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Stat5a
Gene Detail
Symbol

Name
ID
Stat5a
signal transducer and activator of transcription 5A
MGI:103036
Synonyms
STAT5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:100859351-100885169 bp, + strand
From VEGA annotation of GRCm38

  25819 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat5a

Human
homologs
Human Homolog STAT5A, signal transducer and activator of transcription 5A
NCBI Gene ID 6776
neXtProt AC  NX_P42229
Human Synonyms  MGF, STAT5
Human Chr (Location)  17q11.2; chr17:42287547-42311943 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Stat5a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are reduced in size and display abnormalities in both mammary gland structure and function.
 
Interactions
Stat5a interacts with 158 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process 2-oxoglutarate metabolic process, allantoin metabolic process, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (371)    Tissues (229)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 281
RT-PCR 90
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(69) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002125 (Evidence)
Ensembl Gene ModelENSMUSG00000004043 (Evidence)
Entrez Gene20850 (Evidence)
UniGene277403
DFCITC1670148, TC1578341
NIA Mouse Gene IndexU013347
PDB1Y1U
Consensus CDS ProjectCCDS25439.1, CCDS48933.1
International Mouse Knockout Project StatusStat5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002125 VEGA Gene Model | MGI Sequence Detail 25819 C57BL/6J ±  kb
transcript OTTMUST00000004310 VEGA | MGI Sequence Detail 3888 Not Applicable 
polypeptide OTTMUSP00000002045 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)    SNPs within 2kb including multiple locations(127)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002091 signal transducer and activator of transcription 5a
References
(Earliest) J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
(Latest) J:214130 Robinson GW, et al., Coregulation of genetic programs by the transcription factors NFIB and STAT5. Mol Endocrinol. 2014 May;28(5):758-67
All references(257)
Other
accession IDs
MGD-MRK-23874, MGI:2144052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory