • Targeted
    2
  • Incidental Mutations
Immune response is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040033 Ensembl Gene Model | MGI Sequence Detail 22274 C57BL/6J ±  kb
transcript ENSMUST00000105238 Ensembl | MGI Sequence Detail 4397 Not Applicable  
polypeptide ENSMUSP00000100872 Ensembl | MGI Sequence Detail 923 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000002088 signal transducer and activator of transcription 2
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR022756 Signal transducer and activation of transcription 2, C-terminal
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-23901, MGI:1919271, MGI:2143845
References
more
  • Summaries
    All 73
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:28833 Copeland NG, et al., Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 1995 Sep 1;29(1):225-8
  • Latest
    J:224099 Rauch I, et al., Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons. Mol Cell Biol. 2015 Jul;35(13):2332-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory