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Stat5a Gene Detail
Summary
  • Symbol
    Stat5a
  • Name
    signal transducer and activator of transcription 5A
  • Synonyms
    STAT5
  • Feature Type
    protein coding gene
  • IDs
    MGI:103036
    NCBI Gene: 20850
Location & Maps
more
  • Sequence Map
    Chr11:100859351-100885169 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25819 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STAT5A, signal transducer and activator of transcription 5A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    STAT5A, signal transducer and activator of transcription 5A
    Orthology source: HomoloGene
  • Synonyms
    MGF, STAT5
  • Links
    NCBI Gene ID: 6776
    neXtProt AC: NX_P42229

  • Chr Location
    17q11.2; chr17:42287547-42311943 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 6 genetic backgrounds
    84 phenotypes from multigenic genotypes
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    2 involving Stat5a
  • Incidental Mutations
Mice homozygous for disruptions in this gene are reduced in size and display abnormalities in both mammary gland structure and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002125 VEGA Gene Model | MGI Sequence Detail 25819 C57BL/6J ±  kb
transcript OTTMUST00000004311 VEGA | MGI Sequence Detail 3738 Not Applicable  
polypeptide OTTMUSP00000002046 VEGA | MGI Sequence Detail 793 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000002091 signal transducer and activator of transcription 5a
  • PDB
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 73
    cDNA 69
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23874, MGI:2144052
References
more
  • Summaries
    All 260
    Developmental Gene Expression 21
    Gene Ontology 31
    Phenotypes 139
  • Earliest
    J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
  • Latest
    J:228007 Haetscher N, et al., STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nat Commun. 2015;6:8928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory